wnt1
Share
  • Official Full Name
  • wingless-type MMTV integration site family, member 1
  • Background
  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
  • Synonyms
  • WNT1; wingless-type MMTV integration site family, member 1; INT1; OI15; BMND16; proto-oncogene Wnt-1; proto-oncogene Int-1 homolog; wingless-type MMTV integration site family, member 1 (oncogene INT1)
Cat.#:WNT1-204HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human WNT1, StrepII-tagged
+Inquiry
Cat.#:WNT1-31526THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WNT1
+Inquiry
Cat.#:WNT1-560HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WNT1
+Inquiry
Cat.#:WNT1-18563MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse WNT1 Protein
+Inquiry
Cat.#:WNT1-7923ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish WNT1
+Inquiry
Cat.#:WNT1-304HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human WNT1 293 Cell Lysate
+Inquiry

Involved Pathway

WNT1 involved in several pathways and played different roles in them. We selected most pathways WNT1 participated on our site, such as Wnt signaling pathway, Hedgehog signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
SFRP2; PPP3R1B; WNT7AA; SIAH1A; PRKACG; DKK1; MMP7; WIF1; RBX1; TCF7
Hedgehog signaling pathway
Shh; ZIC2B; PRKACB; ZIC2; RAB23; WNT8B; WNT3A; GLI2A; WNT10B; WNT3
Hippo signaling pathway
YWHAZ; WNT11; CRB2; BMP8A; INADL; MPP5; BMP5; BIRC2; SERPINE1; GLI2
Signaling pathways regulating pluripotency of stem cells
SMAD3; REST; WNT10B; APC; ONECUT1; GSK3B; ZFHX3; WNT8B; PCGF1; WNT5B
Melanogenesis
HRASB; FZD3A; GNAQ; FZD5; ASIP; KIT; MITFB; DVL3A; FZD1; CALML3
HTLV-I infection
ZFP36; CDC23; RRAS; KRAS; LTBR; PPP3R2; CDC27; POLE; CREM; HLA-B
Pathways in cancer
RAC2; CDH1; CBLC; TPR; PIK3CG; NKX3-1; FGF18; CASP9; GNG7; NOS2
Proteoglycans in cancer
WNT6; CBLC; WNT7A; FZD2; FLNC; PPP1CC; WNT7B; PRKCB; MAPK3; CAV3
Basal cell carcinoma
FZD6; WNT7B; WNT5A; WNT2B; AXIN1; BMP4; TCF7L2; WNT3; WNT6; SMO

Protein Function

WNT1 has several biochemical functions, for example, cytokine activity, frizzled binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT1 itself. We selected most functions WNT1 had, and list some proteins which have the same functions with WNT1. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein IL1RN; VEGFA; TNFB; Fasl; CSF1A; CD40LG; CSF3; TNFSF10; Il23a; Il12b; IL8L2
Function frizzled binding
Related Protein WNT5A; WNT2B; ROR2; FZD1; WNT2BB; DVL3; WNT2; DVL3A; WNT6; WNT16
Function protein domain specific binding
Related Protein DDX20; FOXA2; GABRR2; ARR3; ZBTB16; SKIL; GNAI3; YWHAE; NEFL; E2F4
Function receptor agonist activity
Related Protein WNT5A; WNT4; WNT10B; WNT3A; WNT2; CXCL13; GREM1; NODAL; GAS6; WNT3
Function transcription regulatory region DNA binding
Related Protein GABPB2; SMARCA2; KLF4; LEF1; WT1; MTERFD3; SOX7; EGR2; PRDM5; TBX21

WNT1 Related Articles

Jing, D; Cai, J; et al. Pulsed Electromagnetic Fields Partially Preserve Bone Mass, Microarchitecture, and Strength by Promoting Bone Formation in Hindlimb-Suspended Rats. JOURNAL OF BONE AND MINERAL RESEARCH 29:2250-2261(2014).
Tsai, HL; Deng, WP; et al. Wnts Enhance Neurotrophin-Induced Neuronal Differentiation in Adult Bone-Marrow-Derived Mesenchymal Stem Cells via Canonical and Noncanonical Signaling Pathways. PLOS ONE 9:-(2014).

WNT1 Related Gene Family

WNT