Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

TET2

Official Full Name

tet methylcytosine dioxygenase 2
Overview

The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.
Synonyms

TET2; tet methylcytosine dioxygenase 2; KIAA1546 , tet oncogene family member 2; methylcytosine dioxygenase TET2; FLJ20032; tet oncogene family member 2; probable methylcytosine dioxygenase TET2; MDS; KIAA1546; MGC125715;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E. coli
E.coli
HEK293
Insect Cell
Mammalian Cell
Sf9 Insect Cell

Tag

FLAG
His
GST
His (Fc)
Avi
His|KSI
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TET2-3184H	Recombinant Human TET2, His-tagged	E. coli	His	1-350 aa	$319 / 25ug
Human	TET2-160H	Recombinant Human TET2, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	TET2-01H	Recombinant Human TET2 Protein, FLAG/His-tagged	Insect Cell	FLAG/His		Inquiry
Human	TET2-311H	Recombinant Human TET2 protein, His-tagged	E. coli	His	1-350 aa	Inquiry
Human	TET2-5947H	Recombinant Human TET2 Protein (Gln1138-Lys1462), N-His tagged	E.coli	N-His	Gln1138-Lys1462	Inquiry
Mouse	TET2-16653M	Recombinant Mouse TET2 Protein	Mammalian Cell	His		Inquiry
Mouse	TET2-9135M	Recombinant Mouse TET2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	TET2-9135M-B	Recombinant Mouse TET2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	TET2-2683M	Recombinant Mouse TET2 Protein (1810-1912 aa), His-KSI-tagged	E.coli	His/KSI	1810-1912 aa	Inquiry
Chicken	TET2-5153C	Recombinant Chicken TET2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TET2 Related Articles
TET2 Related Research Area

TET2 involved in several pathways and played different roles in them. We selected most pathways TET2 participated on our site, such as Epigenetic regulation of gene expression, Gene Expression, TET1,2,3 and TDG demethylate DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with TET2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Epigenetic regulation of gene expression	DNMT3A;EFCAB11;MTF2;SAP130;SMARCA5;DNMT1;EED;SAP30BP;SAP30
Gene Expression	ZNF12;LSM11;GATAD2B;TNKS1BP1;ZNF75A;NFIA;ZNF490;ZNF266;TYW1
TET1,2,3 and TDG demethylate DNA	TET3;TET2;TET1

TET2 has several biochemical functions, for example, DNA binding, ferrous iron binding, methylcytosine dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TET2 itself. We selected most functions TET2 had, and list some proteins which have the same functions with TET2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	TCEB3;MEOX2B;BCLAF1;KCNA3;ENG2B;PPARA;YBX1;PAX2A;MEIOB
ferrous iron binding	ALKBH2;Trf;SNCA;EGLN2;TH;TF;SERPINB1A;ALKBH1;DNAJC24
methylcytosine dioxygenase activity	TET3;TET1;ALKBH1;TET2
protein binding	PIM3;EDA2R;URI1;PRPF4B;UBLCP1;HYLS1;RTP4;ZNF614;C2orf28
zinc ion binding	ADAMTS20;MUL1A;ZFAND2A;LIMS3L;EDEM3;SHANK3;ZDHHC13;SIRT3;LIMS1

TET2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TET2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TET2.

OGT; HCFC1; TBC1D4; brnQ3; YWHAQ; SMARCA4; YWHAG; YWHAH; SMARCC2

Aoki, Y; Watanabe, T; et al. Identification of CD34(+) and CD34(-) leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia. BLOOD 125:967-980(2015).

Ahearne, MJ; Allchin, RL; et al. Follicular helper T-cells: expanding roles in T-cell lymphoma and targets for treatment. BRITISH JOURNAL OF HAEMATOLOGY 166:326-335(2014).

Tumor Suppressors