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SIGLEC1

  • Official Full Name

    sialic acid binding Ig-like lectin 1, sialoadhesin

  • Overview

    This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule;that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane;protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions.;Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound;;however, the full-length nature of this variant has not been determined.
  • Synonyms

    SIGLEC1; sialic acid binding Ig-like lectin 1, sialoadhesin; sialoadhesin , SN; sialoadhesin; CD169; dJ1009E24.1; FLJ00051; FLJ00055; FLJ00073; FLJ32150; SIGLEC 1; sialic acid-binding Ig-like lectin 1; sialic acid-binding immunoglobulin-like lectin 1; SN; SIGLEC-1; FLJ00411; DKFZp667F058;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Pig
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian cells
  • C
  • His
  • Fc Chimera
  • Flag
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SIGLEC1-5677H Recombinant Human SIGLEC1 protein, His-tagged E.coli His Pro1272~Leu1411 (Accession # Q9BZZ2)
Human SIGLEC1-569H Recombinant Human SIGLEC1 protein, His-tagged HEK293 His Ser 20 - Gln 1641
Human SIGLEC1-838H Recombinant Human SIGLEC1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SIGLEC1-133H Recombinant Human SIGLEC1 Protein, C-His-tagged E.coli C-His
Human SIGLEC1-1578HFL Recombinant Full Length Human SIGLEC1 Protein, C-Flag-tagged Mammalian cells Flag
Human SIGLEC1-2009H-B Recombinant Human SIGLEC1 Protein Pre-coupled Magnetic Beads HEK293
Human SIGLEC1-2009H Recombinant Human SIGLEC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SIGLEC1-5116H Recombinant Human SIGLEC1 Protein (Ser20-Gln1641), C-His tagged Mammalian cells C-His Ser20-Gln1641
Human SIGLEC1-1413H Recombinant Human SIGLEC1 Protein (Gly34-Gly240), N-His tagged E.coli N-His Gly34-Gly240
Mouse Siglec1-523M Active Recombinant Mouse Siglec1, Fc Chimera Mammalian cells Fc Chimera
Mouse Siglec1-146M-B Recombinant Mouse Siglec1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Siglec1-5876M Recombinant Mouse Siglec1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Siglec1-146M Recombinant Mouse Siglec1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig SIGLEC1-1341P Recombinant Pig SIGLEC1 protein, His&Myc-tagged E.coli His&Myc 20-153aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SIGLEC1 Related Research Area

SIGLEC1 involved in several pathways and played different roles in them. We selected most pathways SIGLEC1 participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with SIGLEC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)VCAN;ITGB2L;CNTN2;CDH3;CD6;CLDNK;BF1;L1CAM;HLA-B

SIGLEC1 has several biochemical functions, for example, carbohydrate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIGLEC1 itself. We selected most functions SIGLEC1 had, and list some proteins which have the same functions with SIGLEC1. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingPKD1L2;NOMO3;MRC2;MAG;KLRC1;PYGM;GALNTL1;LGALSLA;Reg2
protein bindingDEAF1;PEPD;ZDHHC13;OIT3;SATB1;RAB33A;KANK2;NGDN;NUMA1

SIGLEC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIGLEC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIGLEC1.

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