ugp2
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  • Official Full Name
  • UDP-glucose pyrophosphorylase 2
  • Background
  • The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • UGP2; UDP-glucose pyrophosphorylase 2; UTP--glucose-1-phosphate uridylyltransferase; pHC379; UDP glucose diphosphorylase; UDP glucose pyrophosphorylase 2; UDP glucose pyrophosphorylase; UDPG; UDPGP 2; UDPGP; UDPGP2; UGP 1; UGP 2; UGP1; UGPase 2; UGPase; UGPP 2; UGPP2; Uridyl diphosphate glucose pyrophosphorylase 2; UTP glucose 1 phosphate uridyltransferase; UTP glucose 1 phosphate uridylyltransferase 2; OTTHUMP00000159899; OTTHUMP00000214361; OTTHUMP00000214362; OTTHUMP00000214363; UDP-glucose diphosphorylase; UTP-glucose-1-phosphate uridyltransferase; UTP--glucose-1-phosphate uridylyltransferase 2; ur
Cat.#:UGP2-31662THTag:
Source (Host):Species:Human
Product nameRecombinant Human UGP2
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Cat.#:UGP2-3585HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UGP2, GST-tagged
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Cat.#:UGP2-642HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UDP-glucose pyrophosphorylase 2, His-tagged
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Cat.#:UGP2-17803MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UGP2 Protein
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Cat.#:UGP2-5098RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey UGP2 Protein, His-tagged
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Cat.#:UGP2-5687CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UGP2
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Cat.#:UGP2-514HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UGP2 293 Cell Lysate
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Cat.#:UGP2-515HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UGP2 293 Cell Lysate
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Involved Pathway

UGP2 involved in several pathways and played different roles in them. We selected most pathways UGP2 participated on our site, such as Pentose and glucuronate interconversions, Galactose metabolism, Starch and sucrose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pentose and glucuronate interconversions
AKR1A1A; AKR1B1L; DCXR; UGT1A9; UGT1A3; UGT2B15; UGDH; AKR1B10; UGT1A7C; KL
Galactose metabolism
G6PC; GALM; HKDC1; AKR1B1; GLB1; B4GALT2; HK1; AKR1B10; UGP2B; G6PCA.2
Starch and sucrose metabolism
G6PCA.2; AMY2B; AMY2A3; AGL; GYS1; UGT5G1; GPI; UGT1A7; GPIA; UGT1A6B
Amino sugar and nucleotide sugar metabolism
GPI; NAGK; GFPT2; HK1; PGM2; HEXA; CHIT1; AMDHD2; GNPNAT1; PMM1
Metabolic pathways
ATP6V1B1; UGDH; PPCDC; TYMP; AOX1; B3GNT5B; ACSL1; CYP2U1; ACADL; GALNT18

Protein Function

UGP2 has several biochemical functions, for example, UTP:glucose-1-phosphate uridylyltransferase activity, glucose binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGP2 itself. We selected most functions UGP2 had, and list some proteins which have the same functions with UGP2. You can find most of the proteins on our site.
Function
Related Protein
Function UTP:glucose-1-phosphate uridylyltransferase activity
Related Protein UGP2B; UGP2; UGP2A
Function glucose binding
Related Protein UGP2; HK1; HK2; SLC2A8; PYGL; HKDC1; G6PDX; G6PD; GYS1; SLC2A3
Function identical protein binding
Related Protein MIEF1; INS2; SYP; MICALL1; MCIN; COMMD1; TRIP10; ZNF703; VEGFA; PPPDE2
Function metal ion binding
Related Protein CYP2P8; CYP8B2; ZNF567; FIBCD1; RNF220A; RXRBA; ACSM4; COL27A1; EPX; ZFP330
Function protein binding
Related Protein IRS2; IL6R; SP100; PUM1; PKD2L1; VPS28; IRF3; APOA1BP; PRAM1; ISOC1
Function pyrimidine ribonucleotide binding
Related Protein UGP2

Interacting Protein

UGP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGP2.
ARIH2; GLRX3; GRB2; PUF60; CBS; PCBP1; azr; TTN; nickel(2+)

UGP2 Related Articles

Tan, GS; Lim, KH; et al. Novel Proteomic Biomarker Panel for Prediction of Aggressive Metastatic Hepatocellular Carcinoma Relapse in Surgically Resectable Patients. JOURNAL OF PROTEOME RESEARCH 13:4833-4846(2014).
Wang, X; Ju, LG; et al. Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1843:2592-2602(2014).