Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

SLC29A4

Official Full Name

solute carrier family 29 (nucleoside transporters), member 4
Overview

This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized.
Synonyms

SLC29A4; solute carrier family 29 (nucleoside transporters), member 4; equilibrative nucleoside transporter 4; ENT4; FLJ34923; Brain transport protein PMAT; ENT 4; Plasma membrane monoamine transporter; PMAT; Solute carrier family 29 (nucleoside transporters) member 4; Solute carrier family 29 member 4; hENT4; OTTHUMP00000025415; OTTHUMP00000200583; OTTHUMP00000200584;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SLC29A4-602HCL	Recombinant Human SLC29A4 lysate	HEK293	N/A		Inquiry
Human	SLC29A4-3944H	Recombinant Human SLC29A4 protein, His-tagged	E.coli	His	239-337 aa	$319 / 25ug
Mouse	SLC29A4-15358M	Recombinant Mouse SLC29A4 Protein	Mammalian Cell	His		Inquiry
Mouse	SLC29A4-8309M-B	Recombinant Mouse SLC29A4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	SLC29A4-8309M	Recombinant Mouse SLC29A4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	SLC29A4-5070Z	Recombinant Zebrafish SLC29A4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SLC29A4 Related Articles

SLC29A4 involved in several pathways and played different roles in them. We selected most pathways SLC29A4 participated on our site, such as SLC-mediated transmembrane transport, Transmembrane transport of small molecules, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC29A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
SLC-mediated transmembrane transport	SLC39A7;SLC2A6;SLC6A6;SLC6A18;SLC13A2;SLC2A15B;SLC13A5;SLC22A7A;SLC22A12
Transmembrane transport of small molecules	ATP2C1;SLC5A11;SLC9A3.1;LCN9;CLCN4-2;SLC7A6;SLC43A2;SLC43A2A;GLRBA
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	SLC29A2;SLC28A1;SLC28A3;SLC29A1A;SLC29A3;SLC29A4;SLC28A2
Transport of vitamins, nucleosides, and related molecules	LCN9;SLC5A6A;SLC29A2;APOD;SLC28A3;LCN15;SLC29A3;SLC5A6B;SLC35B4

SLC29A4 has several biochemical functions, for example, monoamine transmembrane transporter activity, nucleoside transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC29A4 itself. We selected most functions SLC29A4 had, and list some proteins which have the same functions with SLC29A4. You can find most of the proteins on our site.

Function	Related Protein
monoamine transmembrane transporter activity	SLC6A2;SLC22A1;SLC6A3;SLC29A4;SLC18A2;SLC6A4;SLC18A1
nucleoside transmembrane transporter activity	SLC29A2;SLC29A1A;SLC29A1;SLC29A3;SLC28A1;SLC29A4

SLC29A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC29A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC29A4.

Adamsen, D; Ramaekers, V; et al. Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene. MOLECULAR AUTISM 5:-(2014).

Duan, HC; Wang, JN; et al. Impaired monoamine and organic cation uptake in choroid plexus in mice with targeted disruption of the plasma membrane monoamine transporter (Slc29a4)gene. FASEB JOURNAL 27:-(2013).