SPRY4 Protein, sprouty homolog 4


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Official Full Name sprouty homolog 4
Background SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is;positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et;al., 2002 (PubMed 12027893)).
Synonyms SPRY4; sprouty homolog 4 (Drosophila); protein sprouty homolog 4; spry-4
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SPRY4-2326H Recombinant Human SPRY4 protein, His-tagged E.coli His
    Human SPRY4-2939H Recombinant Human SPRY4, His-tagged E.coli His
    Mouse SPRY4-15946M Recombinant Mouse SPRY4 Protein Mammalian Cell His
    Chicken SPRY4-3568C Recombinant Chicken SPRY4 Mammalian Cell His
    Zebrafish SPRY4-9335Z Recombinant Zebrafish SPRY4 Mammalian Cell His

    SPRY4 involved in several pathways and played different roles in them. We selected most pathways SPRY4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPRY4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    SPRY4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPRY4 itself. We selected most functions SPRY4 had, and list some proteins which have the same functions with SPRY4. You can find most of the proteins on our site.

    Function Related Protein
    protein binding C14orf118; Tnfrsf22; NUDC; DHX15; IDE; MKRN3; ARF1; CTAGE5; HPSE; RBKS

    SPRY4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPRY4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPRY4.


    Gromova, P; Ralea, S; et al. Kit K641E oncogene up-regulates Sprouty homolog 4 and Trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 13:1536-1548(2009).

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