SLAMF1 Protein, signaling lymphocytic activation molecule family member 1


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Official Full Name signaling lymphocytic activation molecule family member 1
Background CD150, designated SLAM (Signaling Lymphocyte Activation Molecule) or CDw150, belongs to the immunoglobulin gene superfamily and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form, the soluble form and the cytoplasmic isoforms of SLAM. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells.
Synonyms SLAMF1; signaling lymphocytic activation molecule family member 1; signaling lymphocytic activation molecule; signaling lymphocyte activation molecule; Slam; CD150; IPO-3; CDw150; ESTM51; AA177906; 4933415F16; MGC151472; MGC151476
    • Species :
    • Human
    • Rat
    • Rhesus monkey
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Tag :
    • Fc
    • hIgG1
    • hIgG4
    • His
    • Avi
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SLAMF1-351H Recombinant Human SLAMF1 protein, His-tagged HEK293 His
    Human SLAMF1-680H Recombinant Human SLAMF1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human SLAMF1-2760HCL Recombinant Human SLAMF1 cell lysate Human Cell N/A
    Human SLAMF1-3187H Recombinant Human SLAMF1, His tagged Human Cell His
    Human SLAMF1-678H Recombinant Human SLAMF1, Fc-tagged, Biotinylated Human Cell Fc
    Human SLAMF1-679H Recombinant Human SLAMF1, Fc-tagged Human Cell Fc
    Human SLAMF1-7101H Recombinant Human SLAMF1, His-tagged E.coli His
    Rat SLAMF1-1004RCL Recombinant Rat SLAMF1 cell lysate Human Cell N/A
    Rat Slamf1-1103R Recombinant Rat Slamf1 Protein, Fc-tagged HEK293 Fc
    Rat Slamf1-37R Recombinant Rat Slamf1, His tagged Human Cell His
    Rat Slamf1-7102R Recombinant Rat Slamf1 protein, His & T7-tagged E.coli His/T7
    Rhesus monkey SLAMF1-1582R Recombinant Rhesus Monkey SLAMF1 Protein HEK293 N/A
    Rhesus monkey SLAMF1-1583R Recombinant Rhesus Monkey SLAMF1 Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey SLAMF1-1584R Recombinant Rhesus Monkey SLAMF1 Protein, hIgG4-tagged HEK293 hIgG4

    SLAMF1 involved in several pathways and played different roles in them. We selected most pathways SLAMF1 participated on our site, such as Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLAMF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Measles PIK3CB; OAS2; IFNA10; TLR4; IL2RA; IL6; IFNAR1; CD209B; MAVS; TLR7

    SLAMF1 has several biochemical functions, for example, antigen binding, protein binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLAMF1 itself. We selected most functions SLAMF1 had, and list some proteins which have the same functions with SLAMF1. You can find most of the proteins on our site.

    Function Related Protein
    antigen binding LILRA1; LILRA3; LAG3; HNRNPM; Ighg; Ighg2a; CD40; LILRA2; PPP2R1A; IL7R
    protein binding MAPKAP1; GLB1; SCO2; CXXC11; ATCAY; STX6; PDCD6; EXOSC5; TAF1A; TPT1
    transmembrane signaling receptor activity HIST2H3C2; TLR9; SLAMF1; TNFRSF10C; FZD3A; GHRHRA; Cd79a, Cd79b; TLR2-2; GABRQ; KLRC1
    virus receptor activity SIVA1; EFNB2; CLEC4M; GYPA; LDLR; CD80; EFNB3; DAG1; SLC10A1; HLA-DRB1

    SLAMF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLAMF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLAMF1.

    SH2D1A; H; PTPN11; INPP5D

    van Driel, B; Liao, GX; et al. Signaling Lymphocyte Activation Molecule Regulates Development of Colitis in Mice. GASTROENTEROLOGY 143:1544-+(2012).
    Calderon, J; Maganto-Garcia, E; et al. The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi. PLOS PATHOGENS 8:-(2012).

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