tuba1a
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  • Official Full Name
  • tubulin, alpha 1a
  • Background
  • Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.
  • Synonyms
  • TUBA1A; tubulin, alpha 1a; tubulin alpha-1A chain; B ALPHA 1; FLJ25113; TUBA3; tubulin; alpha; brain specific; hum-a-tub1; hum-a-tub2; alpha-tubulin 3; tubulin, alpha 3; tubulin B-alpha-1; tubulin alpha-3 chain; tubulin, alpha, brain-specific; LIS3; B-ALP
Cat.#:TUBA1A-106HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TUBA1A, GST-tagged
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Cat.#:TUBA1A-107HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TUBA1A, GST-tagged
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Cat.#:TUBA1A-16HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TUBA1A protein, MYC/DDK-tagged
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Cat.#:TUBA1A-17HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TUBA1A protein, GST-tagged
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Cat.#:TUBA1A-18HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TUBA1A protein, GST-tagged
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Cat.#:TUBA1A-31628THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TUBA1A, His-tagged
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Cat.#:TUBA1A-17608MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TUBA1A Protein
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Cat.#:TUBA1A-6354RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TUBA1A Protein
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Cat.#:TUBA1A-662HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TUBA1A 293 Cell Lysate
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Involved Pathway

TUBA1A involved in several pathways and played different roles in them. We selected most pathways TUBA1A participated on our site, such as Phagosome, Gap junction, Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TUBA1A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
HLA-F; ATP6V1AA; TUBA8L; HLA-DRB3; CCDC102A; TFRC; HGS; HLA-DMB; NCF2; TFR1A
Gap junction
CX43; DRD2B; GNAI1; TUBA7L; TUBA3D; TUBA1C; GNAI2A; PLCB1; HRASA; HTR2B
Pathogenic Escherichia coli infection
TUBA4A; CTTN; TUBA3E; TUBB6; ARPC5L; TUBA3D; CLDN1; TUBA3C; TUBA1B; WASL

Protein Function

TUBA1A has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TUBA1A itself. We selected most functions TUBA1A had, and list some proteins which have the same functions with TUBA1A. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein EHD1B; TUBE1; TUBB2; NME1; ARL8A; GNAI2B; RAB33BA; SEPHS1; GTPBP10; IIGP1
Function GTPase activity
Related Protein RHOF; RASD2; RHOD; TUBA4L; GNB3; TUBG2; GNA14; RAB42; RHOB; RHOU
Function protein binding
Related Protein Txn1; DRD1; SCNN1B; VSIG4; CRHBP; BLOC1S3; ATP7A; HPN; PKD2L1; TYRP1
Function protein domain specific binding
Related Protein XPA; YWHAG1; MRPS31; DVL2; Ar; PRKCZ; ACSL3; STRN4; GABRR1; CENPJ
Function structural constituent of cytoskeleton
Related Protein ARPC2; ACTR3; ACTL6B; TUBB5; TUBA8L2; ARPC5; CYLC2; NDC80; SPTAN1; TUBA8L3
Function structural molecule activity
Related Protein CLDN5B; ISCA1; ADD1; COPG2; CLDN10A; LCE3D; KRT95; COPB2; KRT7; CLDNJ

Interacting Protein

TUBA1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TUBA1A here. Most of them are supplied by our site. Hope this information will be useful for your research of TUBA1A.
EGFR; CYLD; LRRK2; HDAC6; HTRA2; MYO10; LTA; LGALS2; JUN; NCK1; NFKBIA

TUBA1A Related Articles

Romaniello, R; Arrigoni, F; et al. Mutations in alpha- and beta-tubulin encoding genes: Implications in brain malformations. BRAIN & DEVELOPMENT 37:273-280(2015).
McMichael, G; Bainbridge, MN; et al. Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy. MOLECULAR PSYCHIATRY 20:176-182(2015).