sh2d1b
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  • Official Full Name
  • SH2 domain containing 1B
  • Background
  • By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal;transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 (PubMed;11689425)).
  • Synonyms
  • SH2D1B; SH2 domain containing 1B; SH2 domain-containing protein 1B; EAT2; EAT 2; EWS/FLI1 activated transcript 2; SH2 domain containing molecule EAT2; SH2 domain containing protein 1B; EAT-2; EWS/FLI1-activated transcript 2; SH2 domain-containing molecule EAT2
Cat.#:SH2D1B-1337HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SH2D1B Protein, MYC/DDK-tagged
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Cat.#:SH2D1B-210HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human SH2D1B Protein, His-tagged
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Cat.#:SH2D1B-2640HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SH2D1B, GST-tagged
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Cat.#:SH2D1B-5343CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SH2D1B
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Cat.#:SH2D1B-1597HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SH2D1B cell lysate
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Involved Pathway

SH2D1B involved in several pathways and played different roles in them. We selected most pathways SH2D1B participated on our site, such as Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2D1B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
CSK; MAP3K8; KIF2C; DNM1; KLRG1; TRAT1; NA; KIF22; RNF25; UBE2V2
Immune System
PPIAL4A; KIF26A; CTSC; CD200R2; SIGLEC10; ARIH1; DEFB106A; DEFB129; CSHL1; KLRB1B
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
CD300LF; Mill2; KLRB1F; CD226; SIGLEC9; CRTAM; CD200R4; CD200; SIGLEC6; LILRB3
Natural killer cell mediated cytotoxicity
CD244; VAV2; LCK; ZAP70; IFNA10; ULBP2; NCR3; TNFRSF10B; HLA-G; KIR2DL3

Protein Function

SH2D1B has several biochemical functions, for example, protein binding, protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2D1B itself. We selected most functions SH2D1B had, and list some proteins which have the same functions with SH2D1B. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein PNRC2; CCDC85B; LGALS9C; ACTR8; SFTPC; NHEJ1; ADCK3; TAE1; PAWR; HSPB8
Function protein binding, bridging
Related Protein NMD3; GOLGA5; NUFIP1; TRIM5; ADAP2; TCAP; NEFL; PPP4R2; LOR; CBX5

Interacting Protein

SH2D1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2D1B here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2D1B.
q53hf2_human; TRIM54; CD84; OLIG1; STAT4; ERBB2; MET

SH2D1B Related Articles

Kurzer, JH; Argetsinger, LS; et al. Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. MOLECULAR AND CELLULAR BIOLOGY 24:4557-4570(2004).