Recombinant Human TRIM5 Protein, His-tagged

• Cat.No.: TRIM5-444H
• Product Overview: Recombinant Human TRIM5, transcript variant gamma, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Form: Supplied as a 0.2 µM filtered solution of 20mM PB, 150mM NaCl, pH7.4
• Molecular Mass: 30.8kD
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRISYQPENIRPNRHVANIVEKLREVKLSPEGQKVDHCARHGEKLLLFCQEDGKVICWLCERSQEHRGHHTFLTEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKASWKTQIQYDKTNVLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQTQSLRELISDL
• Endotoxin: Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining

Gene Information

• Gene Name: TRIM5 tripartite motif containing 5 [ Homo sapiens ]
• Official Symbol: TRIM5
• Synonyms: TRIM5; tripartite motif containing 5; tripartite motif-containing protein 5; RNF88; TRIM5alpha; tripartite motif protein TRIM; tripartite motif protein TRIM5; ring finger protein 88; tripartite motif containing 5 transcript variant iota; tripartite motif containing 5 transcript variant kappa
• Gene ID: 85363
• mRNA Refseq: NM_033034
• Protein Refseq: NP_149023
• MIM: 608487
• UniProt ID: Q9C035