• Official Full Name
  • tumor susceptibility 101
  • Background
  • The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TSG101; tumor susceptibility 101; TSG10; VPS23; tumor susceptibility gene 101 protein; tumor susceptibility gene 10; tumor susceptibility protein; tumor susceptibility gene 101; ESCRT-I complex subunit TSG101;
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Susceptibility Gene 101, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TSG101, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TSG101, His-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TSG101 protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TSG101 protein, His-sumo/Myc-tagged
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human TSG101 Protein, DDK-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TSG101 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TSG101 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TSG101
Source (Host):Species:Human
Product nameRecombinant Human TSG101 293 Cell Lysate

Involved Pathway

TSG101 involved in several pathways and played different roles in them. We selected most pathways TSG101 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSG101 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein

Protein Function

TSG101 has several biochemical functions, for example, DNA binding, calcium-dependent protein binding, ligand-dependent nuclear receptor transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TSG101 itself. We selected most functions TSG101 had, and list some proteins which have the same functions with TSG101. You can find most of the proteins on our site.
Related Protein
Function DNA binding
Related Protein RUNX1T1; RHOXF1; ZNF358; PPARA; SOX21B; ZFP354A; ZFP276; MED26; CREMB; CHRAC1
Function calcium-dependent protein binding
Related Protein SYT8; ANXA7; CCDC167; PLSCR3; STX1A; ALG2; S100A11; KCNIP3; STMN2; S100A1
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein MED17; KDM1A; MED24; MED30; PPARGC1B; AASS; HMGA1; PPRC1; ATXN7L3; NCOA2
Function protein binding
Related Protein NEFL; ZNF488; POU2F1; VTN; MAP1B; CD247; HSPE1; OLIG1; SNX6; SCFD1
Function protein homodimerization activity
Related Protein CR2; SLC11A1; PLOD1; SPPL2B; ADD1; EEA1; CALCOCO2; MTERFD3; LCN2; APOC2
Function transcription corepressor activity
Related Protein CCND1; CITED2; DAXX; KCNA3; CCAR1; ZNF136; ZNF274; DR1; E2F8; MTA1
Function ubiquitin binding
Related Protein TOM1L1; FAM125A; SPRTN; VPS28; FAF2; TRP53INP2; TRIM32; C36E6.2; SHRPRBCK1R; DYRK2
Function ubiquitin protein ligase binding
Related Protein DERL1; GPR19; SMAD7; SMAD6; TRP53; MAP1LC3B; CCDC50; ATXN3; GGN; CBS
Function virion binding
Related Protein PTX3; HIPK2; PVRL1; CD209; PPIA; APCS; TSG101; CLEC4M; HSP90B1

Interacting Protein

TSG101 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSG101 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSG101.