wnt1
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  • Official Full Name
  • wingless-type MMTV integration site family, member 1
  • Background
  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
  • Synonyms
  • WNT1; wingless-type MMTV integration site family, member 1; INT1; OI15; BMND16; proto-oncogene Wnt-1; proto-oncogene Int-1 homolog; wingless-type MMTV integration site family, member 1 (oncogene INT1)
Cat.#:Wnt1-001MTag:N/A
Source (Host):CHO CellSpecies:Mouse
Product nameRecombinant Mouse Wnt-1/sFRP-1 Complex Protein
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Cat.#:WNT1-204HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human WNT1, StrepII-tagged
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Cat.#:WNT1-31526THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WNT1
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Cat.#:WNT1-560HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WNT1
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Cat.#:WNT1-18563MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse WNT1 Protein
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Cat.#:WNT1-7923ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish WNT1
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Cat.#:WNT1-304HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human WNT1 293 Cell Lysate
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Involved Pathway

WNT1 involved in several pathways and played different roles in them. We selected most pathways WNT1 participated on our site, such as Wnt signaling pathway, Hedgehog signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
WIF1; CER1; GPC4; FZD7; MAPK8A; PRKACBA; CCND2A; PRKACB; EP300; RHOA
Hedgehog signaling pathway
STK36; IHHB; CSNK1DB; WNT7B; FBXW11; SKI; ZIC2A; WNT4A; ZIC2B; WNT9A
Hippo signaling pathway
LEF1; PPP2CB; NKD1; BMPR1A; GDF7; GLI2; BMP7; WNT3; BIRC2; TEAD1
Signaling pathways regulating pluripotency of stem cells
ACVR2B; PIK3R1; PIK3CA; ONECUT1; INHBE; BMPR1B; NRAS; HESX1; SMAD4; OTX1
Melanogenesis
Kitl; PLCB2; MAP2K2; MITFA; GNAI1; CALM; a; CAMK2D2; FZD8B; RAF1A
HTLV-I infection
SLC25A31; PTTG2; ITGAL; FZD2; IL15RA; MSX1; FZD7; CCNB2; NFATC2; FZD8
Pathways in cancer
GNAS; FASLG; RAC3; HIF1A; FGF7; ITGA2B; VEGFC; RHOA; Fgf15; IL6
Proteoglycans in cancer
RAF1; HGF; TIMP3; SDC1; PTK2; FGF2; ITGB1; CAMK2G; PAK1; PLCG1
Basal cell carcinoma
SMO; AXIN1; WNT11; PTCH2; GLI1; WNT10B; WNT7A; TRP53; SETD6; WNT3A

Protein Function

WNT1 has several biochemical functions, for example, cytokine activity, frizzled binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT1 itself. We selected most functions WNT1 had, and list some proteins which have the same functions with WNT1. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein Fasl; MIF; TGFB1; IFNA2; IFNA12; IL23; IL17A/F2; CMTM4; CMTM2; Il1f6
Function frizzled binding
Related Protein WNT9B; SDCBP; SFRP1; WNT1; WNT5A; NDP; DVL1B; WNT10B; WNT9A; WNT8A
Function protein domain specific binding
Related Protein CALM2; SP100; ICAL1; AKAP1; AKAP5; GABRR1; PRKAR2B; HSPA5; Ar; KCTD13
Function receptor agonist activity
Related Protein VEGFA; WNT8A; SFRP2; WNT2; NODAL; WNT3A; WNT1; CXCL13; WNT5A; WNT10B
Function transcription regulatory region DNA binding
Related Protein GATA6; HNRNPL; BASP1; FOS; ATF3; FOXM1; ATMIN; TFAP2A; RBBP5; RREB1

WNT1 Related Articles

Jing, D; Cai, J; et al. Pulsed Electromagnetic Fields Partially Preserve Bone Mass, Microarchitecture, and Strength by Promoting Bone Formation in Hindlimb-Suspended Rats. JOURNAL OF BONE AND MINERAL RESEARCH 29:2250-2261(2014).
Tsai, HL; Deng, WP; et al. Wnts Enhance Neurotrophin-Induced Neuronal Differentiation in Adult Bone-Marrow-Derived Mesenchymal Stem Cells via Canonical and Noncanonical Signaling Pathways. PLOS ONE 9:-(2014).

WNT1 Related Gene Family

WNT