unc13d
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  • Official Full Name
  • unc-13 homolog D
  • Background
  • This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
  • Synonyms
  • UNC13D; unc-13 homolog D (C. elegans); protein unc-13 homolog D; Munc13 4; FHL3; HLH3; HPLH3; Munc13-4
Cat.#:UNC13D-28544THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UNC13D, His-tagged
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Cat.#:UNC13D-17843MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UNC13D Protein
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Cat.#:UNC13D-6447RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UNC13D Protein
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Cat.#:UNC13D-501HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UNC13D 293 Cell Lysate
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Involved Pathway

UNC13D involved in several pathways and played different roles in them. We selected most pathways UNC13D participated on our site, such as Deregulation of Rab and Rab Effector Genes in Bladder Cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC13D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Deregulation of Rab and Rab Effector Genes in Bladder Cancer
SYTL2; SYTL3; MYRIP; GCC2; TBC1D10A; RAB27A; UNC13D; RPH3AL; SYTL1; EXPH5

Protein Function

UNC13D has several biochemical functions, for example, Rab GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC13D itself. We selected most functions UNC13D had, and list some proteins which have the same functions with UNC13D. You can find most of the proteins on our site.
Function
Related Protein
Function Rab GTPase binding
Related Protein ODF2; NDRG1; TBC1D20; SYTL2; ERC1; CCDC64; GAS8; RABGGTA; HPS6; STXBP5L
Function protein binding
Related Protein MYD88; THBS2; BDKRB2; ASAP3; WRN; FAIM; ETV5; BCL2L14; OSTB; ANKRD24