Description : |
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. |
Protein length : |
636 amino acids |
Molecular Weight : |
110.000kDa inclusive of tags |
Source : |
Baculovirus |
Tissue specificity : |
Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue. |
Form : |
Liquid |
Purity : |
>90% by SDS-PAGE |
Storage buffer : |
Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : |
MAQSTATSPDGGTTFEHLWSSLEPD STYFDLPQSSRGNNEVVGGTDSSMD VFHLEGMTTSVMAQFNLLSSTMDQM SSRAASASPYTPEHAASVPTHSPYA QPSSTFDTMSPAPVIPSNTDYPGPH HFEVTFQQSSTAKSATWTYSPLLKK LYCQIAKTCPIQIKVSTPPPPGTAI RAMPVYKKAEHVTDVVKRCPNHELG RDFNEGQSAPASHLIRVEGNNLSQY VDDPVTGRQSVVVPYEPPQVGTEFT TILYNFMCNSSCVGGMNRRPILIII TLEMRDGQVLGRRSFEGRICACPGR DRKADEDHYREQQALNESSAKNGAA SKRAFKQSPPAVPALGAGVKKRRHG DEDTYYLQVRGRENFEILMKLKESL ELMELVPQPLVDSYRQQQQLLQRPS HLQPPSYGPVLSPMNKVHGGMNKLP SVNQLVGQPPPHSSAATPNLGPVGP GMLNNHGHAVPANGEMSSSHSAQSM VSGSHCTPPPPYHADPSLVSFLTGL GCPNCIEYFTSQGLQSIYHLQNLTI EDLGALKIPEQYRMTIWRGLQDLKQ GHDYSTAQQLLRSSNAATISIGGSG ELQRQRVMEAVHFRVRHTITIPNRG GPGGGPDEWADFGFDLPDCKARKQP IKEEFTEAEIH |
Sequence Similarities : |
Belongs to the p53 family.Contains 1 SAM (sterile alpha motif) domain. |