smad4
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  • Official Full Name
  • SMAD family member 4
  • Background
  • SMAD4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. SMAD4 is functionally distinct among the SMAD family, and is required for the assembly and transcriptional activation of diverse, SMAD-DNA complexes. SMAD4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-beta, activin, and bone morphogenetic protein signaling responses. SMAD4 is frequently inactivated in pancreatic, biliary and colorectal tumors.
  • Synonyms
  • SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4; JIP; MADH4; MYHRS
Cat.#:SMAD4-217HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD4 protein, His-tagged
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Cat.#:SMAD4-31192THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD4, His-tagged
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Cat.#:SMAD4-31193THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD4
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Cat.#:SMAD4-386HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 4, His-tagged
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Cat.#:SMAD4-15587MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD4 Protein
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Cat.#:Smad4-1978MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Smad4 protein, His & T7-tagged
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Cat.#:SMAD4-5609RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SMAD4 Protein
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Cat.#:SMAD4-4332RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SMAD4 Protein, His-tagged
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Cat.#:SMAD4-1095HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 4, GST-tagged
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Cat.#:SMAD4-1676HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SMAD4 293 Cell Lysate
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Involved Pathway

SMAD4 involved in several pathways and played different roles in them. We selected most pathways SMAD4 participated on our site, such as FoxO signaling pathway, Cell cycle, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
PRKAB2; MAP2K2B; CDKN2D; EP300; STAT3; PLK3; PIK3R3A; RAG2; KRAS; TGFB1A
Cell cycle
ORC6; H3F3D; TOP2A; RANGAP1B; CHEK2; CDC25C; CCDC99; CEP135; KIF18A; GINS3
Wnt signaling pathway
WNT2; CCND3; PRKCBA; CSNK1A1L; PRKACB; MAPK10; PPP3CCB; BAMBIA; PRICKLE1A; WNT6
TGF-beta signaling pathway
ROCK2B; PPP2R1B; SMAD9; ACVR2A; NOG; LFT1; BMP4; SKP1; TGIF1; AMH
Hippo signaling pathway
GLI2; WNT3; PARD6A; TGFBR2; WWTR1; CTGF; PPP2CB; YAP1; ITGB2L; SOX2
Adherens junction
TCF7; CDC42; ACTB; PARD3; FER; EGFR; TCF7L2; ACTN2B; PTPRFB; CDC42L
Signaling pathways regulating pluripotency of stem cells
WNT3A; FZD9; WNT10B; Fzd4; ZFHX3; WNT7B; WNT4; FGFR1; MAPK12; ACVR1C
Hepatitis B
YWHAB; BIRC5; IFNAR1; NFATC2; IFNA14; SMAD3; CXCL8; HBXIP; DDX58; HRAS
HTLV-I infection
RELB; CCND2; PRKACB; CCND3; WNT10B; APC; VCAM1; POLE3; FZD10; VDAC1
Pathways in cancer
FZD3; PIK3R3; ITGA2; GNB4; PLCG1; ITGA2B; RB1; MAP2K2; HSP90B1; GNGT2
Colorectal cancer
MAPK8; MSH6; DCC; AKT2; MSH2; TCF7L2; MAPK1; CASP9; MAPK10; PIK3CG
Pancreatic cancer
SMAD4; TP53; ARHGEF6; AKT2; PIK3R3; RALB; MAPK1; CDC42; SMAD3; BRCA2
Chronic myeloid leukemia
CTBP2; ABL1; PTPN11; RELA; IKBKB; HDAC2; SHC1; CBLB; TRP53; TGFB1

Protein Function

SMAD4 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD4 itself. We selected most functions SMAD4 had, and list some proteins which have the same functions with SMAD4. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to DNA binding
Related Protein MAFGA; ARNTL1B; TCF3; CLOCKA; SMAD4; GTF3C2; AHR2; GTF3C6; RFC3; NFE2L2A
Function I-SMAD binding
Related Protein SMAD2; SMAD7; SMAD6; SMAD1; AXIN2; CTNNB1; SMURF1; TGFBR1; TGFB1I1; SMAD4
Function R-SMAD binding
Related Protein PPM1A; MEN1; RANBP3; MYOCD; JUN; SMAD3; ZC3H3; SMAD2; FOXH1; PARP1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein GLI2; PLAG1; NKX6; SIX2; SMAD1; AEBP2; MITFA; RFX4; POU1F1; GCFC2
Function RNA polymerase II transcription factor binding
Related Protein MKX; GFI1B; GATA2B; HCLS1; GATA1; KLF4; XBP1; TBX3; ZGLP1; MTA2
Function chromatin binding
Related Protein ANKRD2; ELK4; SUZ12; GPR30; TSHZ3; HINFP; HMGB4; OST4; ATXN7; EBF2
Function collagen binding
Related Protein DDR1; CTSK; ASPN; PDGFA; GP5; ACHE; ITGA2; SMAD7; VWF; PAK1
Function core promoter proximal region sequence-specific DNA binding
Related Protein CREBBP; DMRT3A; SMAD4; DMRTA2; DMRTC1B; KLF4; MIXL1; DMRT3; DMRTC2; SP3
Function identical protein binding
Related Protein CBY1; KIRRELA; PON2; PLK4; VIL1; ASS1; CSK; SIRT1; RYR2; TPRG1L
Function metal ion binding
Related Protein KLF2; SCNM1-PS; ZBTB48; BCL11B; AMPD1; ZBED6; CDC7; PAPOLG; KDM2AA; GTF3A
Function protein binding
Related Protein CCL28; IL6ST; CRABP2; CTSK; STARD3; PJA1; KCTD15; TXNRD3; RPL27A; Icosl
Function protein heterodimerization activity
Related Protein ERBB3; NR4A1; RRAGA; ANO9A; TGFB3; Defa-rs7; SMAD3; SNX6; LIFR; HIST1H3G
Function protein homodimerization activity
Related Protein CADM4; MID2; SP100; BMPR1A; GZMA; Il6ra; BAX; BCL2L1; NETO2; S100A16
Function contributes_to sequence-specific DNA binding
Related Protein HIF1A; ARNT; NEUROD1; HNRNPAB; SMAD4; EPAS1; TRIM28; FIGLA; HDAC4; PPARG
Function transcription factor activity, RNA polymerase II transcription factor binding
Related Protein TWIST2; THRAA; GTF2E1; ATF2; ZNF296; GATA4; ATF4; YAP1; MAMSTR; SMAD4
Function contributes_to transcription factor activity, protein binding
Related Protein SMAD4; SMAD3
Function contributes_to transcription factor activity, sequence-specific DNA binding
Related Protein GATA4; SOX1B; SOX1A; TAF6; SMAD4; NKX2; SMAD3; HNRNPAB; FOXH1; VDRA
Function transcription regulatory region DNA binding
Related Protein ARID4A; ZNF613; ZFP335; GABPA; ZNF831; FOXM1; MTERFD1; HHEX; ERBB4; PAX2
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein NRF1; SP1; NFIC; MEOX1; ONECUT1; CEBPA; ZFP639; TFAP2B; LEF1; MAFA
Function transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
Related Protein SMAD4

Interacting Protein

SMAD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD4.
SMAD3; SMAD2

SMAD4 Related Gene Family

TGF