Tlr6
-
Official Full Name
toll-like receptor 6
-
Overview
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations. -
Synonyms
TLR6; toll-like receptor 6; CD286; OTTHUMP00000218187; CD286 antigen; TLR 6; Toll like receptor 6 precursor; OTTHUMP00000218188; OTTHUMP00000158730;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Rhesus monkey
- CHO
- E.coli
- HEK293
- Human Cell
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- C
- His
- Fc
- Fc Chimera
- hIgG1
- hIgG4
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Tlr6 Related Articles
- Tlr6 Related Research Area
Tlr6 involved in several pathways and played different roles in them. We selected most pathways Tlr6 participated on our site, such as Activated TLR4 signalling, Chagas disease (American trypanosomiasis), Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tlr6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Activated TLR4 signalling | ALCAMB;DUSP4;DUSP3;MAP3K8;RIPK3;UBE2V1;DHX9;S100B;TNIP2 |
Chagas disease (American trypanosomiasis) | IKBKB;PIK3CB;PPP2R2B;CASP8;TGFB2;CD247;GNA14;CCL3;GNAI2 |
Disease | NPM1;TCEB3;CTDP1;APOBEC3G;STRA6;TCEA1;DOCK2;TRAT1;NUP50 |
Diseases associated with the TLR signaling cascade | TICAM1;TLR6;TIRAP;TLR10 |
Diseases of Immune System | TLR6;TIRAP;TLR10 |
IRAK4 deficiency (TLR2/4) | TLR6;TIRAP |
Immune System | LILRB2;MASP2;WASF3;KLHL21;RCA2.1;TRIM9;IFIT11;NLRC5;RNF14 |
Innate Immune System | CFHL4;MGC174152;TXNIPA;DUSP3B;DEFA1;MYO1C;POLR3GLA;CTS7;BTR16 |
Tlr6 has several biochemical functions, for example, Toll-like receptor 2 binding, diacyl lipopeptide binding, lipopeptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tlr6 itself. We selected most functions Tlr6 had, and list some proteins which have the same functions with Tlr6. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
Toll-like receptor 2 binding | TLR1;TLR6;TIRAP |
diacyl lipopeptide binding | TLR2;TLR6 |
lipopeptide binding | CD1D2;CD1E;CD1A;CD1D;TLR6;CD1B;CD1d1;CD1C |
protein binding | TRIM41;ZBTB22;PEA15;CLEC16A;FBXW9;ZNF232;CHMP1B;KIF13B;CREB5 |
protein heterodimerization activity | FZD1;SMAD2;HIST1H2B5;ENO3;H2AFY2;H2AFVA;CREB3L3;ADD1;NOTCH4 |
receptor activity | PVRL3;NOTCH1B;TNFRSF10A;AMFR;TIGIT;EIF2D;LILRB2;F2RL1.2;CD86 |
transmembrane signaling receptor activity | OR12D3;GPR133;TNFRSF11A;CLEC2D;OR2A4;FCAMR;NRXN2;TLR2-1;SIGLEC8 |
Tlr6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tlr6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tlr6.
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All Tlr6 Products
Required fields are marked with *
My Review for All Tlr6 Products
Required fields are marked with *