tlr3
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  • Official Full Name
  • toll-like receptor 3
  • Background
  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TLR3; toll-like receptor 3; CD283; IIAE2;
Cat.#:TLR3-975HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Toll-like Receptor 3
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Cat.#:TLR3-2071HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR3 protein, His & S-tagged
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Cat.#:TLR3-25HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human TLR3 protein, His-tagged
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Cat.#:TLR3-30112THTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TLR3 protein
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Cat.#:Tlr3-2072MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tlr3 protein, His-tagged
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Cat.#:Tlr3-2073MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tlr3 protein, His & GST-tagged
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Cat.#:Tlr3-3079MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Tlr3, His tagged
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Cat.#:Tlr3-3277MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tlr3, His tagged
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Cat.#:Tlr3-2074RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tlr3 protein, His & GST-tagged
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Cat.#:TLR3-1670RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR3 Protein
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Cat.#:TLR3-1671RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR3 Protein, hIgG1-tagged
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Cat.#:TLR3-1672RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR3 Protein, hIgG4-tagged
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Cat.#:TLR3-4732RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TLR3 Protein, His-tagged
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Cat.#:TLR3-1883CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TLR3
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Cat.#:TLR3-2076ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TLR3
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Cat.#:TLR3-2447MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TLR3 cell lysate
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Cat.#:TLR3-642MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse TLR3 cell lysate
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Involved Pathway

Tlr3 involved in several pathways and played different roles in them. We selected most pathways Tlr3 participated on our site, such as Toll-like receptor signaling pathway, Hepatitis C, Hepatitis B, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tlr3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Toll-like receptor signaling pathway
IKBKE; MAPK8; MAP2K7; IFNA17; IFNB; AKT2L; IFNA10; IFNA21; IL8L2; PIK3R2
Hepatitis C
Ifna15; CLDN11; CLDN5; PIK3CB; IFNA4; PIK3R2; PPP2R2B; AKT1; CLDN14; IFNA10
Hepatitis B
MMP9; BCL2; PIK3R5; CXCL8; OSTN; PTEN; SMAD3; FOS; Casp3; DDX3X
Influenza A
IL12B; IFNGR2; RAE1; PRKCA; OAS1; IFNA10; PABPN1; HSPA1B; IKBKB; NXF2
Herpes simplex infection
HMGN1; C3; RNASEL; IKBKE; UBE2R2; TNFRSF14; HCFC1B; GTF2I; Casp3; IFNA5

Protein Function

Tlr3 has several biochemical functions, for example, double-stranded RNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tlr3 itself. We selected most functions Tlr3 had, and list some proteins which have the same functions with Tlr3. You can find most of the proteins on our site.
Function
Related Protein
Function double-stranded RNA binding
Related Protein ZFP346; OAS2; DHX36; VIM; DDX21; DHX58; OAS1; OAS1A; BARHL1; IFIH1
Function identical protein binding
Related Protein SID4; PFKM; MNS1; CHEK2; ALDH4A1; ITGA2B; PRKD1; S100A1; DVL1; CCDC91
Function protein binding
Related Protein REL; SOX-2; IL12A; PLEC; THRB; SNAPC5; C1QB; FCER2; LRP2; AP2M1
Function receptor activity
Related Protein KLRG1; PAQR9; SLC20A1; ANPEP; NLGN3; TREM2; FPR1; CXCR3; VMN1R41; NR2C1
Function transmembrane signaling receptor activity
Related Protein EGFR; LAG3; OR4D2; OR4F29; M6PR; OR4C12; EDAR; GLP1R; TNFRSF8; ADCYAP1R1A

Interacting Protein

Tlr3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tlr3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tlr3.
PIK3R1; MBL2; SRC; TRIL; CHEK2; TRAF3; TOLLIP

Tlr3 Related Articles

Xu, SY; Zhao, YF; et al. Threonine and tryptophan supplementation enhance porcine respiratory and reproductive syndrome (PRRS) vaccine-induced immune responses of growing pigs. ANIMAL SCIENCE JOURNAL 86:294-304(2015).
Sakuma, C; Sato, M; et al. Anti-WASP intrabodies inhibit inflammatory responses induced by Toll-like receptors 3, 7, and 9, in macrophages. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 458:28-33(2015).