uba2
Share
  • Official Full Name
  • ubiquitin-like modifier activating enzyme 2
  • Background
  • Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
  • Synonyms
  • UBA2; ubiquitin-like modifier activating enzyme 2; ARX; SAE2; HRIHFB2115; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; SUMO-1 activating enzyme subunit 2; ubiquitin-like 1-activating enzyme E1B; anthracycline-associated resistance ARX; ubiquitin-like modifier-activating enzyme 2; UBA2, ubiquitin-activating enzyme E1 homolog;
Cat.#:UBA2-253HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human UBA2, GST-tagged
+Inquiry
Cat.#:UBA2-3515HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBA2, GST-tagged
+Inquiry
Cat.#:UBA2-2284CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UBA2
+Inquiry
Cat.#:UBA2-12542ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UBA2
+Inquiry
Cat.#:UBA2-606HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human UBA2 293 Cell Lysate
+Inquiry

Involved Pathway

UBA2 involved in several pathways and played different roles in them. We selected most pathways UBA2 participated on our site, such as Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism of proteins
ADAMTS3; IGFBP5B; TRAPPC4; B3GALTL; CEACAM21; NAPAA; GFER; NEU3; NAPG; ADAMTS8
Post-translational protein modification
SUMF2; TRAPPC6BL; THSD1; GALNT5; WDR85; MGAT4A; ADAMTSL5; ARSH; PPP6R3; GALNT6
Processing and activation of SUMO
UBA2; SAE1; SENP1; SENP5
SUMO is conjugated to E1 (UBA2:SAE1)
SAE1; UBA2
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
UBA2; SAE1
SUMOylation
SCMH1; EID3; PHC2; PHC3; NSMCE4A; RING1; UBA2; RNF2; PHC1; NSMCE2
Ubiquitin mediated proteolysis
UBE2NA; RHOBTB2A; UBE2A; UBE2KB; UBA1; CUL4A; UBE2W; UBE2NB; SKP1; SIAH1

Protein Function

UBA2 has several biochemical functions, for example, ATP binding, SUMO activating enzyme activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA2 itself. We selected most functions UBA2 had, and list some proteins which have the same functions with UBA2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PIP4K2B; PAK4; MAP3K3; LIG3; DHX36; MKKS; PRKAG2; ABCC9; ADCY9; ATAD1
Function SUMO activating enzyme activity
Related Protein UBA2
Function enzyme activator activity
Related Protein SLX4; CTAGE5; DCP1B; RAB3GAP2; CASP9; TAB1; DNMT3L; OGT; ASAP2; GMFG
Function metal ion binding
Related Protein ARL3; PRKCE; TGM1; TAF1B; KCNMA1; ZBTB12; NOB1; GNE; PLA2G4F; COL10A1
Function protein binding
Related Protein KNDC1; MRC2; ZNF473; KAT7; SLC30A2; CPSF7; HM13; PARL; RBFA; PRUNE
Function protein heterodimerization activity
Related Protein ADRA1B; JDP2; CLNS1A; HIST1H2AG; CAPN2; HIST1H2AF; HIST1H4G; STX1A; ENO3; HMG20B
Function transcription factor binding
Related Protein EPAS1; PELP1; CTBP1; HAND1; NFATC2; MYOD1; NFKB1; NKX2-5; LMO4; KAT6B

Interacting Protein

UBA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA2.
SAE1; g2xkq0_human; SUMO1; UBE2I; MCC; HLA-B; PCBD1; IKBKE; TRAF6; SETX