The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene.
TGIF2 involved in several pathways and played different roles in them. We selected most pathways TGIF2 participated on our site, such as TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGIF2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
TGIF2 has several biochemical functions, for example, DNA binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGIF2 itself. We selected most functions TGIF2 had, and list some proteins which have the same functions with TGIF2. You can find most of the proteins on our site.
Function DNA binding
Related Protein NKX2; HOXC13B; POU6F1; ZNF614; HER9; MSXD; NKX2-6; SOX1; ZNF157; RBM6
Function transcription factor activity, sequence-specific DNA binding
Related Protein RUNX2; FEV; NFIL3-5; T; SCAND3; ZFP161; ZNF274; FOXD4; DMRT2; MYCN