ubr4
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  • Official Full Name
  • ubiquitin protein ligase E3 component n-recognin 4
  • Background
  • The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein.
  • Synonyms
  • UBR4; ubiquitin protein ligase E3 component n-recognin 4; zinc finger, UBR1 type 1 , ZUBR1; E3 ubiquitin-protein ligase UBR4; KIAA0462; KIAA1307; RBAF600; 600 kDa retinoblastoma protein associated factor; 600 kDa retinoblastoma protein-associated factor; N-recognin-4; p600; Retinoblastoma associated factor 600 like protein; Retinoblastoma associated factor of 600 kDa; Retinoblastoma-associated factor 600; Retinoblastoma-associated factor of 600 kDa; Ubiquitin protein ligase E3 component n recognin 4; UBR4_HUMAN; Zinc finger UBR1 type protein 1; Zinc finger UBR1-type protein 1; Zinc finger, UBR1 type 1; ZUBR 1; ZUBR1; OTTHUMP00000002585; retinoblastoma-associated factor 600-like protein; RP5-1126H10.1
Cat.#:UBR4-3562HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBR4, His-tagged
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Cat.#:UBR4-17762MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UBR4 Protein
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Involved Pathway

UBR4 involved in several pathways and played different roles in them. We selected most pathways UBR4 participated on our site, such as Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBR4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Viral carcinogenesis
VDAC3; HIST2H4; HIST1H4D; TRAF3; HDAC7; HIST1H2BO; HIST1H2BH; C3; HIST2H2BE; SP100

Protein Function

UBR4 has several biochemical functions, for example, calmodulin binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBR4 itself. We selected most functions UBR4 had, and list some proteins which have the same functions with UBR4. You can find most of the proteins on our site.
Function
Related Protein
Function calmodulin binding
Related Protein MTAP6; MYO1E; UPF3B; IQCB1; INVS; KCNN1; KCNQ1; PHKG1; CAMKK2; CAMK1GB
Function ligase activity
Related Protein PRP19; TRIM4; PIAS4; UBE2G1A; TTLL5; NEDD4L; NAPRT1; MID2; MARCH3; WWP2
Function protein binding
Related Protein BUB3; RAB10; DR1; BAI3; POLL; POU2AF1; CCDC50; RPL10; ENOX2; BRPF1
Function ubiquitin-protein transferase activity
Related Protein UBE2L6; TTC3; RLIM; TRIM21; CBL; UBA7; RFWD3; UBE2R2; TRIM37; TRIM23
Function zinc ion binding
Related Protein NR1D4A; TMEM163; CSRP2; RNF121; MICALL1; RORB; RECQL4; CA9; PHF19; RASGRP1

Interacting Protein

UBR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBR4.
E7; VCAM1; gag-pol; E7; E7; MCRS1; PRPF40A; SRGN; UBE2A; UBE2B; Smad6; Nsfl1c

UBR4 Related Articles

Parsons, K; Nakatani, Y; et al. p600/UBR4 in the central nervous system. CELLULAR AND MOLECULAR LIFE SCIENCES 72:1149-1160(2015).
Aoyagi, N; Watanabe, M; et al. Optical properties of tetravalent uranium complexes in non-aqueous media. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 303:1095-1098(2015).