TDP1 Protein, tyrosyl-DNA phosphodiesterase 1


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Official Full Name tyrosyl-DNA phosphodiesterase 1
Background The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Synonyms TDP1; tyrosyl-DNA phosphodiesterase 1; FLJ11090; SCAN1; AI838772; AW493413; MGC104252; MGC112732; RP24-311F12.2; TYDP; TYDP1_HUMAN; Tyr-DNA phosphodiesterase 1; OTTHUMP00000244881; OTTHUMP00000244883; OTTHUMP00000244885; OTTHUMP00000244892
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293 cells
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TDP1-3325H Recombinant Human TDP1 Protein, GST-tagged Wheat Germ GST
    Human TDP1-3326H Recombinant Human TDP1 Protein, Flag-tagged HEK293 cells Flag
    Human TDP1-3327H Recombinant Human TDP1 Protein, Flag-tagged HEK293 cells Flag
    Mouse Tdp1-270M Recombinant Mouse Tdp1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human TDP1-3328H Recombinant Human TDP1 Protein E.coli
    Human TDP1-1155HCL Recombinant Human TDP1 293 Cell Lysate HEK293 N/A
    Human TDP1-7250H Recombinant Human TDP1, His-tagged E.coli His
    Mouse Tdp1-8069M Recombinant Mouse Tdp1 protein, His & GST-tagged E.coli His/GST
    Rat Tdp1-1668R Recombinant Rat Tdp1 protein, His & GST-tagged E.coli His/GST
    Rat TDP1-5998R Recombinant Rat TDP1 Protein Mammalian Cell His
    Rhesus Macaque TDP1-4660R Recombinant Rhesus monkey TDP1 Protein, His-tagged Mammalian Cell His

    TDP1 involved in several pathways and played different roles in them. We selected most pathways TDP1 participated on our site, such as DNA Double-Strand Break Repair, DNA Repair, Nonhomologous End-Joining (NHEJ), which may be useful for your reference. Also, other proteins which involved in the same pathway with TDP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DNA Double-Strand Break Repair CHEK2; FUZ; RIF1; PARP2; EYA3; FAM175A; RAD9A; HUS1; CHEK1; EME2
    Nonhomologous End-Joining (NHEJ) TDP2; PAXIP1; TDP2B; RIF1; TDP1

    TDP1 has several biochemical functions, for example, 3-tyrosyl-DNA phosphodiesterase activity, double-stranded DNA binding, exonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TDP1 itself. We selected most functions TDP1 had, and list some proteins which have the same functions with TDP1. You can find most of the proteins on our site.

    Function Related Protein
    3-tyrosyl-DNA phosphodiesterase activity TDP1
    double-stranded DNA binding USF1; HES2; GTF2H4; TARDBP; LSM14A; EGFR; XRCC2; IFI203; HNRPDL; SMAD2
    exonuclease activity EXO5; RAD9; WRN; ISG20; EXO1; CNOT6; TDP1; CNOT6L; DOM3Z; ISG20L2
    single-stranded DNA binding DDX11; HMGB1; PEO1; NME2; HNRNPA1; CDAN1; SSBP3; FUBP1; RAD51AP1; CNBPA

    TDP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TDP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TDP1.

    XRCC1; ssdna_dcdg; TRIM33; H2AFX; ATM

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