top2b
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  • Official Full Name
  • topoisomerase (DNA) II beta 180kDa
  • Background
  • This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance.
  • Synonyms
  • TOP2B; topoisomerase (DNA) II beta 180kDa; topoisomerase (DNA) II beta (180kD); DNA topoisomerase 2-beta; topo II beta; antigen MLAA-44; topoisomerase IIb; topoisomerase II beta; U937 associated antigen; DNA topoisomerase II beta; DNA topoisomerase II, 18
Cat.#:TOP2B-01HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Type II Topoisomerase, His-tagged
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Cat.#:TOP2B-105HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TOP2B
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Cat.#:TOP2B-19HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TOP2B, His-tagged
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Cat.#:TOP2B-6942HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TOP2B protein, GST-tagged
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Cat.#:TOP2B-73HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Topoisomerase (DNA) II Beta 180kDa
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Cat.#:TOP2B-17231MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TOP2B Protein
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Cat.#:Top2b-8246MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Top2b protein, His & T7-tagged
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Cat.#:TOP2B-4900RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TOP2B Protein, His-tagged
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Cat.#:TOP2B-6639CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TOP2B
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Cat.#:TOP2B-4217ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TOP2B
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Protein Function

TOP2B has several biochemical functions, for example, ATP binding, DNA binding, bending, DNA topoisomerase type II (ATP-hydrolyzing) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOP2B itself. We selected most functions TOP2B had, and list some proteins which have the same functions with TOP2B. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PDIK1L; NUBP1; JAK3; TOR1L1; PEBP1; SIK2; NADK2; NME2B.1; XRCC3; NMRK1
Function DNA binding, bending
Related Protein FOXD4; TFAM; TOP2B; SRY; FOXL1; LEF1; HMGB3; HHEX; FOXI1; HMGA2
Function DNA topoisomerase type II (ATP-hydrolyzing) activity
Related Protein TOP1L; TOP2B; TOP2A; TOP1; TOP1MT
Function chromatin binding
Related Protein UBE2T; TADA2B; MLH3; MEIS3; SUZ12; FLI1; SMARCD3; PAX3; HOXD13; POU4F2
Function enzyme binding
Related Protein RAD9A; VAPB; MAPT; KRT79; KAT8; CDC20; SORT1; UGT1A1; KDM4C; TSPAN17
Function histone deacetylase binding
Related Protein NUDT21; MYOCD; YY1; HES1; PARK2; KPNA2; ZFP932; RAD9; HIC1; TOP2A
Function metal ion binding
Related Protein NEURL1AA; SLC2A4RG; BTR30; ARIH1L; CHN2; ARID2; ZNF521; PKM; ZFP12; AGFG1
Function protein C-terminus binding
Related Protein RBFOX1; ATXN2; HIC2; KCNJ11; CTGF; PPP1R9B; PPM1A; VPS4B; HSPB7; NCF2
Function protein heterodimerization activity
Related Protein BIK; JAM2; BMP6; TFAP2B; PVALB; H3F3A; MID2; HGF; ABTB2; KATNA1
Function protein kinase C binding
Related Protein SDPRB; PKP2; GNB2L1; PEA15A; PLEK; TIRAP; YWHAG; TOP2A; TOP2B; C1QBP

Interacting Protein

TOP2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOP2B here. Most of them are supplied by our site. Hope this information will be useful for your research of TOP2B.
USF1; ESR1; Top2b; fas_human_gene; PRKCD; UVRAG