Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

SIGLEC12

Official Full Name

sialic acid binding Ig-like lectin 12 (gene/pseudogene)
Overview

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
Synonyms

SIGLEC12; sialic acid binding Ig-like lectin 12 (gene/pseudogene); sialic acid binding Ig like lectin 12 , SIGLEC like 1 , SIGLECL1; sialic acid-binding Ig-like lectin 12; S2V; Siglec 12; Siglec L1; Siglec XII; SLG; SIGLEC-like 1; sialic acid-binding Ig-;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human

Source

E.coli
HEK293
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SIGLEC12-6712H	Recombinant Human SIGLEC12 protein, His-tagged	E.coli	His	Lys22~Gly218 (Accession # Q96PQ1)	Inquiry
Human	SIGLEC12-6713H	Recombinant Human SIGLEC12 protein, His-tagged	E.coli	His	Leu317~Pro512 (Accession # Q96PQ1)	Inquiry
Human	SIGLEC12-1605HCL	Recombinant Human SIGLEC12 cell lysate		N/A		Inquiry
Human	SIGLEC12-444HFL	Recombinant Full Length Human SIGLEC12 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	SIGLEC12-2010H-B	Recombinant Human SIGLEC12 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	SIGLEC12-2010H	Recombinant Human SIGLEC12 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	SIGLEC12-6680H	Recombinant Human SIGLEC12 Protein (Lys22-Gly218), His tagged	E.coli	His	Lys22-Gly218	Inquiry

Involved Pathway
Protein Function
Interacting Protein

SIGLEC12 involved in several pathways and played different roles in them. We selected most pathways SIGLEC12 participated on our site, such as Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIGLEC12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	CD300LD;ASB11;ITGB1B.1;SPSB4;SIGLEC11;CD300E;GM11711;ERAP2;RASGRP2
Immune System	CASP2;CD96;CTSC;KIF18A;TRIM56;KIFAP3;UNC93B1;RNF41;POLR3G
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	LILRB1;CD300A;KLRB1B;KLRB1A;LILRB5;Siglece;SH2D1B;CD300LF;LILRA3

SIGLEC12 has several biochemical functions, for example, carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIGLEC12 itself. We selected most functions SIGLEC12 had, and list some proteins which have the same functions with SIGLEC12. You can find most of the proteins on our site.

Function	Related Protein
carbohydrate binding	CD34;MGAT2;MAN2A2;Cd24a;LPHN1;Clec4n;FCNA;GALNT7;FBXO2

SIGLEC12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIGLEC12 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIGLEC12.