TSG101

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TSG101

Official Full Name tumor susceptibility 101
Background The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
Synonyms TSG101; tumor susceptibility 101; TSG10; VPS23; tumor susceptibility gene 101 protein; tumor susceptibility gene 10; tumor susceptibility protein; tumor susceptibility gene 101; ESCRT-I complex subunit TSG101;
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • GST
    • His
    • SUMO
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TSG101-2357H Recombinant Human Tumor Susceptibility Gene 101, His-tagged E.coli His
    Human TSG101-30749TH Recombinant Human TSG101, His-tagged E.coli His
    Human TSG101-30750TH Recombinant Human TSG101, His-tagged E.coli His
    Human TSG101-32H Recombinant Human TSG101 protein, GST-tagged Wheat Germ GST
    Human TSG101-3445H Recombinant Human TSG101 protein, His-sumo/Myc-tagged E.coli His/SUMO/Myc
    Human TSG101-609H Recombinant Human TSG101 Protein, DDK-tagged Sf9 Insect Cell DDK
    Human TSG101-719HCL Recombinant Human TSG101 293 Cell Lysate HEK293 N/A
    Rat TSG101-6314R Recombinant Rat TSG101 Protein Mammalian Cell His
    Rhesus Macaque TSG101-4992R Recombinant Rhesus monkey TSG101 Protein, His-tagged Mammalian Cell His
    Chicken TSG101-4819C Recombinant Chicken TSG101 Mammalian Cell His

    TSG101 involved in several pathways and played different roles in them. We selected most pathways TSG101 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSG101 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis HLA-F; FMNL3; HSPA1A; CXCR1; ADRBK2; SPG20A; ADRB3B; EPS15; CHMP2A; ARPC5B

    TSG101 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by TSG101 itself. We selected most functions TSG101 had, and list some proteins which have the same functions with TSG101. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding OTPA; SWAP70; HOXC12A; IMPDH2; HER9; DLX2A; KIF22; MSGN1; SMARCB1; EF1
    calcium-dependent protein binding SELP; SYT8; PDCD6IP; STX1A; SYT1; KCNIP3; FCN2; C9orf9; CHP; CLEC4M
    ligand-dependent nuclear receptor transcription coactivator activity CARM1; HELZ2; PPARG; LRP2BP; PRKCBB; PPARGC1A; HMGA1-RS1; TADA3; ZMIZ2; BUD31
    protein binding SIVA1; ZMAT2; ATP6AP2; ACTL7A; HTR6; FAM20A; ICAM1; ACOT7; ACAP1; NKX2-1
    protein homodimerization activity APOA4; SRR; CAMK2B; SLK; TCF3A; ACCS; GSTA4; ANO2; S100A1; NKX2
    transcription corepressor activity CITED2; MXI1; SIRT1; CBX4; BCL11A; NPAT; CSDA; TGIF1; CIR1; CBFA2T2
    ubiquitin binding RNF31; VPS28; UCHL3; RBCK1; TRP53INP2; OTUB1; SHRPRBCK1R; UBXN11; SIRT2; FAF1
    ubiquitin protein ligase binding MDM2; CUL9; PER1; UBE2K; CUL4B; SCN5A; BCL10; PINK1; PACRG; SUMO2
    virion binding PPIA; PVRL1; HIPK2; APCS; PTX3; CLEC4M; HSP90B1; CD209; TSG101

    TSG101 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSG101 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSG101.

    CEP55; VPS28; LRSAM1

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