trim28
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  • Official Full Name
  • tripartite motif containing 28
  • Background
  • The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
  • Synonyms
  • TRIM28; tripartite motif containing 28; transcription intermediary factor 1-beta; KAP1; RNF96; TF1B; TIF1B; KAP-1; KRIP-1; TIF1-beta; RING finger protein 96; KRAB-associated protein 1; nuclear corepressor KAP-1; KRAB-interacting protein 1; E3 SUMO-protein
Cat.#:TRIM28-2658HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TRIM28 Protein, MYC/DDK-tagged
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Cat.#:TRIM28-225HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRIM28 Protein, GST-tagged
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Cat.#:TRIM28-226HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRIM28 Protein, His-tagged
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Cat.#:TRIM28-2325HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRIM28, His-tagged
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Cat.#:TRIM28-82HTag:His|Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRIM28, His&FLAG-tagged
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Cat.#:Trim28-1697MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Trim28 protein, His & T7-tagged
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Cat.#:TRIM28-6275RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TRIM28 Protein
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Cat.#:TRIM28-1825HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TRIM28 cell lysate
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Involved Pathway

TRIM28 involved in several pathways and played different roles in them. We selected most pathways TRIM28 participated on our site, such as C-MYB transcription factor network, Corticotropin-releasing hormone, E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
C-MYB transcription factor network
SKI; MYB; LECT2; CEBPB; CSF1R; COL1A2; PPID; TOM1; CLTA; ADA
Corticotropin-releasing hormone
TFAP2A; CYP11B1; CRHBP; CRHR2; CASP12; CYP21A2; KRT1; ADRBK2; JUND; CRHR1
E2F transcription factor network
HIC1; TRIM28; YY1; SMARCA2; CES5A; RBBP8; PRMT5; HBP1; DHFR; E2F4
Gene Expression
NR2C2; ZFP36L1; MED25; MTA2; ZNF543; AARS; NRBF2B; AGO3B; POP4; BAZ2A
Generic Transcription Pathway
PRDX2; ZIM2; GPR19; MED31; ZNF311; ZNF302; ZNF713; MED6; ZNF692; MED23
p53 pathway
E4F1; RASSF1; KAT8; NEDD8; CSNK1G3; SMYD2; HUWE1; PPP1R13L; FBXO11; TRIM28

Protein Function

TRIM28 has several biochemical functions, for example, DNA binding, Krueppel-associated box domain binding, RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM28 itself. We selected most functions TRIM28 had, and list some proteins which have the same functions with TRIM28. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein NKX3.3; E2F7; ARX; ZNF559-ZNF177; ELF2A; Arid4b; CHES1; ZNF12; MIER3; ZNF74
Function Krueppel-associated box domain binding
Related Protein TRIM28
Function RNA polymerase II transcription coactivator activity
Related Protein NCOA1; SOX4; SMARCA4; PHF17; TFAP2B; TRIM28; POU1F1; MED12; MED12L; NEUROD1
Function chromo shadow domain binding
Related Protein LBR; SP100; ATRX; TRIM28; NIPBL; CHAF1A
Function ligase activity
Related Protein RNF125; RNF216; MKRN1; PELI1; ITCHA; RNF212; MID1; TRIM23; TTLL13; MYLIP
Function poly(A) RNA binding
Related Protein TRMT1L; IFI203; GRWD1; DHX34; ALDOA; RRP12; RP9; UTP23; EIF4ENIF1; MRPL37
Function protein binding
Related Protein BOLL; RNF115; GBP5; OSTA; WTIP; MYB; ICAM4; PCBD1; ZCCHC7; SLC1A2
Function protein kinase activity
Related Protein STK25B; PDK2; PRKD2; PANK1A; MAP2K5; SBK3; RIPK3; PKN1; PIK3C3; TGFBR1A
Function contributes_to sequence-specific DNA binding
Related Protein FIGLA; ARNT; TCF3; HNRNPAB; SMAD4; PPARG; HDAC4; TRIM28; HIF1A; EPAS1
Function transcription corepressor activity
Related Protein DAXX; CTBP2; CRYM; BATF3; WTIP; ATN1; BASP1; SMYD1; MSC; CDYL
Function contributes_to transcription factor activity, sequence-specific DNA binding
Related Protein MAFGB; TRIM28; FOXH1; SOX19B; NKX2; RXRA; TAF12; TAF7; VDRB; NFE2L2A
Function ubiquitin protein ligase binding
Related Protein H2-AB1; FANCL; PDE4D; NEDD8; DLG3; CDC34B; ARRB1; TRIB1; IKBKG; SPG20
Function ubiquitin-protein transferase activity
Related Protein UBE2D2A; TRIM71; FBXW2; FBXL14; FBXO40.1; UBE2C; ITCHA; RC3H2; TRAF2; MDM2
Function zinc ion binding
Related Protein TRIM43; TRIM43C; MEX3C; PCGF3; VPS8; MORC1; ZMAT2; MICALL2B; EHMT1A; Alb

Interacting Protein

TRIM28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM28 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM28.
MAGEC2; CBX5

TRIM28 Related Articles

Addison, JB; Koontz, C; et al. KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells. CANCER RESEARCH 75:344-355(2015).
Lee, M; Dworkin, AM; et al. Metastasis-Associated Protein Ribosomal RNA Processing 1 Homolog B (RRP1B) Modulates Metastasis through Regulation of Histone Methylation. MOLECULAR CANCER RESEARCH 12:1818-1828(2014).