This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.
UNC119; unc-119 homolog (C. elegans); unc119 (C.elegans) homolog; protein unc-119 homolog A; HRG4; POC7; POC7 centriolar protein homolog A (Chlamydomonas); POC7A; Cone-rod dystrophy, included; Human retinal gene 4; MRG4; Protein unc 119 homolog A; Retinal protein 4; RG4; RRG4; Rtg4; unc 119 homolog (C. elegans); Unc 119 protein homolog; Unc119h; Uncl19; OTTHUMP00000163438; OTTHUMP00000163439; OTTHUMP00000163440; POC7 centriolar protein homolog A
UNC119 involved in several pathways and played different roles in them. We selected most pathways UNC119 participated on our site, such as IL-5 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC119 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Related Protein
IL-5 Signaling Pathway
SDCBP; GSK3AB; UNC119; ALOX5AP
UNC119 has several biochemical functions, for example, lipid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC119 itself. We selected most functions UNC119 had, and list some proteins which have the same functions with UNC119. You can find most of the proteins on our site.
Function lipid binding
Related Protein PITPNM3; FAM123B; PLTP; RASGRP1; PACSIN1B; PTGS1; BAD; PFN4; PLEKHA2; FFAR3
Function protein binding
Related Protein TNPO2; BNIP3L; HIST2H4; APLF; TMEM110; INO80E; RBM14; MSH5; TP73; FAM83A
UNC119 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC119 here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC119.