tp73
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  • Official Full Name
  • tumor protein p73
  • Background
  • The p73 gene has been mapped to the short arm of chromosome 1, position 1p36, a region frequently deleted in neuroblastomas. Allelic loss at 1p36 has also been reported in melanoma, breast carcinoma and colon carcinoma. The p73 transcript is differentially spliced to generate 2 mRNAs that code for the 2 isoforms of p73, p73alpha and p73beta. There is significant sequence homology between amino acid residues in the p73 isoforms and the DNA-binding, transactivation and oligomerization domains of p53. p73 activates p21WAF1 in transfected SK-N-AS cells and transfected SAOS2 cells, suggesting a role for p73 as a transcription factor. In similar transfection experiments, p73 was reported to induce apoptosis in SAOS2 and BHK cells.
  • Synonyms
  • TP73; tumor protein p73; P73; p53-related protein; p53-like transcription factor
Cat.#:TP73-30454THTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TP73
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Cat.#:TP73-30577THTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TP73
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Cat.#:TP73-30579THTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TP73
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Cat.#:TP73-9700ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TP73
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Cat.#:TP73-328HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Tumor Protein P73, GST-tagged
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Cat.#:TP73-329HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Tumor Protein P73, GST-tagged
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Cat.#:TP73-330HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Tumor Protein P73, GST-tagged
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Cat.#:TP73-853HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TP73 293 Cell Lysate
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Involved Pathway

TP73 involved in several pathways and played different roles in them. We selected most pathways TP73 participated on our site, such as p signaling pathway, Hippo signaling pathway, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP73 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
p signaling pathway
CASP9; CCND1; FAS; CYCSB; CCND2; MDM4; SIAH1A; BBC3; IGF1; PMAIP1
Hippo signaling pathway
LIMD1; GDF5; PPP1CB; FGF1; SOX2; DVL3; NKD1; GDF6; MOB1A; TGFBR2
Neurotrophin signaling pathway
CAMK2A; PIK3R5; CDC42; Fasl; ARHGDIA; MAP2K1; IRAK2; CALML3; IRAK4; PRKCD
Measles
IFNGR1; IFNGR2; CD209B; NFKBIB; IL13; CD209; IL2RG; TRAF6; RELA; CD28

Protein Function

TP73 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP73 itself. We selected most functions TP73 had, and list some proteins which have the same functions with TP73. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein MLXIPL; NEUROG3; MYC; KCNA3; SNAI3; HNRNPK; TBX3; TCF12; ASCL1; HIST2H3A
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein NPAS4A; ZNF488; ERF; FOXC1; SIM1B; SOX8; TRP53; SOX21A; AHR2; FOXS1
Function chromatin binding
Related Protein NCOA5; ZGLP1; NCOA2; JMJD5; EWSR1A; ERG; NOC2L; NR5A1; ATXN7; SMARCA2
Function damaged DNA binding
Related Protein POLK; GTF2H3; RAD23B; XPC; EP300; REV1; RPS3; BRCA1; TRP53; PNKP
Function double-stranded DNA binding
Related Protein DDX11; TDP1; LSM14A; CRY1; NTHL1; HMGB1; MTERF; GATA1A; MRE11A; MTERFD2
Function identical protein binding
Related Protein COL1A1; ALK; CLDN7; VPS41; CLDN16; MAP3K11; UHRF1; LZTFL1; ACADM; CEP170L
Function metal ion binding
Related Protein TDP2B; TRIM12A; ZNF180; ZNF426; PAPD7; ZNF777; ARMC1; NOB1; CYP2P10; PIKFYVE
Function p53 binding
Related Protein CDKN2AIP; TAF3; ZNF385C; ZMAT4; BLM; RNF34; MSX1; BANP; ZNF385D; MAPKAPK5
Function protein binding
Related Protein PTPN22; MARCH5; CTF1; S100A8; NOXA1; CMTM2A; HDAC7; FRS2; KCNIP1; KIAA0408
Function protein kinase binding
Related Protein CSPG4; MEF2A; PTPRK; MAP2K7; PPME1; PARP1; MAP2K6; PGAM1; CD36; TELO2
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZC3H8; HES1; SOX5; MYC; ATF6B; ZNF174; ETV1; FOXG1C; CHES1; TEAD2
Function transcription factor binding
Related Protein SIX2; RB1; HDAC9; HES6; HOXA7; AHR; PARP1; PSMD10; ETS1; ID1
Function transcription regulatory region DNA binding
Related Protein KLF1; NR5A2; HIVEP3; CCNT1; TFEB; SMARCA2; MESP1; DLX5; PAX2; SP1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein HNRNPK; NRL; JUN; PLAG1; FOXC2; NKX2-8; PITX1; SIX2; FLI1; NFKB2

Interacting Protein

TP73 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP73 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP73.
HSPA9; AURKA

TP73 Related Articles

Santoni, M; Amantini, C; et al. Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells. BRITISH JOURNAL OF CANCER 109:1040-1050(2013).
Casabonne, D; Reina, O; et al. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 96:323-327(2011).