srebf2
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  • Official Full Name
  • sterol regulatory element binding transcription factor 2
  • Background
  • This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
  • Synonyms
  • SREBF2; sterol regulatory element binding transcription factor 2; sterol regulatory element-binding protein 2; bHLHd2; SREBP2; AI608257; Class D basic helix-loop-helix protein 2; OTTHUMP00000028740; Processed sterol regulatory element-binding protein 2; SRBP2_HUMAN; SREBF 2; SREBF2 protein; SREBP 2; SREBP-2; SREBP2gc; sterol regulatory element binding factor 2; Sterol regulatory element binding protein 2; Sterol regulatory element-binding transcription factor 2
Cat.#:SREBF2-31395THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SREBF2
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Cat.#:SREBF2-15974MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SREBF2 Protein
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Cat.#:SREBF2-5737RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SREBF2 Protein
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Cat.#:SREBF2-5575ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SREBF2
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Involved Pathway

SREBF2 involved in several pathways and played different roles in them. We selected most pathways SREBF2 participated on our site, such as Activation of gene expression by SREBF (SREBP), Cholesterol biosynthesis, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with SREBF2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of gene expression by SREBF (SREBP)
PMVK; NFYAL; MTF1; NFYBB; NCOA2; CARM1; DHCR7; HELZ2; SREBF2; NFYBA
Cholesterol biosynthesis
CYP51A1; DHCR24; LBR; ARV1; SREBF2; DHCR7; PMVK; EBP
Developmental Biology
COL6A1; KIF4; PLXNC1; EFNA3B; MEF2AA; EFNB2A; HELZ2; SMAD3B; DNM2; EFNA1
Fatty acid, triacylglycerol, and ketone body metabolism
CYP7A1; TIAM2; PLIN2; MED29; MED19; MED26; CPT2; SIN3B; ECI1; ABCA1
Metabolism
KCNC2; KHK; MARCKSB; SLC5A9; ACSM1; ACER1; UCP2; NDUFAF6; GLRX; CHP
Metabolism of lipids and lipoproteins
PMVK; MED26; ACOT11A; MED9; LPA; CYP2AD6; GLTPA; ACAD11; ACOT2; NFYBA
PPARA activates gene expression
APOA5; MED6; MED21; MED20; MED26; MED7; GRHL1; MED18; MED31; SREBF2
Regulation of cholesterol biosynthesis by SREBP (SREBF)
MTF1; NFYAL; INSIG1; DHCR7; NFYBA; YY2; INSIG2; PMVK; SREBF2; NFYBB

Protein Function

SREBF2 has several biochemical functions, for example, NOT C-8 sterol isomerase activity, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SREBF2 itself. We selected most functions SREBF2 had, and list some proteins which have the same functions with SREBF2. You can find most of the proteins on our site.
Function
Related Protein
Function NOT C-8 sterol isomerase activity
Related Protein SREBF2
Function E-box binding
Related Protein NEUROG1; NEUROG2; NEUROD1; TWIST1; TAL1; TCF4; TFAP4; BHLHE40; ZEB1; ASCL2
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein TFE3A; MYC; EBF2; ELK3; ZNF100; NR2C1; NKX2-5; PITX2; PHOX2B; NKX6-1
Function protein C-terminus binding
Related Protein ZBTB16; TAF13; RBFOX1; PPP2CA; PEX26; MAP2K1; PIAS4; PFKM; HESX1; VAMP2
Function protein binding
Related Protein BLM; EFCAB4A; KRT1; CTSB; FKBP1B; TMEM59; L3MBTL1; SERPINA1A; HNRNPA1; IFNAR2
Function protein dimerization activity
Related Protein MITFA; ATOH7; MESP1; POLR1C; ID2; NEUROG2; NEUROD6B; HER2; MYO5A; SOHLH1
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein CUX2; SP3; NR1D1; POU4F2; SNAI2; GATA1; SALL1; IFI16; PROX1; PROX1A

Interacting Protein

SREBF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SREBF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SREBF2.
SP1; HNF4A; TP53; ldlr_human_sre_dna-probe; Kpnb1; HNF4A; SMAD3; b3kqf8_human; ABLIM1; PIAS1; PIAS2; HSPA5

SREBF2 Related Articles

Barderas, R; Babel, I; et al. An optimized predictor panel for colorectal cancer diagnosis based on the combination of tumor-associated antigens obtained from protein and phage microarrays. JOURNAL OF PROTEOMICS 75:4647-4655(2012).
Khaidakov, M; Mitra, S; et al. Oxidized LDL Receptor 1 (OLR1) as a Possible Link between Obesity, Dyslipidemia and Cancer. PLOS ONE 6:-(2011).
Babel, I; Barderas, R; et al. Identification of MST1/STK4 and SULF1 Proteins as Autoantibody Targets for the Diagnosis of Colorectal Cancer by Using Phage Microarrays. MOLECULAR & CELLULAR PROTEOMICS 10:-(2011).