stk3
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  • Official Full Name
  • serine/threonine kinase 3
  • Background
  • This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein;functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal;portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which;promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have;been found for this gene.
  • Synonyms
  • STK3; serine/threonine kinase 3; serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; KRS1; MST2; MST-2; STE20-like kinase MST2; mammalian STE20-like protein kinase 2; serine/threonine-protein kinase Krs-1; serine/threonine
Cat.#:Stk3-669HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Stk3 Protein, His-tagged
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Cat.#:STK3-437HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human STK3, GST-tagged, Active
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Cat.#:STK3-16139MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse STK3 Protein
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Cat.#:STK3-5793RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat STK3 Protein
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Cat.#:STK3-4527RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey STK3 Protein, His-tagged
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Cat.#:STK3-2991CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken STK3
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Cat.#:STK3-10071ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish STK3
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Cat.#:STK3-731HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Serine/threonine Kinase 3 (STE20 Homolog, Yeast)
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Cat.#:STK3-1486HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human STK3 (Active), GST-tagged
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Cat.#:STK3-1405HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human STK3 293 Cell Lysate
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Involved Pathway

STK3 involved in several pathways and played different roles in them. We selected most pathways STK3 participated on our site, such as MAPK signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
C11orf52; MEF2CA; MKNK2A; SRF; RPS6KA4; PTPN7; AKT2L; RPS6KA6; HSC70; FGF12A
Hippo signaling pathway
BMP6; GDF5; CCND2; CCND3; GSK3B; PPP2R1B; MOBKL1A; WNT3; YWHAE; LLGL2

Protein Function

STK3 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STK3 itself. We selected most functions STK3 had, and list some proteins which have the same functions with STK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2E2; ERCC6L2; MSH5; FDXACB1; SHPRH; MAP4K1; TGFBR2; PRKCQ; PSMC1A; TRIO
Function MAP kinase kinase kinase activity
Related Protein MAP3K6; MAP3K4; TAOK3; MOS; MAP3K14; EGFR; MAP3K3; TAOK2; MAP3K5; MAP3K2
Function magnesium ion binding
Related Protein ZNF143B; EYA2; LATS1; FARS2; TOP2A; ARF1; PRPS1L1; WEE2; ENOPH1; GSS
Function protein binding
Related Protein ELP3; CRK; ING4; MAZ; RPGRIP1L; RAP1GDS1; HSPA1B; SIGLEC8; RNF19B; GTF3C6
Function protein dimerization activity
Related Protein ARNTL; MEF2CA; AHR1A; NEUROD6A; STAT3; TFE3A; SRFB; RIMKLB; DAO; SMG1
Function protein kinase activity
Related Protein TRIO; TSSK5; MAPK8B; TGFBR1; BRAF; CLK4B; CDK11A; MAP4K6; PIK3CG; PPP1R9B
Function protein serine/threonine kinase activator activity
Related Protein CALM1; SPRY2; CALM2; PARP16; MAP2K2; ALS2; CAB39; MAP2K1; CALM3; STRADA
Function protein serine/threonine kinase activity
Related Protein AKT2L; MAPK11; STRC; MYLK4; RPS6KA5; GRK7B; BMPR1AB; STK38L; ADCK1; DCLK2

Interacting Protein

STK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of STK3.
SAV1; STK4

STK3 Related Articles

Hammer, A; Oladimeji, P; et al. Phosphorylation of tyrosine 285 of PAK1 facilitates beta PIX/GIT1 binding and adhesion turnover. FASEB JOURNAL 29:943-959(2015).
Kamato, D; Rostam, MA; et al. Transforming growth factor beta-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells. JOURNAL OF PHARMACY AND PHARMACOLOGY 66:1722-1733(2014).