Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

WNT1

  • Official Full Name

    wingless-type MMTV integration site family, member 1

  • Overview

    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
  • Synonyms

    WNT1; wingless-type MMTV integration site family, member 1; INT1; OI15; BMND16; proto-oncogene Wnt-1; proto-oncogene Int-1 homolog; wingless-type MMTV integration site family, member 1 (oncogene INT1);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO Cell
  • E. coli
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • GST
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WNT1-204H Recombinant Human WNT1, StrepII-tagged Human Cell Strep II 28-370, 343 a.a.
Human WNT1-560H Recombinant Human WNT1 E.coli N/A
Human WNT1-304HCL Recombinant Human WNT1 293 Cell Lysate HEK293 N/A
Human WNT1-581H Recombinant Human WNT1 Protein, His&GST-tagged E.coli N-His&GST Ala28-Leu370
Human WNT1-110H Recombinant Human WNT1 Protein E. coli
Mouse WNT1-18563M Recombinant Mouse WNT1 Protein Mammalian Cell His
Mouse WNT1-10190M Recombinant Mouse WNT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Wnt1-5875M Recombinant Mouse Wnt1 protein, His&Myc-tagged E.coli His&Myc 28-370aa
Mouse WNT1-10190M-B Recombinant Mouse WNT1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Wnt1-001M Active Recombinant Mouse Wnt-1/sFRP-1 Complex Protein CHO Cell N/A
Rat WNT1-3402R Recombinant Rat WNT1 protein, His-GST-tagged E.coli His/GST Ala28~Leu370
Zebrafish WNT1-7923Z Recombinant Zebrafish WNT1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • WNT1 Related Articles
  • WNT1 Related Gene Family
  • WNT1 Related Signal Pathway

WNT1 involved in several pathways and played different roles in them. We selected most pathways WNT1 participated on our site, such as Wnt signaling pathway, Hedgehog signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwayPLCB3;FZD8;RAC1A;MYCB;FZD3;RAC3;SMAD4;RAC3B;SIAH1A
Hedgehog signaling pathwayGSK3AA;PTCH1;WNT2;WNT11B;CSNK1DB;PRKACAB;WNT10B;CSNK1A1L;WNT2BB
Hippo signaling pathwayWNT8A;FZD7;PPP1CB;AFP;BTRC;PARD3;DLG1;PPP2CA;CDH1
Signaling pathways regulating pluripotency of stem cellsSMAD4;PCGF6;IL6ST;KRAS;POU5F1;ACVR2A;HOXB1;ACVR2B;OTX1
MelanogenesisGNAS;GNAIA;GNAQ;CAMK2G;RAF1;PRKACG;EDNRBA;FZD7B;PRKCBA
HTLV-I infectionPRKACG;CD3E;CDC23;BCL2L1;PTTG2;LCK;PPP3R2;ATF1;NFATC4
Pathways in cancerPLCG2;Fasl;FGF5;GNB2;WNT6;BAX;RALB;PTEN;MAX
Proteoglycans in cancerITGA5;RPS6KB1;PRKACG;RRAS2;MAP2K2;FAS;ERBB2;WNT5A;MAPK13
Basal cell carcinomaTCF7;WNT3A;TCF7L2;WNT16;SMO;FZD7;WNT5B;FZD9;FZD6

WNT1 has several biochemical functions, for example, cytokine activity, frizzled binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT1 itself. We selected most functions WNT1 had, and list some proteins which have the same functions with WNT1. You can find most of the proteins on our site.

Function Related Protein
cytokine activityCcl9;GDF3;IL17A/F1;CSF1B;CCL20B;MSTNB;Il1f9;TNFSF18;IL12BA
frizzled bindingWNT16;WNT1;WNT2B;RSPO3;WNT8A;DVL3;ZNRF3;WNT4B;WNT5B
protein domain specific bindingIGBP1;CA;MYH9;LAMP1;MLF1;ARFIP2A;CALM3;PKD1;IPCEF1
receptor agonist activityWNT3;SFRP2;WNT10B;VEGFA;WNT1;GREM1;WNT2;WNT5A;WNT3A
transcription regulatory region DNA bindingSALL1;DDIT3;FOS;SOX6;SOX7;YY1;IKZF1;RCOR1;IKZF2

WNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT1.

Jing, D; Cai, J; et al. Pulsed Electromagnetic Fields Partially Preserve Bone Mass, Microarchitecture, and Strength by Promoting Bone Formation in Hindlimb-Suspended Rats. JOURNAL OF BONE AND MINERAL RESEARCH 29:2250-2261(2014).
Tsai, HL; Deng, WP; et al. Wnts Enhance Neurotrophin-Induced Neuronal Differentiation in Adult Bone-Marrow-Derived Mesenchymal Stem Cells via Canonical and Noncanonical Signaling Pathways. PLOS ONE 9:-(2014).
WNT
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can WNT1 be used as a diagnostic marker for certain cancers? 07/04/2022

Research suggests that elevated levels of WNT1 may serve as a diagnostic marker for certain cancers, aiding in early detection.

Are there therapeutic interventions targeting WNT1 for neurodegenerative diseases? 02/15/2020

Some studies are exploring the modulation of WNT1 signaling as a potential therapeutic approach for neurodegenerative diseases.

Is WNT1 involved in bone formation and regeneration? 12/11/2019

Yes, WNT1 plays a crucial role in bone development and regeneration, and its manipulation is being explored for potential applications in bone-related disorders.

Are there any ongoing clinical trials targeting WNT1 in cancer treatment? 08/29/2018

Yes, some clinical trials are exploring the inhibition of WNT1 as a potential strategy for treating specific types of cancers.

How does WNT1 relate to neurodegenerative diseases? 05/21/2016

WNT1 has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's, where its dysregulation may contribute to the pathology.

Customer Reviews (3)

Write a review
Reviews
10/10/2020

    The manufacturer's commitment to providing high-quality proteins is evident in their meticulous production process, ensuring the purity and reliability of the WNT1 protein.

    10/25/2019

      The WNT1 protein is characterized by its exceptional quality, making it an ideal choice to fulfill my experimental requirements.

      05/07/2017

        the WNT1 protein's high quality and its compatibility with my experimental needs, coupled with the manufacturer's excellent technical support, create a valuable alliance that contributes to successful research endeavors.

        Ask a Question for All WNT1 Products

        Required fields are marked with *

        My Review for All WNT1 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends