smad4
Share
  • Official Full Name
  • SMAD family member 4
  • Background
  • SMAD4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. SMAD4 is functionally distinct among the SMAD family, and is required for the assembly and transcriptional activation of diverse, SMAD-DNA complexes. SMAD4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-beta, activin, and bone morphogenetic protein signaling responses. SMAD4 is frequently inactivated in pancreatic, biliary and colorectal tumors.
  • Synonyms
  • SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4; JIP; MADH4; MYHRS
Cat.#:SMAD4-217HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD4 protein, His-tagged
+Inquiry
Cat.#:SMAD4-31192THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD4, His-tagged
+Inquiry
Cat.#:SMAD4-31193THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD4
+Inquiry
Cat.#:SMAD4-386HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 4, His-tagged
+Inquiry
Cat.#:SMAD4-15587MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD4 Protein
+Inquiry
Cat.#:Smad4-1978MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Smad4 protein, His & T7-tagged
+Inquiry
Cat.#:SMAD4-5609RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SMAD4 Protein
+Inquiry
Cat.#:SMAD4-4332RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SMAD4 Protein, His-tagged
+Inquiry
Cat.#:SMAD4-1095HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 4, GST-tagged
+Inquiry
Cat.#:SMAD4-1676HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SMAD4 293 Cell Lysate
+Inquiry

Involved Pathway

SMAD4 involved in several pathways and played different roles in them. We selected most pathways SMAD4 participated on our site, such as FoxO signaling pathway, Cell cycle, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
GRB2; TGFBR1; PIK3R1; EP300; HOMER2; INSB; CCND1; AKT3A; SOD2; PRKAG2A
Cell cycle
SYNE1; ANKLE2; LIN54; MIS18A; GADD45BA; NCAPG; PCM1; RCC2; HDAC5; WRAP53
Wnt signaling pathway
WNT9A; SIAH2L; MAPK10; NKD2B; SFRP4; RHOA; SIAH1; CAMK2D1; CUL1; CUL1B
TGF-beta signaling pathway
ID2; CUL1B; GDF5; BMPR1AA; CUL1A; BMPR1A; GDF6A; INHBA; RBL1; LEFTY1
Hippo signaling pathway
BTRC; ID1; CCND3; MPP5; WWC1; TEAD4; MOBKL1A; FZD10; CTNNA3; APC
Adherens junction
VCLA; WASF2; BAIAP2; FGFR1; RHOAC; TGFBR1; Fert2; SNAI1; PTPN6; ACTN4
Signaling pathways regulating pluripotency of stem cells
FGFR4; INHBA; ID3; HAND1; WNT5B; JARID2; ACVR2A; WNT2; MAPK12; SMAD3
Hepatitis B
CCNE2; CCNA2; TNF; IFIH1; IFNA10; BCL2; NFKB1; PTEN; TLR4; Casp3
HTLV-I infection
PIK3CD; POLD4; PCNA; APC; PIK3CB; XBP1; ITGB2L; POLE2; TNF; WNT2B
Pathways in cancer
BMP2; LAMB1; PIK3CB; CCNE1; ARHGEF1; MTOR; KRAS; ARNT; RXRB; PTGER1
Colorectal cancer
CYCS; RAC2; SMAD3; RAF1; BRAF; MAPK8; PIK3R5; PIK3CG; BAD; CCND1
Pancreatic cancer
RAF1; NFKB1; SMAD3; STAT1; MAPK3; RB1; BRCA2; BAD; RAC2; MAPK8
Chronic myeloid leukemia
TGFB3; SMAD3; MDM2; MECOM; TRP53; CTBP2; CDK6; MAP2K2; PTPN11; BCR

Protein Function

SMAD4 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD4 itself. We selected most functions SMAD4 had, and list some proteins which have the same functions with SMAD4. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to DNA binding
Related Protein CLOCKA; MCM7; GTF3C4; MAFGB; SMAD4; AHR2; RFC3; GTF3C6; MRE11A; ARNTL1B
Function I-SMAD binding
Related Protein SMURF1; TGFB1I1; SMAD1; SMAD4; AXIN1; TGFBR1; CTNNB1; SMAD7; AXIN2; SMAD2
Function R-SMAD binding
Related Protein TRIM33; PPM1A; RANBP3; SMAD4; FOXH1; SMAD3; SMURF1; PAX6; PMEPA1; ZEB2
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein FEZF2; POU2F3; ZNF486; ZNF460; MLXIPL; FOSB; GLI3; NKX3-2; STAT3; TBP
Function RNA polymerase II transcription factor binding
Related Protein CREBBP; GATA3; GSC; KLF4; WWP2; TRPS1; ZFPM2; ZGLP1; DHX9; XBP1
Function chromatin binding
Related Protein MEF2C; EBF2; GATA4; CHD7; TPR; SP140L; SP110; POU5F3; KLHDC3; MEIS1
Function collagen binding
Related Protein PODN; MMP13; SERPINH1B; GP5; MRC2; SERPINH2; CHADL; Itga10&Itgb1; Pdgfa&Pdgfb; PCOLCE2
Function core promoter proximal region sequence-specific DNA binding
Related Protein SP3A; ZFP516; TFAP2A; UHRF1; DMRT3; SMAD4; PAX2; DMRT2B; SP3; DMRTC1B
Function identical protein binding
Related Protein DAPK2; PRNP; ATF3; DYNLT1F; SH3GL1; ATL3; DLC; RASSF1; TPCN2; PAFAH1B3
Function metal ion binding
Related Protein FURIN; PRKAA1; KDM1B; ADCY8; PPP4CB; CDK2; TGM2B; ATF7B; MEP1A.1; CYP11C1
Function protein binding
Related Protein ARL4A; SCLY; UBXN4; GTF2F2; CTSL2; ICA1L; TEAD3; SIM1; CAB39; PLK3
Function protein heterodimerization activity
Related Protein YWHAE; TAS1R1; TFDP3; POU5F3; CEBPA; TCF4; Defa-rs7; HER1; CLCF1; BOKA
Function protein homodimerization activity
Related Protein XDH; MLL1; TIMM9; ADD1; NOS2; MTMR2; SLC4A1; HMGCS1; CHEK2; GSTM4
Function contributes_to sequence-specific DNA binding
Related Protein SMAD4; NEUROD1; PPARG; FIGLA; HIF1A; TRIM28; HDAC4; HNRNPAB; EPAS1; TCF3
Function transcription factor activity, RNA polymerase II transcription factor binding
Related Protein THRAA; MYOCD; MAMSTR; HIF1A; NACC2; ATF4; GTF2E1; ZNF296; GATA4; ATF2
Function contributes_to transcription factor activity, protein binding
Related Protein SMAD4; SMAD3
Function contributes_to transcription factor activity, sequence-specific DNA binding
Related Protein SOX1B; MAFGB; GATA4; NKX2-5; MAFGA; TAF10; SMAD3; SMAD4; SOX19B; VDRA
Function transcription regulatory region DNA binding
Related Protein GATA3; ARID4A; FOS; SALL1A; ASH2L; GATA4; TBL1XR1; SALL3B; TAF7; H2AFY
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein TFAP2C; ESR1; FIGLA; GATA1; NKX2; POU4F2; RFX4; RUNX2; HOXC11; NFIC
Function transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
Related Protein SMAD4

Interacting Protein

SMAD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD4.
SMAD3; SMAD2

SMAD4 Related Gene Family

TGF