Recombinant Full Length Human SIGLEC1 Protein, C-Flag-tagged

• Cat.No.: SIGLEC1-1578HFL
• Product Overview: Recombinant Full Length Human SIGLEC1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 180.6 kDa
• AA Sequence: MGFLPKLLLLASFFPAGQASWGVSS PQDVQGVKGSCLLIPCIFSFPADVE VPDGITAIWYYDYSGQRQV VSHSADPKLVEARFRGRTEFMGNPE HRVCNLLLKDLQPEDSGSYNFRFEI SEVNRWSDVKGTLVTVTEE PRVPTIASPVELLEGTEVDFNCSTP YVCLQEQVRLQWQGQDPARSVTFNS QKFEPTGVGHLETLHMAMS WQDHGRILRCQLSMANHRAQSEIHL QVKYAPRGVKILLSPSGRNILPGEL VTLTCQVNSSYPAVSSIKW LKDGVRLQTKTGVLHLPQAAWSDAG VYTCQAENGVGSLVSPPISLHIFMA EVQVSPAGPILENQTVTLV CNTPNEAPSDLRYSWYKNHVLLEDA HSHTLRLHLATRADTGFYFCEVQNV HGSERSGPVSVVVNHPPLT PVLTAFLETQAGLVGILHCSVVSEP LATLVLSHGGHILASTSGDSDHSPR FSGTSGPNSLRLEIRDLEE TDSGEYKCSATNSLGNATSTLDFHA NAARLLISPAAEVVEGQAVTLSCRS GLSPTPDARFSWYLNGALL HEGPGSSLLLPAASSTDAGSYHCRA RDGHSASGPSSPAVLTVLYPPRQPT FTTRLDLDAAGAGAGRRGL LLCRVDSDPPARLQLLHKDRVVATS LPSGGGCSTCGGCSPRMKVTKAPNL LRVEIHNPLLEEEGLYLCE ASNALGNASTSATFNGQATVLAIAP SHTLQEGTEANLTCNVSREAAGSPA NFSWFRNGVLWAQGPLETV TLLPVARTDAALYACRILTEAGAQL STPVLLSVLYPPDRPKLSALLDMGQ GHMALFICTVDSRPLALLA LFHGEHLLATSLGPQVPSHGRFQAK AEANSLKLEVRELGLGDSGSYRCEA TNVLGSSNTSLFFQVRGAW VQVSPSPELQEGQAVVLSCQVPTGV PEGTSYRWYRDGQPLQESTSATLRF AAITLTQAGAYHCQAQAPG SATTSLAVPISLHVSYAPRHVTLTT LMDTGPGRLGLLLCRVDSDPPAQLR LLHGDRLVASTLQGVGGPE GSSPRLHVAVAPNTLRLEIHGAMLE DEGVYICEASNTLGQASASADFDAQ AVNVQVWPGATVREGQLVN LTCLVWTTHPAQLTYTWYQDGQQRL DAHSIPLPNVTVRDATSYRCGVGPP GRAPRLSRPITLDVLYAPR NLRLTYLLESHGGQLALVLCTVDSR PPAQLALSHAGRLLASSTAASVPNT LRLELRGPQPRDEGFYSCS ARSPLGQANTSLELRLEGVRVILAP EAAVPEGAPITVTCADPAAHAPTLY TWYHNGRWLQEGPAASLSF LVATRAHAGAYSCQAQDAQGTRSSR PAALQVLYAPQDAVLSSFRDSRARS MAVIQCTVDSEPPAELALS HDGKVLATSSGVHSLASGTGHVQVA RNALRLQVQDVPAGDDTYVCTAQNL LGSISTIGRLQVEGARVVA EPGLDVPEGAALNLSCRLLGGPGPV GNSTFAWFWNDRRLHAEPVPTLAFT HVARAQAGMYHCLAELPTG AAASAPVMLRVLYPPKTPTMMVFVE PEGGLRGILDCRVDSEPLASLTLHL GSRLVASSQPQGAPAEPHI HVLASPNALRVDIEALRPSDQGEYI CSASNVLGSASTSTYFGVRALHRLH QFQQLLWVLGLLVGLLLLL
  LGLGACYTWRRRRVCKQSMGENSVE MAFQKETTQLIDPDAATCETSTCAP PLGLEQKLISEEDLAANDILDYKDD DDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)

Gene Information

• Gene Name: SIGLEC1 sialic acid binding Ig like lectin 1 [ Homo sapiens (human) ]
• Official Symbol: SIGLEC1
• Synonyms: SN; CD169; SIGLEC-1
• Gene ID: 6614
• mRNA Refseq: NM_023068.4
• Protein Refseq: NP_075556.1
• MIM: 600751
• UniProt ID: Q9BZZ2