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Tlr3

  • Official Full Name

    toll-like receptor 3

  • Overview

    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    TLR3; toll-like receptor 3; CD283; IIAE2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • E.coli
  • HEK293
  • Human Cell
  • Human Cells
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Fc
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TLR3-25H Active Recombinant Human TLR3 protein, His-tagged Mammalian cells His Lys27-Ser711
Human TLR3-30112TH Active Recombinant Human TLR3 protein HEK293 N/A
Human TLR3-2071H Recombinant Human TLR3 protein, His & S-tagged E.coli His/S Leu404~Leu532 (Accession # O15455)
Human TLR3-975H Recombinant Human Toll-like Receptor 3 HEK293 N/A
Human TLR3-0266H Recombinant Human TLR3 protein, His-tagged Insect Cells His Lys27-Ser711
Human TLR3-4191H-B Recombinant Human TLR3 Protein Pre-coupled Magnetic Beads HEK293
Human TLR3-151H Recombinant Human TLR3 Protein, His-tagged Human Cells His
Human TLR3-2162H Recombinant Human TLR3 protein, Fc-tagged HEK293 Fc Ser 23 - Glu 703
Human TLR3-5137H Recombinant Human TLR3 Protein (Met1-Leu704), C-His tagged Mammalian cells C-His Met1-Leu704
Human TLR3-3192H Recombinant Human TLR3 Protein (Lys27-Ser711), His tagged E.coli His Lys27-Ser711
Human TLR3-071H Recombinant Human TLR3 Protein(26-348 aa), His-tagged E.coli His 26-348 aa
Human TLR3-4191H Recombinant Human TLR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tlr3-3079M Recombinant Mouse Tlr3, His tagged Insect Cell His
Mouse Tlr3-3277M Recombinant Mouse Tlr3 protein, His-tagged HEK293 His Met1-Leu705
Mouse Tlr3-2072M Recombinant Mouse Tlr3 protein, His-tagged E.coli His Leu533~Leu705 (Accession # Q99MB1)
Mouse Tlr3-2073M Recombinant Mouse Tlr3 protein, His & GST-tagged E.coli His/GST Glu727~His905
Mouse TLR3-642MCL Recombinant Mouse TLR3 cell lysate Insect Cell N/A
Mouse TLR3-2447MCL Recombinant Mouse TLR3 cell lysate Human Cell N/A
Mouse TLR3-0788M Recombinant Mouse TLR3 protein, Fc-tagged HEK293 Fc Thr26-Leu705
Rat Tlr3-2074R Recombinant Rat Tlr3 protein, His & GST-tagged E.coli His/GST Ser381~Asp699 (Accession # F1LN63)
Rhesus monkey TLR3-1670R Recombinant Rhesus Monkey TLR3 Protein HEK293 N/A
Rhesus monkey TLR3-1672R Recombinant Rhesus Monkey TLR3 Protein, hIgG4-tagged HEK293 hIgG4
Rhesus monkey TLR3-1671R Recombinant Rhesus Monkey TLR3 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus Macaque TLR3-4732R Recombinant Rhesus monkey TLR3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TLR3-4546R-B Recombinant Rhesus Macaque TLR3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TLR3-4546R Recombinant Rhesus Macaque TLR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish TLR3-2076Z Recombinant Zebrafish TLR3 Mammalian Cell His
Chicken TLR3-1883C Recombinant Chicken TLR3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Tlr3 Related Articles
  • Tlr3 Related Research Area

Tlr3 involved in several pathways and played different roles in them. We selected most pathways Tlr3 participated on our site, such as Toll-like receptor signaling pathway, Hepatitis C, Hepatitis B, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tlr3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Toll-like receptor signaling pathwayMAP2K4B;FADD;MAPK13;MAPK3;IFNA14;IL12A;PIK3R1;IRF7;IFNA17
Hepatitis CAKT2;PPP2CA;MAPK10;NFKBIA;PIK3CG;CLDN22;IRF9;CLDN11;PPP2R2C
Hepatitis BTLR3;CXCL8;PRKCA;MAP2K1;TRP53;Ifna15;HBXIP;YWHAZ;APAF1
Influenza ADDX58;GSK3B;IFNA16;PLG;PABPN1L;NXF3;TMPRSS13;KPNA2;MAP2K7
Herpes simplex infectionPOU2F3;TRP53;FOS;IFNG1-2;IL15;HLA-DPA1;MAP3K7;PER1B;MAVS

Tlr3 has several biochemical functions, for example, double-stranded RNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tlr3 itself. We selected most functions Tlr3 had, and list some proteins which have the same functions with Tlr3. You can find most of the proteins on our site.

Function Related Protein
double-stranded RNA bindingEIF4A1;ACTN1;ILF2;DDX58;OAS1B;HMGB1;HSPD1;OAS3;ZNF346
identical protein bindingCOL1A1;LTBR;DVL2;SQSTM1;COL1A2;SERPINB1A;RIPK1;MCPH1;SERPINA1D
protein bindingSTAR;MATK;ADAP2;ASNS;VPS16;WBP2;LGALS14;KLF2;TSSK3
receptor activityCNTNAP1;EXTL3;FKBP3;IL18R1;Tnfrsf22;SEMA4D;KLRB1F;CD1D;MED4
transmembrane signaling receptor activitySLAMF1;OR12D3;KLRB1;TNFRSF10D;FZD1;GLP1R;CD300C;P2RX6;GP1BB

Tlr3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tlr3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tlr3.

PIK3R1; MBL2; SRC; TRIL; CHEK2; TRAF3; TOLLIP

Xu, SY; Zhao, YF; et al. Threonine and tryptophan supplementation enhance porcine respiratory and reproductive syndrome (PRRS) vaccine-induced immune responses of growing pigs. ANIMAL SCIENCE JOURNAL 86:294-304(2015).
Sakuma, C; Sato, M; et al. Anti-WASP intrabodies inhibit inflammatory responses induced by Toll-like receptors 3, 7, and 9, in macrophages. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 458:28-33(2015).
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