tsg101
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  • Official Full Name
  • tumor susceptibility 101
  • Background
  • The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TSG101; tumor susceptibility 101; TSG10; VPS23; tumor susceptibility gene 101 protein; tumor susceptibility gene 10; tumor susceptibility protein; tumor susceptibility gene 101; ESCRT-I complex subunit TSG101;
Cat.#:TSG101-2357HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Susceptibility Gene 101, His-tagged
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Cat.#:TSG101-30749THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TSG101, His-tagged
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Cat.#:TSG101-30750THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TSG101, His-tagged
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Cat.#:TSG101-32HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TSG101 protein, GST-tagged
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Cat.#:TSG101-3445HTag:His-sumo/Myc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TSG101 protein, His-sumo/Myc-tagged
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Cat.#:TSG101-609HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human TSG101 Protein, DDK-tagged
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Cat.#:TSG101-6314RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TSG101 Protein
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Cat.#:TSG101-4992RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TSG101 Protein, His-tagged
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Cat.#:TSG101-4819CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TSG101
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Cat.#:TSG101-719HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TSG101 293 Cell Lysate
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Involved Pathway

TSG101 involved in several pathways and played different roles in them. We selected most pathways TSG101 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSG101 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
RAB5B; TRAF6; ARFGEF2; CDC42L; CHMP2B; LDLRAP1; WASB; VPS4A; WASL; VPS4B

Protein Function

TSG101 has several biochemical functions, for example, DNA binding, calcium-dependent protein binding, ligand-dependent nuclear receptor transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TSG101 itself. We selected most functions TSG101 had, and list some proteins which have the same functions with TSG101. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF157; ZBED5; MLXIPL; VEZF1; HIST1H2B7; MIER3; JRK; HOXD11A; UBN2B; FOSL1A
Function calcium-dependent protein binding
Related Protein STX1A; CASQ2; ANXA7; CHP1; C9orf9; SYN1; CALM3; TNNC1; MMP13; VAMP2
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein DCAF6; MED1; PPARGC1A; THRAP3; MED30; CCAR1; CALCOCO1; SLC30A9; HMGA1-RS1; PRKCB
Function protein binding
Related Protein PBX2; DIP2A; C20orf20; SDCCAG3; OLIG1; ZNHIT3; TCF25; EIF3B; KIF21A; MAP4K4
Function protein homodimerization activity
Related Protein PEX11B; CARM1; NAMPT; RENBP; CHMP1A; RASGRP1; ATIC; PDZD7; HRSP12; LRRK2
Function transcription corepressor activity
Related Protein NPAT; ZMYND11; NOC2L; SIAH2; HSF4; LMCD1; RUNX1T1; MECP2; PRMT5; DAXX
Function ubiquitin binding
Related Protein FAM125A; USP5; RBCK1; DYRK2; SHRPRBCK1R; UCHL3; DNAJC2; UBR5; SMAD3; NBR1
Function ubiquitin protein ligase binding
Related Protein VCP; HSPA9; ABI2; YWHAZ; XBP1; UBE2K; PACRG; SMAD3; MAGEA2B; FZD6
Function virion binding
Related Protein APCS; PVRL1; PTX3; HSP90B1; CLEC4M; CD209; HIPK2; TSG101; PPIA

Interacting Protein

TSG101 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSG101 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSG101.
CEP55; VPS28; LRSAM1