ugt2b7
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  • Official Full Name
  • UDP glucuronosyltransferase 2 family, polypeptide B7
  • Background
  • The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites.
  • Synonyms
  • UGT2B7; UDP glucuronosyltransferase 2 family, polypeptide B7; UDP glycosyltransferase 2 family, polypeptide B7; UDP-glucuronosyltransferase 2B7; UGT2B9; 3 4 catechol estrogen specific; UDP glucuronosyltransferase 2 family polypeptide B7; UDP glucuronosyltransferase 2B7; UDP glucuronyltransferase family 2 beta 7; UDP glycosyltransferase 2 family polypeptide B7; UDPGT; UDPGTh 2; UDPGTh2; UGTB2B9; UDPGTh-2; UDPGT 2B7; 3,4-catechol estrogen specific; UDP-glucuronosyltransferase 2B9; 3,4-catechol estrogen-specific UDPGT; UDP-glucuronyltransferase, family 2, beta-7; UDPGT2B7; UDPGT 2B9
Cat.#:Ugt2b7-604RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ugt2b7 Protein, His-tagged
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Cat.#:UGT2B7-209HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human UGT2B7, GST-tagged
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Cat.#:UGT2B7-6436RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UGT2B7 Protein
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Involved Pathway

UGT2B7 involved in several pathways and played different roles in them. We selected most pathways UGT2B7 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT2B7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pentose and glucuronate interconversions
UGT1A6; AKR1B1L; UGP2A; UGT2A3; DCXR; AKR1B1; XYLB; UGT1A3; AKR1B7; UGT1A2
Ascorbate and aldarate metabolism
UGT2B7; UGT1A6B; UGT1A6; UGT1A2; UGT2A3; ALDH9A1A.1; UGT5G1; ALDH9A1; ALDH7A1; GKUP
Steroid hormone biosynthesis
HSD17B7; SRD5A2; UGT1A7; UGT1A1; CYP2C54; UGT2A1; HSD3B5; UGT2A3; CYP11C1; CYP2D9
Starch and sucrose metabolism
PYGM; G6PCA.1; GANC; GPI; AMY1A; PYGB; AMY2A4; Amy1; GBA3; AMY2A
Retinol metabolism
DGAT1A; RDH10; CYP3A65; RDH10A; ADH2-1; CYP3A25; DHRS9; RPE65; CYP3A7-CYP3AP1; ADH2-2
Porphyrin and chlorophyll metabolism
HMOX2; UROS; UGT1A6; COX10; UGT1A6B; UGT5G1; UGT1AB; UGT1A7; GUSB; UGT1A9
Metabolism of xenobiotics by cytochrome P
GSTM7; GSTA1; GSTM3; UGT1A3; UGT1A6A; GSTT1; UGT1A1; ALDH3B1; GSTA3; CBR1
Drug metabolism - cytochrome P
GSTM5; MGST3; GSTT1; UGT5G1; MAOB; UGT2B7; UGT1A9; GSTA3; GSTT2B; UGT1A3
Drug metabolism - other enzymes
UPB1; TYMP; CDA; GUSB; UPP2; PNAT10; CES2; UGT1A3; UGT2A1; UCK2
Metabolic pathways
ALPI.1; CAD; ackA; ITPK1A; SPR; PTGS2B; GLUL; GANC; PKMA; PAH
Chemical carcinogenesis
CCBL2; CYP2E1; Nat3; ARNT; CYP3A25; ADH1; GSTM3; CYP2B19; SULT2A1; UGT2A1

Protein Function

UGT2B7 has several biochemical functions, for example, glucuronosyltransferase activity, NOT retinoic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT2B7 itself. We selected most functions UGT2B7 had, and list some proteins which have the same functions with UGT2B7. You can find most of the proteins on our site.
Function
Related Protein
Function glucuronosyltransferase activity
Related Protein UGT1B1; UGT2B15; UGT1B5; UGT1A7C; UGT2A6; UGT5E1; UGT2B6; UGT2A1; UGT5A2; UGT3A1
Function NOT retinoic acid binding
Related Protein UGT1A6; UGT2B15; UGT1A4; UGT2B7

Interacting Protein

UGT2B7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT2B7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT2B7.
GABRA3

UGT2B7 Related Articles

Fujiwara, R; Itoh, T; et al. Extensive Protein-Protein Interactions Involving UDP-glucuronosyltransferase (UGT) 2B7 in Human Liver Microsomes. DRUG METABOLISM AND PHARMACOKINETICS 29:259-265(2014).
Pazik, J; Oldak, M; et al. Uridine Diphosphate Glucuronosyltransferase 2B7 Variant p.His268Tyr as a Predictor of Kidney Allograft Early Acute Rejection. TRANSPLANTATION PROCEEDINGS 45:1516-1519(2013).