UHRF1 Protein, ubiquitin-like, containing PHD and RING finger domains, 1

UHRF1

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UHRF1

Official Full Name ubiquitin-like, containing PHD and RING finger domains, 1
Background DNA methylation inheritance is the process of copying pre-existing methylation patterns onto newly replicated DNA strand after DNA replication. Dnmt1 is the DNA methyltransferase that methylate hemi-methylated CpG region, which occurs after DNA repairs an
Synonyms UHRF1; ubiquitin-like, containing PHD and RING finger domains, 1; E3 ubiquitin-protein ligase UHRF1; nuclear protein 95; nuclear zinc finger protein Np95; ubiquitin-like PHD and RING finger domain-containing protein 1; ubiquitin-like-containing PHD and RI
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UHRF1-233H Recombinant Human UHRF1 Protein, GST-tagged E.coli GST
    Human UHRF1-234H Recombinant Human UHRF1 Protein, His-tagged E.coli His
    Human UHRF1-235H Recombinant Human UHRF1 Protein, GST-tagged E.coli GST
    Human UHRF1-236H Recombinant Human UHRF1 Protein, His-tagged E.coli His
    Human UHRF1-237H Recombinant Human UHRF1 Protein, GST-tagged E.coli GST
    Human UHRF1-238H Recombinant Human UHRF1 Protein, His-tagged E.coli His
    Human UHRF1-239H Recombinant Human UHRF1 Protein, GST-tagged E.coli GST
    Human UHRF1-241H Recombinant Human UHRF1 Protein, His-tagged E.coli His
    Human UHRF1-242H Recombinant Human UHRF1 Protein, GST-tagged E.coli GST
    Human UHRF1-243H Recombinant Human UHRF1 Protein, His-tagged E.coli His
    Human UHRF1-31665TH Recombinant Human UHRF1 Wheat Germ N/A
    Human UHRF1-508HCL Recombinant Human UHRF1 293 Cell Lysate HEK293 N/A
    Mouse UHRF1-17826M Recombinant Mouse UHRF1 Protein Mammalian Cell His
    Rat UHRF1-6439R Recombinant Rat UHRF1 Protein Mammalian Cell His
    Zebrafish UHRF1-12306Z Recombinant Zebrafish UHRF1 Mammalian Cell His

    UHRF1 involved in several pathways and played different roles in them. We selected most pathways UHRF1 participated on our site, such as DNA methylation, Epigenetic regulation of gene expression, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with UHRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DNA methylation DNMT3B; DNMT3L; DNMT1; DNMT3A; UHRF1
    Epigenetic regulation of gene expression UHRF1; H3F3D; BAZ2A; DNMT3L; RBB4L; TAF1A; DNMT3B; EED; MTF2; JARID2B
    Gene Expression ZNF215; TRMT5; PRDM7; COX14; ZNF266; ZFP36L1; YAP1; TACO1; LRPPRC; SIN3B

    UHRF1 has several biochemical functions, for example, core promoter proximal region sequence-specific DNA binding, hemi-methylated DNA-binding, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UHRF1 itself. We selected most functions UHRF1 had, and list some proteins which have the same functions with UHRF1. You can find most of the proteins on our site.

    Function Related Protein
    core promoter proximal region sequence-specific DNA binding CXXC1; MEF2C; SP3A; DMRTA1; GATA3; DMRTC1B; UHRF1; DMRT2; PAX2; DMRTC2
    hemi-methylated DNA-binding UHRF1
    histone binding NASP; HIST1H3C; ASF1B; USP49; NOC2L; RCC1; MYSM1; HIST1H4D; PRMT6; CTSL2
    identical protein binding PTPRM; TP53; ST13; ROBO1; MAP1S; SOD1; FAM108A1; AGXT2L2; KCNIP2; APLP1
    ligase activity MYLIPB; MKRN1; TRAF2; MARCH2; HERC6; RNF14; RNF182; RBBP6; SMURF1; LTN1
    methyl-CpG binding ZNF295; MBD1B; LRWD1; MBD3; MBD1; MBD3L1; MECP2; MBD3A; UHRF1; ZBTB4
    methylated histone binding CBX4; RBBP5; LOXL2; CAPNS2; ATRX; CBX8; FAM156A; SUZ12; KAT8; LRWD1
    nucleosomal histone binding L3MBTL1; UHRF1; VRK1
    protein binding TP53RK; SUMO1; CASR; CASP10; PARVA; EGR1; SOX10; GPR128; ALX1; PTK2B
    transcription factor activity, sequence-specific DNA binding DMRT2B; NTNG1; PA2G4; ZHX2; ELK1; SIX2; POU5F2; TBX2B; PLAGL2; HOXB8A
    ubiquitin protein ligase activity UBR2; RNF149; UBE2NB; RAD18; ANKIB1; RNF180; PRPF19; NEDD4L; UBR5; MDM2
    ubiquitin-protein transferase activity NLRC4; RNF187; HUWE1; CMTM2A; RNF220; ITCHA; HECTD3; WWP1; TOPORS; RNF38
    zinc ion binding BRD1B; LONRF2; KAT6A; BRD1; TRPS1; FHL3B; AQPEP; MECR; BMP1A; MARCH10

    UHRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UHRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UHRF1.

    DNMT1; DNMT3B; DNMT3A

    Marjoram, L; Alvers, A; et al. Epigenetic control of intestinal barrier function and inflammation in zebrafish. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:2770-2775(2015).
    Jung, YD; Shim, JW; et al. Downregulation of UHRF1 promotes EMT via inducing CXCR4 in human cancer cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1232-1242(2015).

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