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  • Official Full Name
  • topoisomerase (DNA) I
  • Background
  • This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
  • Synonyms
  • TOP1; topoisomerase (DNA) I; TOPI; DNA topoisomerase 1; OTTHUMP00000031713; DNA topoisomerase I; type I DNA topoisomerase
Cat.#:TOP1-1533HTag:
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human TOP1 Protein
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Cat.#:TOP1-445HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TOP1 Protein, His-tagged
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Cat.#:TOP1-01HTag:hexa-His
Source (Host):Insects cellSpecies:Human
Product nameRecombinant Human TOP1 Protein, hexa-His-tagged
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Cat.#:TOP1-1196HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Topoisomerase (DNA) I, C-terminal Domain
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Cat.#:TOP1-1197HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Topoisomerase (DNA) I, N-terminal Domain
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Cat.#:TOP1-30911THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TOP1, His-tagged
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Cat.#:TOP1-30912THTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TOP1, His-tagged
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Cat.#:TOP1-31198THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TOP1, His-tagged
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Cat.#:TOP1-31538THTag:
Source (Host):Species:Human
Product nameRecombinant Human TOP1
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Cat.#:TOP1-351HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human TOP1 protein, His-tagged
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Cat.#:TOP1-3745HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TOP1, His-tagged
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Cat.#:TOP1-519HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Topoisomerase (DNA) I
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Cat.#:TOP1-8479HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human TOP1, His-tagged
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Cat.#:TOP1-17228MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TOP1 Protein
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Cat.#:TOP1-6223RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TOP1 Protein
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Cat.#:TOP1-4899RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TOP1 Protein, His-tagged
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Cat.#:TOP1-6667CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TOP1
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Cat.#:TOP1-1194HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Topoisomerase (DNA) I
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Cat.#:TOP1-1195HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Topoisomerase (DNA) I, Core Domain
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Cat.#:TOP1-867HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TOP1 293 Cell Lysate
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Involved Pathway

TOP1 involved in several pathways and played different roles in them. We selected most pathways TOP1 participated on our site, such as Caspase cascade in apoptosis, Integrated Pancreatic Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Caspase cascade in apoptosis
ACTA1; CASP2; CRADD; SATB1; DFFA; GAS2; CASP4; TOP1; TFAP2A; DIABLO
Integrated Pancreatic Cancer Pathway
JUND; CST3; CASP12; BRF1; FKBP3; MST1; RB1CC1; MAPK4; FST; PPP1R13L

Protein Function

TOP1 has several biochemical functions, for example, DNA binding, DNA topoisomerase type I activity, DNA topoisomerase type II (ATP-hydrolyzing) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOP1 itself. We selected most functions TOP1 had, and list some proteins which have the same functions with TOP1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein HIST1H2BD; ZZZ3; PIAS4; PCGF6; OVOL2; GATA1; HEMK1; CHD2; ZNF280C; FOXO3
Function DNA topoisomerase type I activity
Related Protein TOP1MT; TOP1; TOP3A; TOP3B; CDK5R2; TOP1L
Function DNA topoisomerase type II (ATP-hydrolyzing) activity
Related Protein TOP1; TOP2B; TOP1L; TOP1MT; TOP2A
Function chromatin binding
Related Protein PPARG; TCF7L1B; SMARCE1; SSRP1; RERE; TDRD3; RAN; NCAPD2; POU4F2; TCF7L1A
Function core promoter sequence-specific DNA binding
Related Protein TP53; NRF1; ZFP932; THRAP3; REST; RORA; ZFP750; SOHLH1; NRIP1; KLF10
Function poly(A) RNA binding
Related Protein DDX52; ALKBH5; R3HDM2; CSTF2; MRPL3; YBX1; IGF2BP3; UTP15; PRPF3; RPL37A
Function protein binding
Related Protein COA6; SNAP47; CDKN1A; SLC6A12; TRIM5; STX3; MAP4K3; MSH5; NAA50; RBKS

Interacting Protein

TOP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TOP1.
lt_sv40; NKX3-1; ABL1

TOP1 Related Articles

Honjo, T; Kobayashi, M; et al. The AID Dilemma: Infection, or Cancer?. ADVANCES IN CANCER RESEARCH, VOL 113 113:1-44(2012).
Nagaoka, H; Tran, TH; et al. Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity. INTERNATIONAL IMMUNOLOGY 22:227-235(2010).