TERF1 Protein, telomeric repeat binding factor (NIMA-interacting) 1


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Official Full Name telomeric repeat binding factor (NIMA-interacting) 1
Background This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]
Synonyms TERF1; telomeric repeat binding factor (NIMA-interacting) 1; TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS; telomeric repeat-binding factor 1; NIMA-interacting protein 2; telomeric protein Pin2/TRF1; TTAGGG repeat-binding factor 1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • His/GST
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TERF1-001H Recombinant Human TERF1 Protein, His-GST-tagged E.coli His/GST
    Human TERF1-002H Recombinant Human TERF1 Protein, His-tagged E.coli His
    Human TERF1-1537H Recombinant Human TERF1 protein E.coli N/A
    Human TERF1-30122TH Recombinant Human TERF1, His-tagged E.coli His
    Human TERF1-505H Recombinant Human TERF1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TERF1-5250H Recombinant Human TERF1 Protein, GST/His-tagged E.coli GST/His
    Human TERF1-528HCL Recombinant Human TERF1 cell lysate Insect Cell N/A
    Human TERF1-875H Recombinant Human TERF1, His tagged Insect Cell His
    Mouse TERF1-16643M Recombinant Mouse TERF1 Protein Mammalian Cell His
    Chicken TERF1-5950C Recombinant Chicken TERF1 Mammalian Cell His

    TERF1 involved in several pathways and played different roles in them. We selected most pathways TERF1 participated on our site, such as Cell Cycle, Cellular Senescence, Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with TERF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell Cycle ZBTB17; CDC26; CHEK2; SETB; TEX12; GADD45AB; MAD2L2; ESCO2; DYNC1I2; SET
    Cellular Senescence HIST1H1B; RBBP7; CBX6A; HIRA; ASF1A; HMGA1-RS1; CDKN2A; IGFBP7; CBX8; AGO1
    Cellular responses to stress RRAGB; DYNLL2A; EEF1A1; PRDX2; CDK6; TXN; HSPH1; HMGA1B; H3F3B.1; CDKN2A
    Chromosome Maintenance APITD1; TINF2; POLD3; MIS18A; CENPH; CENPA; PANE1; SMARCA5; CENPC1; ITGB3BP
    DNA Damage/Telomere Stress Induced Senescence TINF2; TERF2IP; HMGA1B; HIST1H1D; HIST1H1E; HMGA1-RS1; HIRA; POT1A; HIST1H1A; HIST1H1B
    Meiosis TEX15; SUN1; FKBP6; TERF2IP; SYNE1; TEX12; MSH4; TERF1; MSH5; STAG1
    Meiotic synapsis SYNE1; POT1; ACD; SYCE1; DIDO1; POT1A; SYNE2; SYCP2; SUN2; TERF2
    Packaging Of Telomere Ends TERF1; POT1; TINF2; ACD; TERF2; POT1A

    TERF1 has several biochemical functions, for example, DNA binding, DNA binding, bending, double-stranded telomeric DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TERF1 itself. We selected most functions TERF1 had, and list some proteins which have the same functions with TERF1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ZFP687; ZNF526; FLI1A; UBTFL1; TBX2A; NPAS1; CARHSP1; POU3F1; SCXB; ARID3B
    DNA binding, bending TERF1; HMGB2; CRIP1; LEF1; HHEX; HMGA2; HMGB3; FOXC1; TOP2B; FOXI1
    double-stranded telomeric DNA binding PURA; TERF1; TERF2; TERFA
    microtubule binding KIF3C; KIF2B; KATNAL1; SGIP1; ARHGEF2; KIF18A; PSRC1; KIF22; GAS2L1; KIF17
    protein binding KCNH7; STXBP3; PTGIS; C17orf62; PIP5K1B; TSSK2; ITSN2; NIF3L1; WDFY3; IL7R
    protein heterodimerization activity MLXIPL; GABRR1; NOTCH4; SMAD2; SOX4; CASP8; SFRP5; EFHA1; DRAP1; HIST1H4E
    protein homodimerization activity GSTZ1; TRIM37; MBL1; Bcl2a1b; CADM1A; ZHX2; SLC30A8; HOMER2; KIT; BCL2
    telomeric DNA binding SMG6; TERFA; TP53BP1; XRCC5; CTC1; TERT; NCL; CDAN1; HNRNPD; TINF2

    TERF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TERF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TERF1.


    Gilchrist, GC; Kurjanowicz, P; et al. Telomere Length and Telomerase Activity in Bovine Pre-implantation Embryos In Vitro. REPRODUCTION IN DOMESTIC ANIMALS 50:58-67(2015).
    Garrobo, I; Marion, RM; et al. Genome-wide analysis of in vivo TRF1 binding to chromatin restricts its location exclusively to telomeric repeats. CELL CYCLE 13:3742-3749(2014).

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