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Official Full Name ubiquitin-like modifier activating enzyme 2
Background Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Synonyms UBA2; ubiquitin-like modifier activating enzyme 2; ARX; SAE2; HRIHFB2115; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; SUMO-1 activating enzyme subunit 2; ubiquitin-like 1-activating enzyme E1B; anthracycline-associated resistance ARX; ubiquitin-like modifier-activating enzyme 2; UBA2, ubiquitin-activating enzyme E1 homolog;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBA2-4965H Recombinant Human UBA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Uba2-6765M Recombinant Mouse Uba2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human UBA2-253H Recombinant Human UBA2, GST-tagged Sf9 Insect Cell GST
    Human UBA2-3515H Recombinant Human UBA2, GST-tagged E.coli GST
    Human UBA2-606HCL Recombinant Human UBA2 293 Cell Lysate HEK293 N/A
    Chicken UBA2-2284C Recombinant Chicken UBA2 Mammalian Cell His
    Zebrafish UBA2-12542Z Recombinant Zebrafish UBA2 Mammalian Cell His

    UBA2 involved in several pathways and played different roles in them. We selected most pathways UBA2 participated on our site, such as Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of proteins SAE1; EXOC8; ST6GALNAC2; APCS; ST8SIA3; IGFBP6B; CDX2; YY2; PAPPA2; TIMM44
    Post-translational protein modification GALNTL2; PREB; TRAPPC4; MGAT4B; THSD1; MUCL1; KCNA6; DAD1; UBA2; TRAPPC6A
    Processing and activation of SUMO SENP5; UBA2; SENP1; SAE1
    SUMO is conjugated to E1 (UBA2:SAE1) SAE1; UBA2
    SUMO is transferred from E1 to E2 (UBE2I, UBC9) SAE1; UBA2
    SUMOylation PHC1; SCMH1; SMC5; RNF2; PHC3; SAE1; PHC2; UBA2; NSMCE2; NSMCE1
    Ubiquitin mediated proteolysis UBR5; CUL5; FBXO2; FBXO4; UBE2L3B; FANCL; SOCS3; UBE2Q1; PARK2; TCEB1

    UBA2 has several biochemical functions, for example, ATP binding, SUMO activating enzyme activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA2 itself. We selected most functions UBA2 had, and list some proteins which have the same functions with UBA2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding P2RX2; DNAH5; CSNK2A2A; MSH4; UBE2KA; HSPA1B; ATP1A3; HIPK2; OXSR1; RFC5
    SUMO activating enzyme activity UBA2
    enzyme activator activity PITRM1; DBNL; MGST2; PRKCE; DCP1A; ALOX5AP; DAOA; SFTPB; RICTOR; SEC14L2
    metal ion binding ZNF843; ZC3H14; NRP2; TGM5; Adamts19; RPE65; NR1D4B; MARCH11; MAP2K5; TDO2A
    protein binding WARS; ECE2; TIA1; MYCBP; CDK4; TRIP12; F3; TRAF3IP3; RBBP8; SENP6
    protein heterodimerization activity IKBKG; HNF1B; TIMELESS; ZFP423; ADRB1; TYRO3; PDZD7; BCL2L10; TGFB2; NFYB
    transcription factor binding HDAC3; TFDP2; HDAC11; DIP2BA; NKX2-5; ARRB1; TAF1; BCL10; DIP2C; CREBBP

    UBA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA2.

    SAE1; g2xkq0_human; SUMO1; UBE2I; MCC; HLA-B; PCBD1; IKBKE; TRAF6; SETX

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