ST8SIA2 Protein, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2


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Official Full Name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Background The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29.
Synonyms ST8SIA2; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; sialyltransferase 8 (alpha 2, 8 sialytransferase) B , SIAT8B; alpha-2,8-sialyltransferase 8B; HsT19690; ST8SIA II; STX; SIAT8-B; ST8SiaII; sialyltransferase X; sialyltransferase 8B; si
    • Species :
    • Chicken
    • Human
    • Mouse
    • Pan troglodytes (Chimpanzee)
    • Rat
    • Zebrafish
    • Source :
    • E.Coli or Yeast
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ST8SIA2-1433HCL Recombinant Human ST8SIA2 293 Cell Lysate HEK293 N/A
    Mouse ST8SIA2-16079M Recombinant Mouse ST8SIA2 Protein Mammalian Cell His
    Mouse St8sia2-3320M Recombinant Mouse St8sia2, His-tagged E.Coli or Yeast His
    Rat ST8SIA2-5773R Recombinant Rat ST8SIA2 Protein Mammalian Cell His
    Chicken ST8SIA2-1123C Recombinant Chicken ST8SIA2 Mammalian Cell His
    Zebrafish ST8SIA2-9469Z Recombinant Zebrafish ST8SIA2 Mammalian Cell His
    Pan troglodytes (Chimpanzee) ST8SIA2-3319P Recombinant Pan troglodytes (Chimpanzee) ST8SIA2, His-tagged E.Coli or Yeast His

    ST8SIA2 involved in several pathways and played different roles in them. We selected most pathways ST8SIA2 participated on our site, such as Asparagine N-linked glycosylation, Axon guidance, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST8SIA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Asparagine N-linked glycosylation MCFD2; TMED2; PPP6C; MPDU1B; ST6GAL2B; SEC22C; MPDU1A; TFG; DPAGT1; TRAPPC2L
    Axon guidance MARK3; LOC608458; PAK6; JAK1; Unc5b; CSNK2A1; LIMK1; DLG3; DPYSL4; SEMA5A
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein ALG10B; MPDU1; ZNF408; ST3GAL3A; ST6GALNAC1.2; ST8SIA2; NANP; MPDU1B; DPAGT1; GNE
    Developmental Biology MYL12A; COL4A4; EFNB2; LGI4; CHL1; SPTA1; CDK8; ARPC5; SEMA3AB; CSNK2A2
    Metabolism of proteins ARSH; PFDN6; DOHH; PCSK2; GALNTL2; DNAJB9; CTSH; GCNT3; TRAPPC4; FBXL5
    N-Glycan antennae elongation MGAT4B; ST8SIA3; MGAT4A; ST8SIA2
    N-glycan antennae elongation in the medial/trans-Golgi MGAT4B; ST8SIA2; MGAT4A; ST8SIA3
    NCAM signaling for neurite out-growth COL9A1B; COL9A1A; GDNF; ST8SIA2; PSPN; NRTN; GFRA2; GFRA4; GFRA1

    ST8SIA2 has several biochemical functions, for example, alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity, sialic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ST8SIA2 itself. We selected most functions ST8SIA2 had, and list some proteins which have the same functions with ST8SIA2. You can find most of the proteins on our site.

    Function Related Protein
    alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ST8SIA5; ST8SIA2; ST8SIA3; ST8SIA1
    sialic acid binding ADIPOQ; L1CAM; Siglece; FCN1; SELE; ST8SIA2; AGRN; SELP; ST8SIA3

    ST8SIA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST8SIA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST8SIA2.

    Matarrese, P; Garofalo, T; et al. Evidence for the involvement of GD3 ganglioside in autophagosome formation and maturation. AUTOPHAGY 10:750-765(2014).
    Hamada, Y; Saigoh, K; et al. Circadian expression and specific localization of a sialyltransferase gene in the suprachiasmatic nucleus. NEUROSCIENCE LETTERS 535:12-17(2013).
    Lee, MTM; Chen, CH; et al. Genome-wide association study of bipolar I disorder in the Han Chinese population. MOLECULAR PSYCHIATRY 16:548-556(2011).
    Husain, S; Yildirim-Toruner, C; et al. Variants of ST8SIA1 Are Associated with Risk of Developing Multiple Sclerosis. PLOS ONE 3:-(2008).

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