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ST8SIA2

Official Full Name

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Overview

The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29.
Synonyms

ST8SIA2; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; sialyltransferase 8 (alpha 2, 8 sialytransferase) B , SIAT8B; alpha-2,8-sialyltransferase 8B; HsT19690; ST8SIA II; STX; SIAT8-B; ST8SiaII; sialyltransferase X; sialyltransferase 8B; si;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Mus musculus (Mouse)
Pan troglodytes (Chimpanzee)
Rat
Zebrafish

Source

E.coli expression system
E.Coli or Yeast
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A
N
6×His, GFP

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ST8SIA2-1433HCL	Recombinant Human ST8SIA2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ST8SIA2-20H	Recombinant Human ST8SIA2 Protein (AA 60-375), N-6×His/GFP tagged	HEK293	N-6×His, GFP	AA 60-375	Inquiry
Mouse	St8sia2-3320M	Recombinant Mouse St8sia2, His-tagged	E.Coli or Yeast	His	375	Inquiry
Mouse	ST8SIA2-16079M	Recombinant Mouse ST8SIA2 Protein	Mammalian Cell	His		Inquiry
Mouse	ST8SIA2-8766M	Recombinant Mouse ST8SIA2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	ST8SIA2-8766M-B	Recombinant Mouse ST8SIA2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	ST8SIA2-5773R	Recombinant Rat ST8SIA2 Protein	Mammalian Cell	His		Inquiry
Rat	ST8SIA2-5432R	Recombinant Rat ST8SIA2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	ST8SIA2-5432R-B	Recombinant Rat ST8SIA2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mus musculus (Mouse)	RFL33580MF	Recombinant Full Length Mouse Alpha-2,8-Sialyltransferase 8B(St8Sia2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-375)	Inquiry
Pan troglodytes (Chimpanzee)	ST8SIA2-3319P	Recombinant Pan troglodytes (Chimpanzee) ST8SIA2, His-tagged	E.Coli or Yeast	His	375	Inquiry
Zebrafish	ST8SIA2-9469Z	Recombinant Zebrafish ST8SIA2	Mammalian Cell	His		Inquiry
Chicken	ST8SIA2-1123C	Recombinant Chicken ST8SIA2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ST8SIA2 Related Articles

ST8SIA2 involved in several pathways and played different roles in them. We selected most pathways ST8SIA2 participated on our site, such as Asparagine N-linked glycosylation, Axon guidance, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST8SIA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Asparagine N-linked glycosylation	SEC23A;ST3GAL3A;ST6GALNAC1.2;TRAPPC5;PPP6C;TMED2;MPDU1A;NAPG;ST8SIA3
Axon guidance	SEMA3G;PPP3CA;EPHA10;PSPN;NFATC4;PPP3R1;RHOAE;RGMA;ITGB3A
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	MPDU1B;ST6GALNAC2;MPDU1;ZNF408;GNE;DPAGT1;ALG10B;ALG2;NEU4
Developmental Biology	DPYSL5A;FRS2B;KIF4A;GFRA2;TRPC3;INSM1A;SCN2A;SPNA1;EVL
Metabolism of proteins	TRAPPC1;KCNA3;PPP6R3;SEC63;TOMM22;RAB27A;CMA1;DPAGT1;GCNT3
N-Glycan antennae elongation	ST8SIA3;ST8SIA2;MGAT4A;MGAT4B
N-glycan antennae elongation in the medial/trans-Golgi	ST8SIA2;ST8SIA3;MGAT4B;MGAT4A
NCAM signaling for neurite out-growth	GFRA1;GFRA4;GFRA2;GDNF;NRTN;ST8SIA2;COL9A1B;PSPN;COL9A1A

ST8SIA2 has several biochemical functions, for example, alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity, sialic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ST8SIA2 itself. We selected most functions ST8SIA2 had, and list some proteins which have the same functions with ST8SIA2. You can find most of the proteins on our site.

Function	Related Protein
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	ST8SIA5;ST8SIA3;ST8SIA1;ST8SIA2
sialic acid binding	Siglece;SELE;ADIPOQ;FCN1;AGRN;ST8SIA3;L1CAM;ST8SIA2;SELP

ST8SIA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST8SIA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST8SIA2.

Matarrese, P; Garofalo, T; et al. Evidence for the involvement of GD3 ganglioside in autophagosome formation and maturation. AUTOPHAGY 10:750-765(2014).

Hamada, Y; Saigoh, K; et al. Circadian expression and specific localization of a sialyltransferase gene in the suprachiasmatic nucleus. NEUROSCIENCE LETTERS 535:12-17(2013).

Lee, MTM; Chen, CH; et al. Genome-wide association study of bipolar I disorder in the Han Chinese population. MOLECULAR PSYCHIATRY 16:548-556(2011).

Husain, S; Yildirim-Toruner, C; et al. Variants of ST8SIA1 Are Associated with Risk of Developing Multiple Sclerosis. PLOS ONE 3:-(2008).