| Official Full Name | ubiquitin-like modifier activating enzyme 2 |
| Background | Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010] |
| Synonyms | UBA2; ubiquitin-like modifier activating enzyme 2; ARX; SAE2; HRIHFB2115; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; SUMO-1 activating enzyme subunit 2; ubiquitin-like 1-activating enzyme E1B; anthracycline-associated resistance ARX; ubiquitin-like modifier-activating enzyme 2; UBA2, ubiquitin-activating enzyme E1 homolog; |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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UBA2 involved in several pathways and played different roles in them. We selected most pathways UBA2 participated on our site, such as Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | SAE1; EXOC8; ST6GALNAC2; APCS; ST8SIA3; IGFBP6B; CDX2; YY2; PAPPA2; TIMM44 |
| Post-translational protein modification | GALNTL2; PREB; TRAPPC4; MGAT4B; THSD1; MUCL1; KCNA6; DAD1; UBA2; TRAPPC6A |
| Processing and activation of SUMO | SENP5; UBA2; SENP1; SAE1 |
| SUMO is conjugated to E1 (UBA2:SAE1) | SAE1; UBA2 |
| SUMO is transferred from E1 to E2 (UBE2I, UBC9) | SAE1; UBA2 |
| SUMOylation | PHC1; SCMH1; SMC5; RNF2; PHC3; SAE1; PHC2; UBA2; NSMCE2; NSMCE1 |
| Ubiquitin mediated proteolysis | UBR5; CUL5; FBXO2; FBXO4; UBE2L3B; FANCL; SOCS3; UBE2Q1; PARK2; TCEB1 |
UBA2 has several biochemical functions, for example, ATP binding, SUMO activating enzyme activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA2 itself. We selected most functions UBA2 had, and list some proteins which have the same functions with UBA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | P2RX2; DNAH5; CSNK2A2A; MSH4; UBE2KA; HSPA1B; ATP1A3; HIPK2; OXSR1; RFC5 |
| SUMO activating enzyme activity | UBA2 |
| enzyme activator activity | PITRM1; DBNL; MGST2; PRKCE; DCP1A; ALOX5AP; DAOA; SFTPB; RICTOR; SEC14L2 |
| metal ion binding | ZNF843; ZC3H14; NRP2; TGM5; Adamts19; RPE65; NR1D4B; MARCH11; MAP2K5; TDO2A |
| protein binding | WARS; ECE2; TIA1; MYCBP; CDK4; TRIP12; F3; TRAF3IP3; RBBP8; SENP6 |
| protein heterodimerization activity | IKBKG; HNF1B; TIMELESS; ZFP423; ADRB1; TYRO3; PDZD7; BCL2L10; TGFB2; NFYB |
| transcription factor binding | HDAC3; TFDP2; HDAC11; DIP2BA; NKX2-5; ARRB1; TAF1; BCL10; DIP2C; CREBBP |
UBA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA2.
SAE1; g2xkq0_human; SUMO1; UBE2I; MCC; HLA-B; PCBD1; IKBKE; TRAF6; SETX
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