|Official Full Name||tuberous sclerosis 1|
|Background||The tuberous sclerosis 1 protein interacts with TSC2 (tuberin) to form a functional tumor suppressor complex that regulates cell proliferation and growth. Tuberous sclerosis is an autosomal dominant tumor suppressor gene syndrome due to inactivating mutations in either TSC1 or TSC. The TSC1/TSC2 complex functions as a negative regulator of mTOR activity and inhibits 70S6K and 4EBP1 phosphorylation in cells. The mechanism of inhibition is to due in part to intrinsic GAP activity acting upon the small GTPase, Rheb. The PI-3K pathway inhibits TSC1/TSC2 via Akt phosphorylation and subsequent destabilization of the functional TSC1/TSC2 complex. Activation of the complex occurs via AMPK,Which senses stress and energy levels in the cell. Phosphorylation of the TSC1/TSC2 complex by AMPK results in activation of the complex and inhibition of mTOR activity.|
|Synonyms||TSC1; tuberous sclerosis 1; TSC; hamartin; KIAA0243; LAM; tumor suppressor; tuberous sclerosis 1 protein; MGC86987|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
TSC1 involved in several pathways and played different roles in them. We selected most pathways TSC1 participated on our site, such as Phospholipase D signaling pathway, mTOR signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Phospholipase D signaling pathway||RALB; MAPK1; GAB1; MAP2K1; SHC1; CXCR1; GRM5; SHC3; RRAS2; PLA2G4F|
|mTOR signaling pathway||EIF4BB; TSC2; RPS6KB2; VEGFAB; EIF4EA; PDPK1; PRR5; RB1CC1; IGF1; PIK3R3A|
|PIK-Akt signaling pathway||GNG13; YWHAE; FGF3; FGF8; MDM2; F2R; PIK3R3; ITGB8; FGFR3; MAPK1|
|AMPK signaling pathway||PFKM; PIK3CB; PCK1; RAB2A; PPP2R5C; INSR; RPS6KB1; CCND1; ULK1; CPT1B|
|Insulin signaling pathway||PRKAA2; PTPRF; FLOT1A; PRKAG3B; GRB2A; PIK3R1; MKNK1; PRKACA; RAPGEF1B; PPP1R3C|
|Choline metabolism in cancer||HRAS; WASF3; PDPK1; MAP2K2; SLC22A5; FOS; EIF4EBP1; TSC2; SLC22A2; PLA2G4B|
TSC1 has several biochemical functions, for example, GTPase activating protein binding, GTPase regulator activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC1 itself. We selected most functions TSC1 had, and list some proteins which have the same functions with TSC1. You can find most of the proteins on our site.
|GTPase activating protein binding||CDH1; TUBB; PTBP3; GNAI3; GNAO1; GAPVD1; PLCD1; FMNL1; PIN1; TSC1|
|GTPase regulator activity||GPSM2; GPSM1B; RGS12B; TSC1A; RUNDC3A; PCP2; KRIT1; ARL2BP; TSC1; GPSM3|
|chaperone binding||DNAJA3A; DNAJB4; VWF; DNAJB2; BAG2; SLC25A17; PFDN6; PRNP; PFDN4; PARK2|
|protein N-terminus binding||SCFD1; PDCD10; THAP7; SLA2; PEX14; DAXX; MEN1; CSNK2A2; SERPINB1A; SDCBP|
|protein binding||GTF2H2C_2; AQP1; TXK; COPS4; RBM22; DYNC1LI1; NUPL1; IGFL1; ATRNL1; SOX4|
TSC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC1.
TSC2; IKBKB; YWHAG; NGFRAP1