trib3
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  • Official Full Name
  • tribbles pseudokinase 3
  • Background
  • The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TRIB3; tribbles pseudokinase 3; NIPK; SINK; TRB3; SKIP3; C20orf97; tribbles homolog 3; TRB-3; p65-interacting inhibitor of NF-kappaB; p65-interacting inhibitor of NF-kappa-B; neuronal cell death inducible putative kinase; neuronal cell death-inducible putative kinase;
Cat.#:TRIB3-25HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TRIB3, GST-tagged
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Cat.#:TRIB3-30123THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TRIB3
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Cat.#:TRIB3-3073HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TRIB3, GST tagged
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Cat.#:TRIB3-6268RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TRIB3 Protein
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Cat.#:TRIB3-12130ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRIB3
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Cat.#:TRIB3-657HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TRIB3 cell lysate
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Involved Pathway

TRIB3 involved in several pathways and played different roles in them. We selected most pathways TRIB3 participated on our site, such as Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Insulin resistance
PRKAB1; MAPK8A; SLC27A5; PIK3CG; G6PC; GFPT1; FOXO1B; SLC27A1A; PTPN11A; PIK3R3

Protein Function

TRIB3 has several biochemical functions, for example, ATP binding, NOT kinase activity, mitogen-activated protein kinase kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIB3 itself. We selected most functions TRIB3 had, and list some proteins which have the same functions with TRIB3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SMC4; IGF1RA; PAK2B; PRKDC; MAP4K6; CHKB; PIK3CG; ABCF1; RFC5; ABCG2B
Function NOT kinase activity
Related Protein TRIB3; SCYL3
Function mitogen-activated protein kinase kinase binding
Related Protein PIN1; IGBP1; MAP3K11; BRAF; KSR1; TRIB1; RAF1; ARRB1; ACE; TRIB2
Function protein binding
Related Protein AMDHD2; TAS2R16; MPHOSPH6; EEF1A1; SYNM; UBE2Q1; CKM; FPR1; OBSCN; MAB21L3
Function protein kinase binding
Related Protein HDAC7; ATG13; ADAM10; PTPRK; SPDYE2; TMEM173; DNAJA3; MAPK6; CEP68; GHR
Function protein kinase inhibitor activity
Related Protein TRIB1; JIP1; GMFB; MBIP; SH3BP5; CHP1; NPM1; NCK1; PRKRIP1; SOCS1B
Function transcription corepressor activity
Related Protein TAF9B; ZHX3; SKOR1B; AEBP1; PFDN5; JUB; HOXC6; SF1; MAP3K10; HOMEZA
Function ubiquitin protein ligase binding
Related Protein PARK2; BID; HSPA1A; ACTG1; RALB; DIO2; PIAS1; BAG4; WASH; UBE2NA
Function ubiquitin-protein transferase regulator activity
Related Protein TRIB2; TRIB3; TRIB1

Interacting Protein

TRIB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIB3.
ATF4; ATF4; RPGRIP1; PRMT5; MAP2K7; MAP2K1; GDF9; EEF1G; SETDB1; RBM48

TRIB3 Related Articles

Locatelli, SL; Giacomini, A; et al. Perifosine and sorafenib combination induces mitochondrial cell death and antitumor effects in NOD/SCID mice with Hodgkin lymphoma cell line xenografts. LEUKEMIA 27:1677-1687(2013).
Wennemers, M; Stegeman, H; et al. Hypoxia regulation of phosphokinases and the prognostic value of pAKT in breast cancer. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS 28:151-160(2013).