wtap
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  • Official Full Name
  • Wilms tumor 1 associated protein
  • Background
  • The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform.
  • Synonyms
  • WTAP; Wilms tumor 1 associated protein; pre-mRNA-splicing regulator WTAP; KIAA0105; MGC3925; hFL(2)D; PNAS-132; WT1-associated protein; female-lethal(2)D homolog; wilms tumor 1-associating protein; Wilms tumour 1-associating protein; putative pre-mRNA spl
Cat.#:WTAP-447HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WTAP Protein, His-tagged
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Cat.#:WTAP-186HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WTAP protein, T7-tagged
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Cat.#:WTAP-3014HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Wilms Tumor 1 Associated Protein, T7-tagged
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Cat.#:WTAP-31529THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WTAP, T7 -tagged
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Cat.#:WTAP-321HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human WTAP protein, GST-tagged
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Cat.#:WTAP-3744HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WTAP, GST-tagged
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Cat.#:WTAP-7047HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WTAP, GST tagged
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Cat.#:WTAP-18591MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse WTAP Protein
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Cat.#:WTAP-5223RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey WTAP Protein, His-tagged
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Cat.#:WTAP-10226ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish WTAP
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Cat.#:WTAP-276HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human WTAP 293 Cell Lysate
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Cat.#:WTAP-277HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human WTAP 293 Cell Lysate
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Involved Pathway

WTAP involved in several pathways and played different roles in them. We selected most pathways WTAP participated on our site, such as Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with WTAP were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gene Expression
TSN; NR2E1; ZNF584; ZNF383; SAP30; UHRF1; POLR3H; ZNF215; ZNF596; ZNF561
Processing of Capped Intron-Containing Pre-mRNA
ZCRB1; HNRNPR; SF3B4; HNRPL; HNRNPL; HNRNPA0B; PCBP2; SNRNP25; PDCD7; CLP1

Protein Function

WTAP has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WTAP itself. We selected most functions WTAP had, and list some proteins which have the same functions with WTAP. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein TRAIP; MED1; CCPG1; ZNHIT3; MRC1; ZBTB7A; HCST; CPT1B; TCF7L1A; MTNR1A

Interacting Protein

WTAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WTAP here. Most of them are supplied by our site. Hope this information will be useful for your research of WTAP.
IKZF1; VPS52; YWHAZ; MAGEA11; TAB1; Sod1; Srsf1; METTL3

WTAP Related Articles

Venkatareddy, M; Wang, S; et al. Estimating Podocyte Number and Density Using a Single Histologic Section. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 25:1118-1129(2014).
Leader, R; Deol-Poonia, RK; et al. Immunohistochemical localization of WT1 in epithelial salivary tumors. PATHOLOGY RESEARCH AND PRACTICE 210:726-732(2014).