ticam1
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  • Official Full Name
  • toll-like receptor adaptor molecule 1
  • Background
  • Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering
  • Synonyms
  • TICAM1; toll-like receptor adaptor molecule 1; TIR domain-containing adapter molecule 1; MGC35334; PRVTIRB; TICAM 1; TRIF; putative NF-kappa-B-activating protein 502H; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter p
Cat.#:TICAM1-648HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TICAM1 Protein, His-tagged
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Cat.#:Ticam1-649MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ticam1 Protein, His-tagged
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Cat.#:TICAM1-16772MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TICAM1 Protein
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Cat.#:TICAM1-1021CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TICAM1 Protein, His-tagged
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Cat.#:TICAM1-4712RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TICAM1 Protein, His-tagged
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Cat.#:TICAM1-3657CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TICAM1
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Cat.#:TICAM1-3910ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TICAM1
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Cat.#:TICAM1-1080HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TICAM1 293 Cell Lysate
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Involved Pathway

TICAM1 involved in several pathways and played different roles in them. We selected most pathways TICAM1 participated on our site, such as Activated TLR4 signalling, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TICAM1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activated TLR4 signalling
TLR6; CREB1; DHX9; DUSP3B; MAPKAPK2B; SAA1; MAP3K8; CREB1B; TICAM1; DUSP3
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
TICAM1; TANK
Apoptosis
CASP8; YWHAQ; IL1RAP; PPP3CB; MYD88; PRKAR2A; PIK3CA; IRAK3; HIST1H1B; AKT2
Caspase activation via extrinsic apoptotic signalig pathway
DAPK1; CASP8L1; DAPK3; DCC; RNF8; TICAM1
Chagas disease (American trypanosomiasis)
IRAK4; TRAF6; IFNGR1; AKT2; TGFB1; PPP2R2C; TGFB3; IRAK1; PLCB1; GNA15
Cytosolic sensors of pathogen-associated DNA
POLR3H; AGER; NLRP4B; CRCP; MB21D1; APPB; IFI16; POLR3GLA; DDX41; S100B
Disease
SFTPC; LRRFIP1; AP2A1; TIRAP; KPNA5; VPS37A; NMT2; FDXR; AP2B1; KERA
Diseases associated with the TLR signaling cascade
TLR6; TIRAP; TICAM1; TLR10

Protein Function

TICAM1 has several biochemical functions, for example, protein binding, protein kinase binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TICAM1 itself. We selected most functions TICAM1 had, and list some proteins which have the same functions with TICAM1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein HOXA9; RBM4; CCDC103; GRB7; SEMA4C; ATP2A2; NPM2; UQCRB; DPM3; AMPH
Function protein kinase binding
Related Protein GSK3B; SPDYB; HNRNPA0; PPP1CC; GRIN2A; PPP1R12B; MS4A2; NME2; CSPG4; TBC1D14
Function signal transducer activity
Related Protein PLCB1; ITGB3BP; TAAR13C; ACKR3B; SH2B2; OLFR476; TAAR13B; TNK1; TAS2R109; VMN1R52

Interacting Protein

TICAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TICAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TICAM1.
TBK1; TNFAIP3; TICAM2; PIAS4; SRSF4; KIF21B; Immt; TANK; CDCA5; CEP170P1; MKNK2