whsc1l1
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  • Official Full Name
  • Wolf-Hirschhorn syndrome candidate 1-like 1
  • Background
  • This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.
  • Synonyms
  • WHSC1L1; Wolf-Hirschhorn syndrome candidate 1-like 1; histone-lysine N-methyltransferase NSD3; FLJ20353; NSD3; DKFZp667H044; Histone lysine N methyltransferase NSD3; MGC126766; MGC142029; NSD 3; Nuclear set domain containing 3; Nuclear SET domain containing protein 3; pp14328; Whistle; WHSC1 like protein 1; WHSC1L1 protein; Wolf Hirschhorn syndrome candidate 1 like 1; protein whistle; OTTHUMP00000228478; OTTHUMP00000228479; OTTHUMP00000228480; OTTHUMP00000228487; WHSC1-like protein 1; nuclear SET domain-containing protein 3; WHSC1-like 1 isoform 9 with methyltransferase activity to lysi
Cat.#:WHSC1L1-2631HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human WHSC1L1 Protein (1-645 aa), His-tagged
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Cat.#:WHSC1L1-148HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WHSC1L1 Protein, GST-tagged
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Cat.#:WHSC1L1-186HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WHSC1L1 protein, GST-tagged
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Cat.#:WHSC1L1-28412THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WHSC1L1, His-tagged
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Cat.#:WHSC1L1-3729HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WHSC1L1, GST-tagged
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Cat.#:WHSC1L1-18546MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse WHSC1L1 Protein
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Cat.#:WHSC1L1-313HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human WHSC1L1 293 Cell Lysate
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Cat.#:WHSC1L1-314HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human WHSC1L1 293 Cell Lysate
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Involved Pathway

WHSC1L1 involved in several pathways and played different roles in them. We selected most pathways WHSC1L1 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with WHSC1L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Lysine degradation
BBOX1; SUV420H1; ALDH2; PIPOX; WHSC1; AADAT; KMT2E; SETD7; AGXT2L2; SUV39H2

Protein Function

WHSC1L1 has several biochemical functions, for example, histone methyltransferase activity (H3-K27 specific), histone methyltransferase activity (H3-K4 specific), histone-lysine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WHSC1L1 itself. We selected most functions WHSC1L1 had, and list some proteins which have the same functions with WHSC1L1. You can find most of the proteins on our site.
Function
Related Protein
Function histone methyltransferase activity (H3-K27 specific)
Related Protein EZH2; WHSC1L1; EHMT2; EHMT1
Function histone methyltransferase activity (H3-K4 specific)
Related Protein KMT2A; SMYD1B; WDR82; SETD3; MLL1; SETMAR; WHSC1L1; KMT2E; WBP7; MLL5
Function histone-lysine N-methyltransferase activity
Related Protein SUV39H1B; WHSC1L1; SETD2; SMYD1; PRDM6; SETD8A; SETD8B; KMT2A; EHMT1A; EHMT2
Function protein binding
Related Protein ELK4; RUNDC3A; STAT3; CHEK1; LOH12CR1; DUSP15; NSG1; MCM2; DDIT3; FNBP1
Function zinc ion binding
Related Protein DIDO1; Car12; ZFP622; NPSN; APOBEC2; PRKCB; MYLIPA; CDADC1; ADAM19; CTCF

Interacting Protein

WHSC1L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WHSC1L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WHSC1L1.
MLLT6; HEL25; RAD51; SLU7; HOXC4; MNDA; ATM; DAXX