UGP2 Protein, UDP-glucose pyrophosphorylase 2


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Official Full Name UDP-glucose pyrophosphorylase 2
Background The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms UGP2; UDP-glucose pyrophosphorylase 2; UTP--glucose-1-phosphate uridylyltransferase; pHC379; UDP glucose diphosphorylase; UDP glucose pyrophosphorylase 2; UDP glucose pyrophosphorylase; UDPG; UDPGP 2; UDPGP; UDPGP2; UGP 1; UGP 2; UGP1; UGPase 2; UGPase; UGPP 2; UGPP2; Uridyl diphosphate glucose pyrophosphorylase 2; UTP glucose 1 phosphate uridyltransferase; UTP glucose 1 phosphate uridylyltransferase 2; OTTHUMP00000159899; OTTHUMP00000214361; OTTHUMP00000214362; OTTHUMP00000214363; UDP-glucose diphosphorylase; UTP-glucose-1-phosphate uridyltransferase; UTP--glucose-1-phosphate uridylyltransferase 2; ur
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGP2-31662TH Recombinant Human UGP2 N/A
    Human UGP2-3585H Recombinant Human UGP2, GST-tagged E.coli GST
    Human UGP2-514HCL Recombinant Human UGP2 293 Cell Lysate HEK293 N/A
    Human UGP2-515HCL Recombinant Human UGP2 293 Cell Lysate HEK293 N/A
    Human UGP2-642H Recombinant Human UDP-glucose pyrophosphorylase 2, His-tagged E.coli His
    Mouse UGP2-17803M Recombinant Mouse UGP2 Protein Mammalian Cell His
    Rhesus Macaque UGP2-5098R Recombinant Rhesus monkey UGP2 Protein, His-tagged Mammalian Cell His
    Chicken UGP2-5687C Recombinant Chicken UGP2 Mammalian Cell His

    UGP2 involved in several pathways and played different roles in them. We selected most pathways UGP2 participated on our site, such as Pentose and glucuronate interconversions, Galactose metabolism, Starch and sucrose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions AKR1B1L; ALDH3A2A; UGP2A; ALDH1B1; Akr1b3; UGT2A1; AKR1B8; XYLB; UGDH; UGT1A3
    Galactose metabolism B4GALT1; AKR1B10; aLA; PGM2; SI; G6PC; HK1; HK3; G6PCA.2; GALE
    Starch and sucrose metabolism PYGB; UGT2A2; UGP2A; UGT1AB; GPIB; TREH; G6PC2; AMY2A5; UGT1A6A; UGP2B
    Amino sugar and nucleotide sugar metabolism CHIA.4; GNPDA1; NANS; GMPPAB; GPIA; GPI; UGP2B; CYB5R2; UAP1; CHIA
    Metabolic pathways UGT2B15; MAPK1IP1L; GPT2; PTGS2; SDHD; SMPD4; TKTB; ADA; SAT2; AMPD3B

    UGP2 has several biochemical functions, for example, UTP:glucose-1-phosphate uridylyltransferase activity, glucose binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGP2 itself. We selected most functions UGP2 had, and list some proteins which have the same functions with UGP2. You can find most of the proteins on our site.

    Function Related Protein
    UTP:glucose-1-phosphate uridylyltransferase activity UGP2A; UGP2B; UGP2
    glucose binding PYGL; HK3; SLC2A3; SLC2A8; UGP2; G6PD; G6PDX; HK2; HK1; GYS1
    identical protein binding TRADD; PFKM; VWA2; TTN; DAPK3; AMELX; PFKL; NEFL; PON2; ACTN2
    metal ion binding CYP2C37; ZNF45; TATDN3; VEZF1B; VPS18; ZIC2; ZDHHC15B; RORCA; ADCY1; ZNF507
    protein binding DUSP2; TSC2; CNTROB; PAWR; OLFM3; COPS7A; TAF1B; VAMP1; FBXO11; EFNA3
    pyrimidine ribonucleotide binding UGP2

    UGP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGP2.

    ARIH2; GLRX3; GRB2; PUF60; CBS; PCBP1; azr; TTN; nickel(2+)

    Tan, GS; Lim, KH; et al. Novel Proteomic Biomarker Panel for Prediction of Aggressive Metastatic Hepatocellular Carcinoma Relapse in Surgically Resectable Patients. JOURNAL OF PROTEOME RESEARCH 13:4833-4846(2014).
    Wang, X; Ju, LG; et al. Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1843:2592-2602(2014).

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