smc3
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  • Official Full Name
  • structural maintenance of chromosomes 3
  • Background
  • This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]
  • Synonyms
  • SMC3; structural maintenance of chromosomes 3; BAM; BMH; HCAP; CDLS3; CSPG6; SMC3L1; structural maintenance of chromosomes protein 3; SMC protein 3; chromosome-associated polypeptide; chondroitin sulfate proteoglycan 6 (bamacan); basement membrane-associated chondroitin proteoglycan;
Cat.#:SMC3-1541HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMC3 protein, His & T7-tagged
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Cat.#:SMC3-20HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SMC3, GST-tagged
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Cat.#:SMC3-2810HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMC3, His-tagged
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Cat.#:SMC3-31196THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMC3, His-tagged
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Cat.#:SMC3-6086CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SMC3
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Cat.#:SMC3-12720ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SMC3
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Cat.#:SMC3-1648HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SMC3 cell lysate
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Involved Pathway

SMC3 involved in several pathways and played different roles in them. We selected most pathways SMC3 participated on our site, such as Cell cycle, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
KIF20A; E2F3; CDC7; CDC6; YWHABB; POLD3; HIST4H4; NINL; NPM1; CDKN2D
Oocyte meiosis
BUB1; Ar; FBXO5; CUL1; PPP1CAB; PPP3CCB; YWHAQB; CAMK2D2; ESPL1; REC8

Protein Function

SMC3 has several biochemical functions, for example, ATP binding, chromatin binding, dynein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMC3 itself. We selected most functions SMC3 had, and list some proteins which have the same functions with SMC3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein YRK; ATP1A1; ABCA5; RTEL1; ACSM3; IP6K1; RAD51L3; PIK3C2B; TK1; TOR2A
Function chromatin binding
Related Protein MITF; MSL1; ATAD2; KDM5A; STAG1; SFPQ; NKX2-5; NPM2; JUB; SMC1AL
Function dynein binding
Related Protein KATNA1; KATNB1; BICD1; LRRC50; DCTN6; DCTN1; PAFAH1B1; SNCA; SERPINB1A; WDR43
Function mediator complex binding
Related Protein NIPBL; SMC3; MED1; SMC1A
Function microtubule motor activity
Related Protein KIFC1; DYNC1LI1; SMC3; KIF3CB; KIF7; KIF4; SMC1A; KIF27; DYNC1I2; KIF14
Function protein binding
Related Protein DHDDS; RG9MTD1; PJA1; BCL2L10; SCN11A; CNBP; EDDM3B; INTS4; HOXA9; TNFSF14
Function protein heterodimerization activity
Related Protein SOX6; HIST1H2A9; PVRL1; YWHAE; SDCBP; INHA; NFKB1; PPP2R1A; SIM1; CEBPE

Interacting Protein

SMC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMC3.
RAD21; STAG1

SMC3 Related Articles

Bermudez, VP; Farina, A; et al. In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109:9366-9371(2012).
del Cacho, E; Gallego, M; et al. Location of RAD51-like protein during meiotic prophase in Eimeria tenella. VETERINARY PARASITOLOGY 178:77-85(2011).