• Official Full Name
  • solute carrier family 29 (nucleoside transporters), member 4
  • Background
  • This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized.
  • Synonyms
  • SLC29A4; solute carrier family 29 (nucleoside transporters), member 4; equilibrative nucleoside transporter 4; ENT4; FLJ34923; Brain transport protein PMAT; ENT 4; Plasma membrane monoamine transporter; PMAT; Solute carrier family 29 (nucleoside transporters) member 4; Solute carrier family 29 member 4; hENT4; OTTHUMP00000025415; OTTHUMP00000200583; OTTHUMP00000200584
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SLC29A4 Protein
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SLC29A4
Source (Host):HEK293Species:Human
Product nameRecombinant Human SLC29A4 lysate

Involved Pathway

SLC29A4 involved in several pathways and played different roles in them. We selected most pathways SLC29A4 participated on our site, such as SLC-mediated transmembrane transport, Transmembrane transport of small molecules, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC29A4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
SLC-mediated transmembrane transport
SLC5A6B; SLC1A3A; SLC38A4; SLC22A7A; SLC10A6; SLC2A12; SLC2A13; RHBG; SLC12A3; SLC39A1
Transmembrane transport of small molecules
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
SLC29A3; SLC29A4; SLC28A1; SLC29A2; SLC28A2; SLC29A1A; SLC28A3
Transport of vitamins, nucleosides, and related molecules
LCN9; SLC35A2; SLC28A2; SLC28A3; SLC29A1A; SLC35A3; LCN1; SLC29A2; SLC5A6A; SLCO2A1

Protein Function

SLC29A4 has several biochemical functions, for example, monoamine transmembrane transporter activity, nucleoside transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC29A4 itself. We selected most functions SLC29A4 had, and list some proteins which have the same functions with SLC29A4. You can find most of the proteins on our site.
Related Protein
Function monoamine transmembrane transporter activity
Related Protein SLC6A4; SLC18A1; SLC6A2; SLC22A1; SLC18A2; SLC6A3; SLC29A4
Function nucleoside transmembrane transporter activity
Related Protein SLC29A2; SLC29A3; SLC29A4; SLC29A1; SLC28A1; SLC29A1A

SLC29A4 Related Articles

Adamsen, D; Ramaekers, V; et al. Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene. MOLECULAR AUTISM 5:-(2014).
Duan, HC; Wang, JN; et al. Impaired monoamine and organic cation uptake in choroid plexus in mice with targeted disruption of the plasma membrane monoamine transporter (Slc29a4)gene. FASEB JOURNAL 27:-(2013).