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UBA2

  • Official Full Name

    ubiquitin-like modifier activating enzyme 2

  • Overview

    Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
  • Synonyms

    UBA2; ubiquitin-like modifier activating enzyme 2; ARX; SAE2; HRIHFB2115; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; SUMO-1 activating enzyme subunit 2; ubiquitin-like 1-activating enzyme E1B; anthracycline-associated resistance ARX; ubiquitin-like modifier-activating enzyme 2; UBA2, ubiquitin-activating enzyme E1 homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UBA2-3515H Recombinant Human UBA2, GST-tagged E.coli GST 294-640aa
Human UBA2-253H Recombinant Human UBA2, GST-tagged Sf9 Insect Cell GST
Human UBA2-606HCL Recombinant Human UBA2 293 Cell Lysate HEK293 N/A
Human UBA2-1373HFL Recombinant Full Length Human UBA2 Protein, C-Flag-tagged Mammalian cells Flag
Human UBA2-4965H Recombinant Human UBA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human UBA2-2290H-B Recombinant Human UBA2 Protein Pre-coupled Magnetic Beads HEK293
Human UBA2-2290H Recombinant Human UBA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human UBA2-4935H Recombinant Human UBA2 protein, His-SUMO-tagged E.coli His-SUMO 1-640aa
Human UBA2-520H Recombinant Human UBA2 Protein, His-tagged E.coli N-His Arg453-Ala638
Mouse Uba2-6765M Recombinant Mouse Uba2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Uba2-521M Recombinant Mouse Uba2 Protein, His-tagged E.coli N-His Arg451-Asp638
Zebrafish UBA2-12542Z Recombinant Zebrafish UBA2 Mammalian Cell His
Chicken UBA2-2284C Recombinant Chicken UBA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

UBA2 involved in several pathways and played different roles in them. We selected most pathways UBA2 participated on our site, such as Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolism of proteinsCALCA;THSD1;TUBA1B;INHA;TRAPPC4;PPP6R1;PMPCB;PFDN4;TGFBI
Post-translational protein modificationTRAPPC2;ARSE;ADAMTS15;DPH1;CNIH3;CNIH2;NANP;SENP1;ADAMTS10
Processing and activation of SUMOUBA2;SAE1;SENP5;SENP1
SUMO is conjugated to E1 (UBA2:SAE1)UBA2;SAE1
SUMO is transferred from E1 to E2 (UBE2I, UBC9)SAE1;UBA2
SUMOylationSENP1;SMC5;RNF2;NSMCE1;PHC1;UBA2;SENP5;NSMCE2;RING1
Ubiquitin mediated proteolysisUBE2QL1;SAE1;NHLRC1;ANAPC2;UBE2KA;UBE2L3A;KEAP1B;NEDD4L;CUL4A

UBA2 has several biochemical functions, for example, ATP binding, SUMO activating enzyme activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA2 itself. We selected most functions UBA2 had, and list some proteins which have the same functions with UBA2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCKMT1A;CAD;AFG3L2;UBE2D3;MARK1;MLH3;ENTPD2;CHD1L;ORC1L
SUMO activating enzyme activity
enzyme activator activitySLX4;MMP15;GMFG;SFTPB;DBNL;HSPB2;DCP1A;RICTOR;SFTPBB
metal ion bindingPM20D1.2;PLCD3;CISD3;HBA-X;TAX1BP1;MT2;HDAC8;COL2A1;RNF17
protein bindingIGF2R;MAPK8IP3;ARL4A;NCSTN;KIF3B;OPRK1;GATA6;NCF4;DVL2
protein heterodimerization activityIRAK2;CEBPE;ADORA1;RBP4;HIST4H4;CLNS1A;SPTAN1;HIST1H2B7;SEPHS1
transcription factor bindingTFDP1B;CREBBP;CRY1;SOX8;TBL1X;BPTF;THRA;RBPJ;HES2

UBA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA2.

SAE1; g2xkq0_human; SUMO1; UBE2I; MCC; HLA-B; PCBD1; IKBKE; TRAF6; SETX

  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the correlation between the expression level of UBA2 and disease? 10/01/2023

Studies have shown that UBA2 expression levels are associated with the occurrence and development of certain diseases, including cancer and neurodegenerative diseases.

What are the specific roles of UBA2 in cancer? 06/07/2023

In cancer, UBA2 may contribute to tumorigenesis and development by regulating intracellular protein degradation and signal transduction. It could be a potential target for cancer treatment.

How to detect UBA2 expression level? 01/22/2023

The expression level of UBA2 can be detected by immunohistochemistry, western blot and real-time quantitative PCR.

How about the interactions of UBA2 with other proteins? 12/19/2022

UBA2 can interact with a variety of other proteins, including ubiquitin ligase, proteolytic enzyme, etc. These interactions enable it to regulate processes such as cell growth, differentiation, and apoptosis.

Does there have relationship between the structure and function of UBA2? 01/15/2022

The structure of UBA2 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.

What are the therapeutic strategies for UBA2? 10/20/2021

Therapeutic strategies for UBA2 may include regulating its expression level, inhibiting its enzyme activity, or regulating its associated signal transduction pathways. These methods may have potential applications in the treatment of cancer, neurodegenerative diseases, etc.

Customer Reviews (3)

Write a review
Reviews
05/31/2023

    After UBA2 was used, the background of the Western blot was very clean and there was no non-specific signal.

    10/12/2022

      The recombinant protein in the pathogenesis of related diseases was evaluated by animal models or in vitro experiments, and the effect was found to be good.

      07/04/2021

        This protein has good stability and consistency during large-scale production.

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