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STAG2

Official Full Name

stromal antigen 2
Overview

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Synonyms

STAG2; stromal antigen 2; cohesin subunit SA-2; SA 2; SCC3B; SCC3 homolog 2; SA2; SA-2; bA517O1.1; FLJ25871; DKFZp686P168; DKFZp781H1753;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	STAG2-2987H	Recombinant Human STAG2, GST-tagged	E.coli	GST	1046-1171aa	$319 / 25ug
Human	STAG2-2438H	Recombinant Human STAG2 protein, His-tagged	E.coli	His	1047-1172 aa	$319 / 25ug
Human	STAG2-2740H	Recombinant Human STAG2 Protein, His-tagged	E.coli	N-His	Met1-Leu268	Inquiry
Mouse	STAG2-16090M	Recombinant Mouse STAG2 Protein	Mammalian Cell	His		Inquiry
Mouse	STAG2-8772M	Recombinant Mouse STAG2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	STAG2-8772M-B	Recombinant Mouse STAG2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

STAG2 involved in several pathways and played different roles in them. We selected most pathways STAG2 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Cohesin Loading onto Chromatin, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell Cycle	TP53BP1;NDE1;CUL1A;WAPAL;ANAPC7;CCND2;CDK11B;EP300;NUP50
Cell Cycle, Mitotic	NCAPG;NDE1;CENPL;CTDNEP1;PLK4;GINS4;TCTN2;CSNK2B;TUBB4A
Cohesin Loading onto Chromatin	STAG1;WAPAL;MAU2;PDS5B;NIPBL;PDS5A;NIPBLB;NIPBLA;STAG2
Establishment of Sister Chromatid Cohesion	PDS5B;WAPAL;ESCO1;STAG2;CDCA5;ESCO2;STAG1;PDS5A
M Phase	AHCTF1;SETB;TMEM188;PMF1;CENPK;DULLARD;GORASP2;SPC25;CDCA5
Meiosis	SYCP2;FKBP6;TERF2IP;TEX12;DIDO1;STAG1;MSH4;ACD;SYNE1
Meiotic synapsis	TERF2;SYCE1;SYCE2;SYCP1;SYCP2;SYNE2;STAG2;SUN2;ACD

STAG2 has several biochemical functions, for example, chromatin binding, protein binding, transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAG2 itself. We selected most functions STAG2 had, and list some proteins which have the same functions with STAG2. You can find most of the proteins on our site.

Function	Related Protein
chromatin binding	TWIST2;ZNF143;NAP1L2;PBX2;FOXO1;HMGB1;STAG2;TOP2A;NCOA1
protein binding	ASPH;SALL2;SNF8;SELPLG;C10orf35;FEM1B;TIPRL;PIR;ZBED4
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	ARID3A;FOXF1;SOHLH2;GATA1;GATA1A;HIF1A;MYOD1;ALX1;CEBPA

STAG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAG2.

SMC3; RAD21; SMC1A