uchl5
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  • Official Full Name
  • ubiquitin carboxyl-terminal hydrolase L5
  • Background
  • Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) belongs to the peptidase C12 family. This protein is protease that specifically cleaves Lys-48-linked polyubiquitin chains, and deubiquitinating enzyme associated with the 19S regulatory subunit
  • Synonyms
  • UCHL5; ubiquitin carboxyl-terminal hydrolase L5; ubiquitin carboxyl-terminal hydrolase isozyme L5; CGI 70; INO80 complex subunit R; INO80R; UCH37; ubiquitin thioesterase L5; ubiquitin C-terminal hydrolase UCH37; ubiquitin carboxyl-terminal esterase L5; CG
Cat.#:Uchl5-607MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Uchl5 Protein, His-tagged
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Cat.#:UCHL5-605BTag:His
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine UCHL5 Protein, His-tagged
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Cat.#:UCHL5-1519HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCHL5, His-tagged
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Cat.#:UCHL5-170HTag:His/SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCHL5, His-tagged
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Cat.#:UCHL5-181HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCHL5, GST-tagged
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Cat.#:UCHL5-690HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ubiquitin carboxyl-terminal hydrolase L5, His-tagged
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Cat.#:UCHL5-17781MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UCHL5 Protein
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Cat.#:UCHL5-1668CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UCHL5
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Cat.#:UCHL5-12312ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UCHL5
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Cat.#:UCHL5-533HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UCHL5 293 Cell Lysate
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Involved Pathway

UCHL5 involved in several pathways and played different roles in them. We selected most pathways UCHL5 participated on our site, such as Downregulation of TGF-beta receptor signaling, Signal Transduction, Signaling by TGF-beta Receptor Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCHL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Downregulation of TGF-beta receptor signaling
STUB1; STRAP; PMEPA1; SMAD3B; USP15; UCHL5
Signal Transduction
RPE65A; GAS8; EFCAB7; AES; SOUL3; DNER; SDR16C5; IFT88; ARHGAP17; PRC1
Signaling by TGF-beta Receptor Complex
NEDD8L; STRAP; UCHL5; PMEPA1; TRIM33; SKIA; CGNB; USP9; USP15; SKIB
TGF-beta receptor signaling activates SMADs
NEDD8L; STRAP; UCHL5; NEDD8; PMEPA1; USP15

Protein Function

UCHL5 has several biochemical functions, for example, endopeptidase inhibitor activity, omega peptidase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UCHL5 itself. We selected most functions UCHL5 had, and list some proteins which have the same functions with UCHL5. You can find most of the proteins on our site.
Function
Related Protein
Function endopeptidase inhibitor activity
Related Protein MUG1; SLPI; C3P1; SERPINA1E; SERPINA1D; C3A.6; C3B.2; SPINK2; C3A.2; RENBP
Function omega peptidase activity
Related Protein JOSD1; ATXN3; UCHL5; JOSD2; USP5; UCHL1; APEH; ATXN3L; GGH; USP13
Function poly(A) RNA binding
Related Protein TFRC; PNN; PES1; UTP18; FSCN1; RBM42; EEF1A1; RPS12; RPS21; CDC5L
Function proteasome binding
Related Protein ADRM1; PSMF1; DNAJB2; PSMD14; PSMG1; ID1; USP14; UCHL5; UBD; BAG6
Function protein binding
Related Protein DDO; RIMS1; SETBP1; LAIR2; YWHAG; PDCD6; SPI1; ACTL7A; DEFB121; VPS28
Function ubiquitin-specific protease activity
Related Protein OTUB1B; USP9X; OTUB2; USP19; USP27X; USP8; FAM105B; USP37; DUB1; OTULIN

Interacting Protein

UCHL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCHL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCHL5.
ADRM1

UCHL5 Related Articles

Wang, X; Stafford, W; et al. The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death. MOLECULAR PHARMACOLOGY 85:932-945(2014).
Ouh, IO; Seo, MG; et al. Proteomic Analysis of Testicular Ischemia-Reperfusion Injury in Rats. JOURNAL OF VETERINARY MEDICAL SCIENCE 76:313-321(2014).