TRPC6

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TRPC6

Official Full Name transient receptor potential cation channel, subfamily C, member 6
Background The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
Synonyms TRPC6; transient receptor potential cation channel, subfamily C, member 6; TRP6; FSGS2; short transient receptor potential channel 6; TRP-6; transient receptor protein 6; focal segmental glomerulosclerosis 2;
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TRPC6-347H Recombinant Human TRPC6 Protein, His-tagged E.coli His
    Human TRPC6-741HCL Recombinant Human TRPC6 293 Cell Lysate HEK293 N/A

    TRPC6 involved in several pathways and played different roles in them. We selected most pathways TRPC6 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway SLC25A6; PDE5A; AKT1; CALML5; PRKG2; ATP1A3; MYLK; KCNMB3; PPP1R12A; ATF4

    TRPC6 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPC6 itself. We selected most functions TRPC6 had, and list some proteins which have the same functions with TRPC6. You can find most of the proteins on our site.

    Function Related Protein
    inositol 1,4,5 trisphosphate binding TRPC5A; AKR1C1; RPH3A; PLCL1; TRPC7; TRPC2B; TRPC4; TRPC3; TRPC1; TRPC7A
    protein binding SRPK2; DCBLD2; MYD88; DNAJC10; NRXN1; TRAF3; LSM4; SKAP2; ABLIM3; CD1d1
    store-operated calcium channel activity TRPC2B; TRPC4; ORAI2; ORAI1B; ORAI3; ZP3; TRPC5A; TRPC6; STIM2; TRPC7A

    TRPC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPC6.

    MX1; ITPR3

    Zhang, JC; Mao, XB; et al. IL-17A CONTRIBUTES TO BRAIN ISCHEMIA REPERFUSION INJURY THROUGH CALPAIN-TRPC6 PATHWAY IN MICE. NEUROSCIENCE 274:419-428(2014).
    Abkhezr, M; Dryer, SE; et al. Angiotensin II and Canonical Transient Receptor Potential-6 Activation Stimulate Release of a Signal Transducer and Activator of Transcription 3-Activating Factor from Mouse Podocytes. MOLECULAR PHARMACOLOGY 86:150-158(2014).

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