TNNT3 Protein, troponin T type 3 (skeletal, fast)


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Official Full Name troponin T type 3 (skeletal, fast)
Background The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B).
Synonyms TNNT3; troponin T type 3 (skeletal, fast); troponin T3, skeletal, fast; troponin T, fast skeletal muscle; AMCD2B; DA2B; DKFZp779M2348; FSSV; troponin T3; skeletal; fast; fast skeletal muscle; Beta TnTF; Beta-TnTF; Fast skeletal muscle troponin T; fTnT; TNNT 3; TNNT3_HUMAN; TnTf; Troponin T; Troponin T fast skeletal muscle; Troponin T type 3 (skeletal fast); Troponin T type 3; Troponin T3 skeletal fast; OTTHUMP00000014432; OTTHUMP00000014433; OTTHUMP00000014434; OTTHUMP00000014435; OTTHUMP00000014437; OTTHUMP00000014438; OTTHUMP00000069617; OTTHUMP00000069618; OTTHUMP00000069619; OTTHUMP00000194823; OTTHUMP
    • Species :
    • Bovine
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Bovine TNNT3-2657B Recombinant Bovine TNNT3 Protein (2-271 aa), His-Myc-tagged E.coli His/Myc
    Bovine TNNT3-2780B Recombinant Bovine TNNT3 Protein (2-271 aa), His-Myc-tagged Insect Cell His/Myc
    Human TNNT3-7953H Recombinant Human TNNT3 protein, His-tagged E.coli His
    Human TNNT3-878HCL Recombinant Human TNNT3 293 Cell Lysate HEK293 N/A
    Mouse TNNT3-17200M Recombinant Mouse TNNT3 Protein Mammalian Cell His
    Rat TNNT3-6212R Recombinant Rat TNNT3 Protein Mammalian Cell His
    Chicken TNNT3-6484C Recombinant Chicken TNNT3 Mammalian Cell His

    TNNT3 involved in several pathways and played different roles in them. We selected most pathways TNNT3 participated on our site, such as Muscle contraction, Striated Muscle Contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Muscle contraction TNNI2B.2; TMOD4; TNNI2A.4; TNNI2A.3; MYBPC1; SORBS3; MYL6B; ANXA6; TMOD3; TNNI2
    Striated Muscle Contraction TNNT1; TNNI2B.1; TCAP; MYL1; DESMA; DES; MYBPC2; TNNI1; TMOD1; VIML

    TNNT3 has several biochemical functions, for example, contributes_to actin binding, contributes_to calcium-dependent ATPase activity, calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNNT3 itself. We selected most functions TNNT3 had, and list some proteins which have the same functions with TNNT3. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to actin binding TNNT3; TNNC2; TNNI2
    contributes_to calcium-dependent ATPase activity TNNT3
    calcium-dependent protein binding CALM3; KCNIP3; TNNI3; SYT1; C9orf9; SELP; S100PBP; VLDLR; S100B; TNNC1
    contributes_to tropomyosin binding TNNT3
    tropomyosin binding TNNT3; TNNT1; LMOD1; TNNT2A; PYCARD; LMOD3; CALD1; S100A6; LMOD2A; NEBL
    troponin C binding TNNT3; TNNI3
    troponin I binding TNNT3; RCAN3; TNNI3K; TNNC1

    TNNT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNT3.


    Lindstrom, S; Thompson, DJ; et al. Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. NATURE COMMUNICATIONS 5:-(2014).
    Dudakovic, A; Camilleri, E; et al. High-Resolution Molecular Validation of Self-Renewal and Spontaneous Differentiation in Clinical-Grade Adipose-Tissue Derived Human Mesenchymal Stem Cells. JOURNAL OF CELLULAR BIOCHEMISTRY 115:1816-1828(2014).

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