UGT2B7 Protein, UDP glucuronosyltransferase 2 family, polypeptide B7

UGT2B7

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UGT2B7

Official Full Name UDP glucuronosyltransferase 2 family, polypeptide B7
Background The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites.
Synonyms UGT2B7; UDP glucuronosyltransferase 2 family, polypeptide B7; UDP glycosyltransferase 2 family, polypeptide B7; UDP-glucuronosyltransferase 2B7; UGT2B9; 3 4 catechol estrogen specific; UDP glucuronosyltransferase 2 family polypeptide B7; UDP glucuronosyltransferase 2B7; UDP glucuronyltransferase family 2 beta 7; UDP glycosyltransferase 2 family polypeptide B7; UDPGT; UDPGTh 2; UDPGTh2; UGTB2B9; UDPGTh-2; UDPGT 2B7; 3,4-catechol estrogen specific; UDP-glucuronosyltransferase 2B9; 3,4-catechol estrogen-specific UDPGT; UDP-glucuronyltransferase, family 2, beta-7; UDPGT2B7; UDPGT 2B9
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT2B7-209H Recombinant Human UGT2B7, GST-tagged Wheat Germ GST
    Rat Ugt2b7-604R Recombinant Rat Ugt2b7 Protein, His-tagged E.coli His
    Rat UGT2B7-6436R Recombinant Rat UGT2B7 Protein Mammalian Cell His

    UGT2B7 involved in several pathways and played different roles in them. We selected most pathways UGT2B7 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT2B7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions UGT1A7; ALDH3A2A; AKR1B1L; DHDH; UGT1A6B; UGT1A2; UGT2A1; XYLB; UGT2A3; UGT2B7
    Ascorbate and aldarate metabolism ALDH9A1A.1; MIOX; GKUP; UGT1A3; ALDH9A1B; ALDH3A2A; UGT1A9; UGT1A6B; UGT1A7C; UGT1A7
    Steroid hormone biosynthesis CYP2C39; SRD5A1; UGT1A7; COMTB; UGT1A6; UGT1A9; UGT1A6B; CYP3A7-CYP3AP1; HSD17B7; HSD11B2
    Starch and sucrose metabolism GBE1; G6PCA.2; UGP2B; AMY2A3; AMY2B; HKDC1; PGM2L1; PYGL; AMY1B; SI
    Retinol metabolism ADH2-2; CYP3A7; UGT2B7; HSD17B6; SDR16C5A; CYP1A; DHRS4; UGT1A4; UGT1A3; UGT1A2
    Porphyrin and chlorophyll metabolism CP; UROD; UGT2B7; HMBSB; UGT1A3; HMOX1A; FXN; GUSB; HCCSA.1; ALAD
    Metabolism of xenobiotics by cytochrome P GSTA5; GSTA1; AKR7A3; MGST2; GSTM; UGT1A6A; UGT1A1; UGT1A9; CYP1A; UGT2B7
    Drug metabolism - cytochrome P UGT1A4; GSTA; UGT1A2; GSTA4; GSTM3; UGT2B7; GSTP1; AOX4; FMO1; MGST1
    Drug metabolism - other enzymes DPYDB; UGT1AB; UCK1; CES1; UGT5G1; UPP1; CES1D; UGT1A2; GUSB; NAT2
    Metabolic pathways UGT1A9; PLA2G2E; GALNTL6; ADH6; CYP4F2; GGT5A; ADH1C; ACSL1A; IDO2; MTMR7B
    Chemical carcinogenesis EPHX1; UGT1A6A; CYP3A25; CHRNA7; UGT1A4; UGT1A9; UGT1A6B; CYP3A4; CYP3A7; GSTT2

    UGT2B7 has several biochemical functions, for example, glucuronosyltransferase activity, NOT retinoic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT2B7 itself. We selected most functions UGT2B7 had, and list some proteins which have the same functions with UGT2B7. You can find most of the proteins on our site.

    Function Related Protein
    glucuronosyltransferase activity GYLTL1B; UGT5A5; UGT1A7C; UGT1AB; UGT2B6; UGT2A6; UGT5B3; UGT5A4; UGT2B3; UGT2A1
    NOT retinoic acid binding UGT2B15; UGT1A4; UGT1A6; UGT2B7

    UGT2B7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT2B7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT2B7.

    GABRA3

    Fujiwara, R; Itoh, T; et al. Extensive Protein-Protein Interactions Involving UDP-glucuronosyltransferase (UGT) 2B7 in Human Liver Microsomes. DRUG METABOLISM AND PHARMACOKINETICS 29:259-265(2014).
    Pazik, J; Oldak, M; et al. Uridine Diphosphate Glucuronosyltransferase 2B7 Variant p.His268Tyr as a Predictor of Kidney Allograft Early Acute Rejection. TRANSPLANTATION PROCEEDINGS 45:1516-1519(2013).

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