siah2
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  • Official Full Name
  • siah E3 ubiquitin protein ligase 2
  • Background
  • This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]
  • Synonyms
  • SIAH2; siah E3 ubiquitin protein ligase 2; hSiah2; E3 ubiquitin-protein ligase SIAH2; siah-2; seven in absentia homolog 2;
Cat.#:SIAH2-15122MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SIAH2 Protein
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Cat.#:SIAH2-5397RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SIAH2 Protein
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Cat.#:SIAH2-4201RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SIAH2 Protein, His-tagged
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Cat.#:SIAH2-1850HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SIAH2 293 Cell Lysate
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Involved Pathway

SIAH2 involved in several pathways and played different roles in them. We selected most pathways SIAH2 participated on our site, such as Axon guidance, Developmental Biology, Netrin-1 signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIAH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
SPRED1; GNAI3; RHOC; GPC1A; FGF10B; SCN3B; NTNG1; PLXND1; SEMA7A; EFNB3
Developmental Biology
PEBP1; SPTB; MED7; ANK2B; DOCK1; ACTR3; DPYSL3; CDK19; EFNA1A; DPYSL2B
Netrin-1 signaling
TRPC4; HFE2; NTN1A; EZRA; NTN1B; UNC5D; TRPC5; PITPNA; RNF8; RGMA
Parkin-Ubiquitin Proteasomal System pathway
RNF19A; HSPA14; TUBA3E; SIAH2; HSPA7; UBE2J2; STUB1; TUBA1B; TUBB7P; TUBA3D

Protein Function

SIAH2 has several biochemical functions, for example, ligase activity, protein binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIAH2 itself. We selected most functions SIAH2 had, and list some proteins which have the same functions with SIAH2. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein RNF14; TRIM69; SMURF1; UBR4; BRCA1; MKRN1; TRIM5; TRIM41; TTLL9; ADSSL
Function protein binding
Related Protein GAS7; USE1; TRPV6; EMP3; CXCR4; PTPMT1; SIX1; PDCD2; HOMER2; XCL2
Function transcription corepressor activity
Related Protein PPP1R13L; LDB1; DR1; KCTD1; MAP3K10; ATF7IP; KCNA3; SRSF2; SSX1; ARHGAP35
Function ubiquitin conjugating enzyme binding
Related Protein DCUN1D1; DCUN1D5; RNF19A; RNF14; TCHP; RNF144AB; ANKIB1; RNF217; ARIH1; GRIK2
Function ubiquitin protein ligase activity
Related Protein FBXL22; UBE2Z; RNF165; TRIM2; UBE2B; ARIH1; SIAH2; UBE2T; RNF222; UBE2C
Function zinc ion binding
Related Protein SEC24D; RNF149; TRIM71; PIAS1; ZBBX; CBLL1; NR5A1; ZNRF2A; NR1D4A; MT1X

Interacting Protein

SIAH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIAH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIAH2.
OPRM1; SH3RF1; MYD88; Oprd1; OPRK1; EEF1D; STAT3; ATN1; UBE2I; Pou2af1; CCBE1; SETD2; HIPK3; CACYBP; ppap_human_gene; fxyd3_human_gene

SIAH2 Related Articles

Tan, JTM; Prosser, HCG; et al. High- density lipoproteins augment hypoxia-induced angiogenesis via regulation of post- translational modulation of hypoxia- inducible factor 1 alpha. FASEB JOURNAL 28:206-217(2014).
MacLeod, RJ; Hayes, M; et al. Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 293:G403-G411(2007).