TDP1
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Official Full Name
tyrosyl-DNA phosphodiesterase 1
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Overview
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. -
Synonyms
TDP1; tyrosyl-DNA phosphodiesterase 1; FLJ11090; SCAN1; AI838772; AW493413; MGC104252; MGC112732; RP24-311F12.2; TYDP; TYDP1_HUMAN; Tyr-DNA phosphodiesterase 1; OTTHUMP00000244881; OTTHUMP00000244883; OTTHUMP00000244885; OTTHUMP00000244892;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293 cells
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
TDP1 involved in several pathways and played different roles in them. We selected most pathways TDP1 participated on our site, such as DNA Double-Strand Break Repair, DNA Repair, Nonhomologous End-Joining (NHEJ), which may be useful for your reference. Also, other proteins which involved in the same pathway with TDP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Double-Strand Break Repair | TIPIN;TDP1;RAD9B;EME1;CHEK1;TIMELESS;UIMC1;POLD3;RAD17 |
| DNA Repair | EYA3;RNF4;DTL;ALKBH2;PARP2;PPP4R2B;RNF111;ELL;MAD2L2 |
| Nonhomologous End-Joining (NHEJ) | TDP2;TDP1;RIF1;PAXIP1;TDP2B |
TDP1 has several biochemical functions, for example, 3-tyrosyl-DNA phosphodiesterase activity, double-stranded DNA binding, exonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TDP1 itself. We selected most functions TDP1 had, and list some proteins which have the same functions with TDP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-tyrosyl-DNA phosphodiesterase activity | |
| double-stranded DNA binding | MTERFD2;XRCC3;TEF;HES2;NKX2-8;LSM14A;TP63;RAD51L1;HNRNPDL |
| exonuclease activity | AEN;REXO1L1;ISG20;RAD9;ISG20L2;CNOT6;REX1;DOM3Z;MEIOB |
| protein binding | SDC2;KRTAP10-8;XRCC4;YOD1;PMEPA1;LRRC4;P4HB;KLHL20;NUMB |
| single-stranded DNA binding | HNRNPDL;HMGB2;SETMAR;DDX11;MLH3;POLR2G;TDP1;TREX1;RBMS1 |
TDP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TDP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TDP1.
XRCC1; ssdna_dcdg; TRIM33; H2AFX; ATM
- Q&As
- Reviews
Q&As (4)
Ask a questionInhibition of TDP1 expression induces apoptosis in gastric cancer cells.
TDP1 has been closely associated with the study of diseases such as gastric cancer and lung cancer.
Lung adenocarcinoma tissues expressed higher levels of TDP1 compared to paraneoplastic and normal tissues.
TDP1 is involved in DNA damage repair and plays a driving role in tumorigenesis and development.
Customer Reviews (3)
Write a reviewVery professional customer service, fully understanding the needs of the customer and giving professional advice.
The technical expert will follow up on the progress of my experiments and provide constructive advice on the problems that arise in my experiments.
Fast and timely shipment helped me to get satisfactory experimental results in short time.
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