WNT16

  • Official Full Name

    wingless-type MMTV integration site family, member 16

  • Overview

    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5 termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]

  • Synonyms

    WNT16;wingless-type MMTV integration site family, member 16;protein Wnt-16;wingless-type MMTV integration site family member 16b

Recombinant Proteins

  • Zebrafish
  • Human
  • Mouse
  • Mammalian Cells
  • HEK293
  • E.coli
  • E. coli
  • His
  • Non
  • Flag
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    WNT16 involved in several pathways and played different roles in them. We selected most pathways WNT16 participated on our site, such as Wnt signaling pathway,Hedgehog signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pathways in cancer Kitl,Fasl,RAC2,TRAF6,ITGA3,ARNT,FGF6,MAPK8,TGFB2,RBX1
    Transcriptional misregulation in cancer ID2,FOXO1,MLLT1,MMP9,PLAT,HOXA9,MMP3,PAX7,HPGD,FLI1
    Hippo signaling pathway NKD1,CTGF,WNT8B,CDH1,PPP2CA,FZD8,WNT3,MPP5,CCND1,APC
    Melanogenesis Adcy4,CALML3,FZD10,WNT2BA,CALM1B,TYRP1,DVL1B,FZD9,GSK3AA,CALM1A
    Wnt signaling pathway TBL1X,WIF1,PPP3R1,CAMK2B1,MAP3K7,LEF1,FOSL1,FZD8,PRKACAB,WNT5B
    HTLV-I infection NFATC1,WNT11,TSPO,GSK3B,WNT8A,FDPS,ATM,WNT8B,ITGB2,FOSL1
    Signaling pathways regulating pluripotency of stem cells BMP2,PCGF1,NODAL,FGFR2,AXIN1,NANOG,PCGF5,BMP4,MAPK13,FZD1
    Basal cell carcinoma STK36,TCF7L2,BMP2,WNT10B,FZD6,Shh,DVL2,FZD1,AXIN2,WNT4
    Proteoglycans in cancer ROCK2,RRAS,ERBB2,RDX,FAS,RHOA,RPS6KB2,TNF,AKT1,ERBB3

    Protein Function

    WNT16 has several biochemical functions, for example, frizzled binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT16 itself. We selected most functions WNT16 had, and list some proteins which have the same functions with WNT16. You can find most of the proteins on our site.

    Function Related Protein
    frizzled binding WNT1,WNT8B,SDCBP,ROR2,WNT4B,WNT9A,BAMBI,WNT5B,LRP6,RNF43

    Interacting Protein

    WNT16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT16 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT16.

    BCL6

    Resources

    Gene Families

    Research Area

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