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SIRT7

  • Official Full Name

    sirtuin 7

  • Overview

    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
  • Synonyms

    SIRT7; sirtuin 7; sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7; NAD-dependent deacetylase sirtuin-7; sirtuin type 7; SIR2-like protein 7;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SIRT7-12H Recombinant Human SIRT7, Flag-tagged E.coli Flag
Human SIRT7-30867TH Recombinant Human SIRT7, His-tagged Sf9 Insect Cell His 400 amino acids
Human SIRT7-30848TH Recombinant Human SIRT7, T7 -tagged E.coli T7
Human SIRT7-585H Recombinant Human SIRT7, His-tagged E.coli His
Human SIRT7-4884H Recombinant Human Sirtuin 7, His-tagged Sf9 Insect Cell His
Human SIRT7-1828HCL Recombinant Human SIRT7 293 Cell Lysate HEK293 N/A
Human SIRT7-120H Recombinant Human SIRT7 Protein, His-tagged E. coli His 2-400
Human SIRT7-21H Recombinant Human SIRT7 Protein, His-tagged E.coli His 2-400
Human SIRT7-641HFL Active Recombinant Full Length Human SIRT7 Protein, C-Flag-tagged Mammalian cells Flag
Human SIRT7-2016H-B Recombinant Human SIRT7 Protein Pre-coupled Magnetic Beads HEK293
Human SIRT7-3230H Recombinant Human SIRT7 protein, His-tagged E.coli His 199-400 aa
Human SIRT7-2016H Recombinant Human SIRT7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SIRT7-5904H Recombinant Human SIRT7 Protein (Met1-Thr400), N-His tagged E.coli N-His Met1-Thr400
Mouse SIRT7-15157M Recombinant Mouse SIRT7 Protein Mammalian Cell His
Mouse SIRT7-8184M-B Recombinant Mouse SIRT7 Protein Pre-coupled Magnetic Beads HEK293
Mouse Sirt7-5886M Recombinant Mouse Sirt7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SIRT7-8184M Recombinant Mouse SIRT7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Sirt7-1383R Recombinant Rat Sirt7 protein, His-tagged E.coli His Pro135~Val274 (Accession # B2RZ55)
Rat SIRT7-5410R Recombinant Rat SIRT7 Protein Mammalian Cell His
Rat SIRT7-5069R Recombinant Rat SIRT7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SIRT7-5069R-B Recombinant Rat SIRT7 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SIRT7-4207R Recombinant Rhesus monkey SIRT7 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SIRT7-4023R Recombinant Rhesus Macaque SIRT7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SIRT7-4023R-B Recombinant Rhesus Macaque SIRT7 Protein Pre-coupled Magnetic Beads HEK293
Chicken SIRT7-5512C Recombinant Chicken SIRT7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SIRT7 Related Articles
  • SIRT7 Related Research Area

SIRT7 involved in several pathways and played different roles in them. We selected most pathways SIRT7 participated on our site, such as Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class III, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling events mediated by HDAC Class ISIRT2;WDR77;PRMT5;NR2C1;FKBP3;SIRT5;GATA2;MXD1;SIRT7
Signaling events mediated by HDAC Class IIISIRT7;SIRT2

SIRT7 has several biochemical functions, for example, NAD+ binding, NAD-dependent histone deacetylase activity (H3-K18 specific), chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT7 itself. We selected most functions SIRT7 had, and list some proteins which have the same functions with SIRT7. You can find most of the proteins on our site.

Function Related Protein
NAD+ bindingSIRT1;SIRT3;HPGD;SIRT7;SIRT6;SIRT4;GLUD1;UXS1;SIRT2
NAD-dependent histone deacetylase activity (H3-K18 specific)
chromatin bindingDNMT1;HMGB2;POLA1;LEF1;PRIMPOL;FANCM;CSNK2B;TRPS1;RBPJL
metal ion bindingGNA13;NAIP1;NR1H5;ZFP641;CLCNKB;NCS1A;CYP2D26;HBAE1;NUDT12
protein bindingAPEX1;CAMK1;GCC2;SKP1;HIST1H2AG;CEBPG;SNRNP40;DZIP1;OLFM1

SIRT7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT7.

MAGED1; CBX1

Kiran, S; Chatterjee, N; et al. Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal. FEBS JOURNAL 280:3451-3466(2013).
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