ube2t
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  • Official Full Name
  • ubiquitin-conjugating enzyme E2T (putative)
  • Background
  • The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is;transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a;ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 (PubMed;16916645)).
  • Synonyms
  • UBE2T; ubiquitin-conjugating enzyme E2T (putative); ubiquitin-conjugating enzyme E2 T; HSPC150; ubiquitin-protein ligase T; ubiquitin carrier protein T; ubiquitin conjugating enzyme; cell proliferation-inducing gene 50 protein; HSPC150 protein similar to ubiquitin-conjugating enzyme; PIG50
Cat.#:UBE2T-561HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2T Protein (Met1-Val197), His-tagged
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Cat.#:UBE2T-141HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human UBE2T
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Cat.#:UBE2T-142HTag:His/SUMO
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human UBE2T, His-SUMO-tagged
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Cat.#:UBE2T-2355HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2T, His-tagged
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Cat.#:UBE2T-3546HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2T, GST-tagged
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Cat.#:UBE2T-17733MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UBE2T Protein
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Cat.#:UBE2T-4665ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UBE2T
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Cat.#:UBE2T-561HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE2T 293 Cell Lysate
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Involved Pathway

UBE2T involved in several pathways and played different roles in them. We selected most pathways UBE2T participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2T were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fanconi anemia pathway
FANCA; MUS81; FANCE; WDR48; BRCA1; POLI; RPA4; EME2; POLH; POLK

Protein Function

UBE2T has several biochemical functions, for example, ATP binding, chromatin binding, ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2T itself. We selected most functions UBE2T had, and list some proteins which have the same functions with UBE2T. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein GM711; GLULA; OAS1B; MINK1; ATP2B1B; ATP7B; STK25; STRADA; JAK2; ULK1A
Function chromatin binding
Related Protein TGIF1; ARNTL1B; WHSC1; CCDC111; HDAC2; SSRP1; TPR; NEUROD1; NFKB2; NOC3L
Function ubiquitin conjugating enzyme activity
Related Protein UBE2D3; UBE2L3; CDC34; UBE2J2; UBE2S; UBE2D2A; UBE2H; UBE2V2; UBE2N; UBE2G2
Function ubiquitin protein ligase activity
Related Protein COP1; SIAH1A; RNF149; MARCH1; ITCHA; UBR3; MED27; FBXO6; TRIM59; HECTD1
Function ubiquitin protein ligase binding
Related Protein TXNIP; UBE2T; HERC2; LRPPRC; PIAS4; SCAMP3; SLC25A5; SPOP; WASH1; HM13
Function ubiquitin-protein transferase activity
Related Protein TRAF2; UBE2D1; UHRF1; DTX3L; MARCH4; UBE2E3; HECTD1; TRAF6; FBXL14A; TSPAN17

Interacting Protein

UBE2T has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2T here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2T.
ARIH2; UBE2V1; MGRN1; TRIM27; PCGF2; RNF144B; LNX2; RNF128; MARCH5; AMFR; SNURF

UBE2T Related Articles

Renaudin, X; Guervilly, JH; et al. Proteomic analysis reveals a FANCA-modulated neddylation pathway involved in CXCR5 membrane targeting and cell mobility. JOURNAL OF CELL SCIENCE 127:3546-3554(2014).
Hodson, C; Purkiss, A; et al. Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection. STRUCTURE 22:337-344(2014).