tlr6
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  • Official Full Name
  • toll-like receptor 6
  • Background
  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.
  • Synonyms
  • TLR6; toll-like receptor 6; CD286; OTTHUMP00000218187; CD286 antigen; TLR 6; Toll like receptor 6 precursor; OTTHUMP00000218188; OTTHUMP00000158730
Cat.#:TLR6-3259HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR6, His-tagged
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Cat.#:TLR6-422HTag:Fc Chimera
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human TLR6, Fc Chimera
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Cat.#:TLR6-781HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR6 protein, His & T7-tagged
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Cat.#:Tlr6-444MTag:Fc Chimera
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Tlr6, Fc Chimera
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Cat.#:Tlr6-782MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tlr6 protein, His & T7-tagged
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Cat.#:TLR6-1676RTag:N/A
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR6 Protein
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Cat.#:TLR6-1677RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR6 Protein, hIgG1-tagged
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Cat.#:TLR6-1678RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR6 Protein, hIgG4-tagged
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Cat.#:TLR6-4735RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TLR6 Protein, His-tagged
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Cat.#:Tlr6-2433MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Toll-like Receptor 6, Fc Chimera
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Cat.#:TLR6-1044HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TLR6 293 Cell Lysate
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Involved Pathway

Tlr6 involved in several pathways and played different roles in them. We selected most pathways Tlr6 participated on our site, such as Activated TLR4 signalling, Chagas disease (American trypanosomiasis), Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tlr6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activated TLR4 signalling
IRAK3; ATF2; TANK; MAPK14; JUN; RIPK3; MAPKAPK2B; DUSP3B; DUSP7; DUSP4
Chagas disease (American trypanosomiasis)
AKT1; BDKRB2; MAPK12; NFKB1; CD3D; CFLAR; IRAK1; MYD88; IKBKG; MAPK9
Disease
EPM2A; JAG2; PSTPIP2; STRA6; KPNA3; SFTPC; DOCK2; TRAT1; OGN; GPC5
Diseases associated with the TLR signaling cascade
TLR10; TLR6; TIRAP; TICAM1
Diseases of Immune System
TLR10; TLR6; TIRAP
IRAK4 deficiency (TLR2/4)
TLR6; TIRAP
Immune System
ASB2; ARIH2; GBP2; CYBB; KIF3C; BTR06; CYBA; SOCS3A; KIF4A; CFHL1
Innate Immune System
NLRC5; FAM49BA; SIGLEC14; CD300LB; CFHL4; GZMM; NLRP4B; CLEC4A; BAIAP2; CYLD

Protein Function

Tlr6 has several biochemical functions, for example, Toll-like receptor 2 binding, diacyl lipopeptide binding, lipopeptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tlr6 itself. We selected most functions Tlr6 had, and list some proteins which have the same functions with Tlr6. You can find most of the proteins on our site.
Function
Related Protein
Function Toll-like receptor 2 binding
Related Protein TLR1; TIRAP; TLR6
Function diacyl lipopeptide binding
Related Protein TLR2; TLR6
Function lipopeptide binding
Related Protein CD1D; TLR6; CD1E; CD1d1; CD1D2; CD1A; CD1C; CD1B
Function protein binding
Related Protein ERN1; GSG2; CDC23; TAP1; TUFT1; TRAPPC6B; ATF4; SMARCD3; ZBED3; SH3GL2
Function protein heterodimerization activity
Related Protein BTBD11A; HIST1H4F; SMAD2; ADRB1; CUL5; CHRNB2; DLG4B; SPTA1; GCLC; PPARD
Function receptor activity
Related Protein TNFRSF11B; CMKLR1; PLXNA1; CUBN; Tnfrsf22; CD200R4; KLRC4-KLRK1; TNFRSF13B; RRBP1B; PVR
Function transmembrane signaling receptor activity
Related Protein TLR2-2; KLRD1; CD79B; FCGR2C; TNFRSF10D; CD3E; ANTXR1; GPR98; LYVE1; ADCYAP1R1A

Tlr6 Related Articles

Ammerdorffer, A; Schoffelen, T; et al. Recognition of Coxiella burnetii by Toll-like Receptors and Nucleotide-Binding Oligomerization Domain-like Receptors. JOURNAL OF INFECTIOUS DISEASES 211:978-987(2015).
Zhang, XJ; Xu, J; et al. Expression and function of Toll-like receptors in peripheral blood mononuclear cells from patients with ovarian cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:275-286(2015).