• Official Full Name
  • SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
  • Background
  • This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene.
  • Synonyms
  • SLX1B; SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae); GIY YIG domain containing 2 , GIYD2; structure-specific endonuclease subunit SLX1; MGC5178; FLJ23439; GIY YIG domain containing 2; GIYD 2; MGC2532; GIY-YIG domain-containing protein 1; GIYD1; GIYD2; SLX1A
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human SLX1B Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SLX1B Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SLX1B Protein, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human GIYD2 293 Cell Lysate

Involved Pathway

SLX1B involved in several pathways and played different roles in them. We selected most pathways SLX1B participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLX1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fanconi anemia pathway
WDR48; C19orf40; RPA3; PMS2; HES1; MLH1; FANCE; TOP3B; ATRIP; CDK5R2

Protein Function

SLX1B has several biochemical functions, for example, 5-flap endonuclease activity, crossover junction endodeoxyribonuclease activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLX1B itself. We selected most functions SLX1B had, and list some proteins which have the same functions with SLX1B. You can find most of the proteins on our site.
Related Protein
Function 5-flap endonuclease activity
Related Protein FAN1; DNA2; FEN1; SLX1B
Function crossover junction endodeoxyribonuclease activity
Related Protein SLX1B; GEN1
Function metal ion binding
Related Protein PAN3; FOXP1B; MKRN4; THOP1; ZFP259; ESYT3; ZNF295; SDHDB; NEK9; AGFG2
Function protein binding

Interacting Protein

SLX1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLX1B here. Most of them are supplied by our site. Hope this information will be useful for your research of SLX1B.
SLX4; ERCC4; MUS81; GRB2; TUBA1B; ribF; q7ckh1_yerpe; sspA; q81zc1_bacan