TRIM5 Protein, tripartite motif containing 5


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Official Full Name tripartite motif containing 5
Background The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms TRIM5; tripartite motif containing 5; tripartite motif-containing protein 5; RNF88; TRIM5alpha; tripartite motif protein TRIM; tripartite motif protein TRIM5; ring finger protein 88; tripartite motif containing 5 transcript variant iota; tripartite motif
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TRIM5-444H Recombinant Human TRIM5 Protein, His-tagged E.coli His
    Human TRIM5-770HCL Recombinant Human TRIM5 293 Cell Lysate HEK293 N/A
    Mouse Trim5-1696M Recombinant Mouse Trim5 protein, His-tagged E.coli His
    Cynomolgus Monkey TRIM5-1049C Recombinant Cynomolgus TRIM5 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque TRIM5-4970R Recombinant Rhesus monkey TRIM5 Protein, His-tagged Mammalian Cell His

    TRIM5 involved in several pathways and played different roles in them. We selected most pathways TRIM5 participated on our site, such as Cytokine Signaling in Immune system, Immune System, Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine Signaling in Immune system LGALS9; DUSP2; FGF10B; EDARADD; IFIT2; CASPBL; GBP5; SAMHD1; PELI2; DUSP10
    Immune System TRIM38; LRRFIP1; CASP4; BTR06; TRIM8; ASB8; OSBPL1A; DEFB119; MYO9B; HBL3
    Interferon Signaling IFI27; TRIM29; ADAR; ISG20; IFIT3; IFI30; TRIM17; TRIM5; TRIM6; OASL
    Interferon gamma signaling TRIM38; OASL; GBP2; GBP5; GBP1; TRIM10; TRIM46; TRIM8; IRF4; TRIM5

    TRIM5 has several biochemical functions, for example, identical protein binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM5 itself. We selected most functions TRIM5 had, and list some proteins which have the same functions with TRIM5. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding DAPK1; IIGP1; GYPA; ATXN10; DVL1; CEP170L; SF1; GLE1; FGFR1; SH3GLB1
    ligase activity UBE2NA; RNF146; CBX4; TRIM22; MYLIP; DTX1; IRF2BP1; MID2; UBE1Y1; HERC5
    protein binding TRAF7; POLI; NAA10; UACA; TREML2; SPATA2; SRSF5; HIST1H3D; ID1; ANG
    protein binding, bridging CAV1; FSCN2; NEFH; CNTLN; DSP; TRIM22; CBX5; SLC9A1; TJP2; TRIM5
    protein homodimerization activity MAPK4; TKT; TMEM192; NOD1; SETMAR; HPGD; ECT2; FBXO4; ANO6; ATPIF1B
    protein kinase binding IKBKB; CDK5RAP1; TUBB3; THY1; TRAF3; TOM1L1; LAT; CACNB4; PGAM1; DNAJA3
    signaling pattern recognition receptor activity MARCO; DMBT1; COLEC12; TLR2; CLEC7A; TRIM5; FCN1
    ubiquitin-protein transferase activity RNF187; DTX3L; UBR3; FBXW11; RNF144B; PDZRN3B; TRIM5; UBA7; TOPORS; UBE2E2
    zinc ion binding CPA6; RFPL3; ZDHHC15; ADAM22; PHF23B; PDLIM7; CHURC1; ASH1L; BIRC7; TRAF5

    TRIM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM5.


    Ferguson, D; Mattiuzzo, G; et al. Early Biodistribution and Persistence of a Protective Live Attenuated SIV Vaccine Elicits Localised Innate Responses in Multiple Lymphoid Tissues. PLOS ONE 9:-(2014).
    Schneider, A; Wagner, A; et al. Problems and Prospects of Gene Therapy Against HIV. PHARMACEUTICAL CHEMISTRY JOURNAL 47:627-635(2014).

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