TERF1
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Official Full Name
telomeric repeat binding factor (NIMA-interacting) 1 -
Overview
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008] -
Synonyms
TERF1;telomeric repeat binding factor (NIMA-interacting) 1;TRF;PIN2;TRF1;TRBF1;t-TRF1;hTRF1-AS;telomeric repeat-binding factor 1;NIMA-interacting protein 2;telomeric protein Pin2/TRF1;TTAGGG repeat-binding factor 1
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- Yeast
- Baculovirus
- Non
- His
- GST
- DDK
- Myc
- Avi
- Fc
Involved Pathway
TERF1 involved in several pathways and played different roles in them. We selected most pathways TERF1 participated on our site, such as Cell Cycle,Cellular Senescence,Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with TERF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Damage/Telomere Stress Induced Senescence | TINF2,ASF1A,HIST1H1A,RAD50,H1F0,CABIN1,HIST1H1E,HMGA1B,POT1A,HIRA |
| Meiotic synapsis | SYNE1,SYCE1,SYCP2,ACD,STAG1,POT1A,SYCP1,SUN2,TINF2,TERF2 |
| Meiosis | POT1,DIDO1,TERF2,TERF2IP,PSMC3IP,SUN1,SPO11,TEX15,ACD,SYCE1 |
| Cell cycle | CDKN2B,PKMYT1,RAD21,CDH1-A,TFDP1A,USO1,SYNE1,CDC45,NCAPG2,RUVBL2 |
| Chromosome Maintenance | APITD1,OIP5,RBBP7,CENPP,DNA2,NPM1,ITGB3BP,ACD,CENPQ,POT1 |
| Cellular responses to stress | TERF2IP,CABIN1,CDKN2D,PHC2,H3F3D,HIST4H4,CBX4,CBX6,ST13,MAP1LC3B |
| Packaging Of Telomere Ends | POT1,ACD,TERF2,POT1A,TINF2 |
| Cellular Senescence | CDK6,POT1,HIST1H1C,POT1A,HIRA,KAT5,IGFBP7,EED,HIST1H1E,RAD50 |
Protein Function
TERF1 has several biochemical functions, for example, DNA binding,DNA binding, bending,double-stranded telomeric DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TERF1 itself. We selected most functions TERF1 had, and list some proteins which have the same functions with TERF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | MAFGB,ALX4,EXT1,BMP6,KCNH1,TAS1R3,TLR1,SMC1A,ADD1,BMP7A |
| protein binding | SMAD4,SPTAN1,KAT5,CDK9,TWF2,SIL1,PRMT1,HMGB1,UBQLN1,MMP2 |
| double-stranded telomeric DNA binding | PURA,TERF2,TERFA |
| microtubule binding | KIF18B,DNM2,S100A8,SYBU,VAPA,NDRG1,KIF5B,CNN3,GOLSYN,FNTA |
| DNA binding | TNP2,NUFIP1,LASS4,KDM5A,HMG20A,HIST1H4E,HMGB3A,ZFP36,ZFP35,SCML1 |
| telomeric DNA binding | CTC1,TEN1,TP53BP1,NCL,XRCC5,TERT,POT1A,TERFA,TINF2,HNRNPD |
| protein homodimerization activity | TSC2,TRPM8,SRR,MAP3K10,NR6A1,NR0B2,AIMP1,UGT1A6,PRLR,SLC39A13 |
| DNA binding, bending | HHEX,FOXI1,FOXC1,HMGA2,FOXD1,SRY,CRIP1,FOXD4,HMGB2,LEF1 |
Interacting Protein
TERF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TERF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TERF1.
TINF2;PINX1;MAPRE1;TNKS
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References
- Gilchrist, GC; Kurjanowicz, P; et al. Telomere Length and Telomerase Activity in Bovine Pre-implantation Embryos In Vitro. REPRODUCTION IN DOMESTIC ANIMALS 50:58-67(2015).
- Garrobo, I; Marion, RM; et al. Genome-wide analysis of in vivo TRF1 binding to chromatin restricts its location exclusively to telomeric repeats. CELL CYCLE 13:3742-3749(2014).
