Recombinant Human SMC3, GST-tagged

• Cat.No.: SMC3-20H
• Product Overview: Recombinant Human SMC3(711 a.a. - 810 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: GST
• Description: This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.
• Molecular Mass: 36.63 kDa
• AA Sequence: IDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDL LSQLSLEDQKRVDALNDEIRQLQQE
• Applications: ELISA; WB-Re; AP; Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80ºC. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: SMC3 structural maintenance of chromosomes 3 [ Homo sapiens (human) ]
• Official Symbol: SMC3
• Synonyms: SMC3; structural maintenance of chromosomes 3; chondroitin sulfate proteoglycan 6 (bamacan) , CSPG6; structural maintenance of chromosomes protein 3; BAM; bamacan; bamacan proteoglycan; HCAP; SMC3L1; SMC-3; SMC protein 3; chromosome-associated polypeptide; chondroitin sulfate proteoglycan 6 (bamacan); basement membrane-associated chondroitin proteoglycan; BMH; CDLS3; CSPG6
• Gene ID: 9126
• mRNA Refseq: NM_005445
• Protein Refseq: NP_005436
• MIM: 606062
• UniProt ID: Q9UQE7
• Chromosome Location: 10q25
• Pathway: Cohesin Loading onto Chromatin; Establishment of Sister Chromatid Cohesion; Mitotic Prometaphase; Oocyte meiosis
• Function: ATP binding; chromatin binding; mediator complex binding