trpc6
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  • Official Full Name
  • transient receptor potential cation channel, subfamily C, member 6
  • Background
  • The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
  • Synonyms
  • TRPC6; transient receptor potential cation channel, subfamily C, member 6; TRP6; FSGS2; short transient receptor potential channel 6; TRP-6; transient receptor protein 6; focal segmental glomerulosclerosis 2;
Cat.#:TRPC6-347HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRPC6 Protein, His-tagged
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Cat.#:TRPC6-741HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRPC6 293 Cell Lysate
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Cat.#:CSC-RI0194Tag:
Source (Host):Species:Human
Product nameHuman TRPC6 Stable Cell Line-HEK293
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Cat.#:CSC-RI0195Tag:
Source (Host):Species:Human
Product nameHuman TRPC6 Stable Cell Line-HEK293
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Involved Pathway

TRPC6 involved in several pathways and played different roles in them. We selected most pathways TRPC6 participated on our site, such as cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPC6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
IRS1; CALML5; ATP2A2; MEF2C; ATP2A3; ROCK2; PIK3R5; VDAC2; ATP1B4; ATP2B1

Protein Function

TRPC6 has several biochemical functions, for example, inositol 1,4,5 trisphosphate binding, protein binding, store-operated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPC6 itself. We selected most functions TRPC6 had, and list some proteins which have the same functions with TRPC6. You can find most of the proteins on our site.
Function
Related Protein
Function inositol 1,4,5 trisphosphate binding
Related Protein TRPC6A; AKR1C1; TRPC1; TRPC2B; TRPC5A; TRPC2; PLCL1; TRPC5; RPH3A; TRPC7A
Function protein binding
Related Protein DDX23; TLE4; ERCC6L; CTBP2; ZNF567; RBM41; FAM158A; IQSEC3; PLEKHA1; NDUFA4
Function store-operated calcium channel activity
Related Protein TRPC5; TRPC4; TRPC6; TRPC5A; TRPC1; ORAI2; TRPC2; ORAI3; ZP3; ORAI1

Interacting Protein

TRPC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPC6.
MX1; ITPR3

TRPC6 Related Articles

Zhang, JC; Mao, XB; et al. IL-17A CONTRIBUTES TO BRAIN ISCHEMIA REPERFUSION INJURY THROUGH CALPAIN-TRPC6 PATHWAY IN MICE. NEUROSCIENCE 274:419-428(2014).
Abkhezr, M; Dryer, SE; et al. Angiotensin II and Canonical Transient Receptor Potential-6 Activation Stimulate Release of a Signal Transducer and Activator of Transcription 3-Activating Factor from Mouse Podocytes. MOLECULAR PHARMACOLOGY 86:150-158(2014).